Sepiapterin Reductase, 1-261 Aa Recombinant Protein

Sepiapterin reductase (SPR) belongs to the short-chain dehydrogenase/reductase (SDR) family and also reduces various exogenous carbonyl compounds including phenylpropanedione. SPR is an essential enzyme for the biosynthesis of tetrahydrobiopterin, an essential cofactor for aromatic amino acid hydrolases including tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis. Defects in SPR cause DOPA-responsive dystonia defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Recombinant human SPR protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Small volumes of Sepiapterin Reductase, 1-261 aa recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS636754 is a recombinant protein targeting Sepiapterin Reductase, 1-261 aa. Also known as Sepiapterin Reductase, 1-261 aa, Recombinant, Human (SPR, sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase). Host: E Coli.