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CCL11, Aa24-97 Human, His Tag (CCL11) Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS636762

CCL11 is a small cytokine belonging to the CC chemokine family that is also known as eotaxin-1. CCL11 selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses. The effects of CCL11 are mediated by its… More details

$620 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CCL11, aa24-97 Human, His tag, Recombinant Protein
Full Product Name
CCL11, aa24-97, Recombinant Human, His tag
Product Gene Name
CCL11 recombinant protein
Sequence
MGSSHHHHHH SSGLVPRGSH MGPASVPTTC CFNLANRKIP LQRLESYRRI TSGKCPQKAV IFKTKLAKDI CADPKKKWVQ DSMKYLDQKS PTPKP
Form/Format
Supplied as a liquid in PBS, pH 7.4, 10% glycerol.
Purity/Purification
Affinity Purified
~90% (SDS-PAGE) Purified by immunoaffinity chromatography.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
10.6 kDa
Chromosome Location
Chromosome: 17; NC_000017.10 (32612687..32615199). Location: 17q12
3D Structure
ModBase 3D Structure for Q6I9T4

Product Categories/Family for CCL11 recombinant protein

Growth Factors; Cytokines; Growth Factors-CCL

Other Notes

Small volumes of CCL11 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCL11 purchase

MBS636762 is a recombinant protein targeting CCL11. Also known as CCL11, aa24-97, Recombinant Human, His tag.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL11. It may not necessarily be applicable to this product.

NCBI GI #
48146959
NCBI GeneID
6356
NCBI Accession #
CAG33702.1
UniProt Primary Accession #
Q6I9T4
UniProt Related Accession #
P51671
NCBI Official Full Name
CCL11
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 11
NCBI Official Symbol
CCL11
NCBI Official Synonym Symbols
SCYA11
UniProt Protein Name
CCL11 protein
Protein Family
Eotaxin
UniProt Gene Name
CCL11
UniProt Entry Name
Q6I9T4_HUMAN
NCBI Protein Information
eotaxin; eotaxin-1; eosinophil chemotactic protein; small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin)

NCBI Summary for CCL11

This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Jul 2013]
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UniProt Comments for CCL11

CCL11: In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; chemokine activity

Biological Process: chronic inflammatory response; mast cell chemotaxis; response to virus; actin filament organization; cytoskeleton organization and biogenesis; chemotaxis; signal transduction; protein amino acid phosphorylation; cellular calcium ion homeostasis; regulation of cell shape; positive regulation of angiogenesis; response to radiation; positive regulation of actin filament polymerization; eosinophil chemotaxis; positive regulation of endothelial cell proliferation; immune response; inflammatory response; cell adhesion; positive regulation of cell migration

Disease: Asthma, Susceptibility To; Human Immunodeficiency Virus Type 1, Susceptibility To
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Research Articles on CCL11

1. These data uncover a previously unknown role for NRF2 in regulating Eotaxin-1 expression and further the mechanistic understanding of this pathway in modulating inflammatory lung disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CCL11 recombinant protein

 Products by Pathway  Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 CXCR3-mediated Signaling Events Pathway antibodies  CXCR3-mediated Signaling Events Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram

Diseases associated with CCL11 recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >644 publications with CCL11 and Inflammation
 Respiratory Tract Diseases Antibodies  >535 publications with CCL11 and Respiratory Tract Diseases
 Hypersensitivity Antibodies  >521 publications with CCL11 and Hypersensitivity
 Asthma Antibodies  >486 publications with CCL11 and Asthma
 Lung Diseases Antibodies  >431 publications with CCL11 and Lung Diseases
 Respiratory Hypersensitivity Antibodies  >382 publications with CCL11 and Respiratory Hypersensitivity
 Necrosis Antibodies  >178 publications with CCL11 and Necrosis
 Bronchial Hyperreactivity Antibodies  >81 publications with CCL11 and Bronchial Hyperreactivity
 Drug Hypersensitivity Antibodies  >72 publications with CCL11 and Drug Hypersensitivity
 Dermatitis, Atopic Antibodies  >56 publications with CCL11 and Dermatitis, Atopic

Organs/Tissues associated with CCL11 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >459 publications with CCL11 and Lung
 Heart Antibodies  >65 publications with CCL11 and Heart
 Intestine Antibodies  >50 publications with CCL11 and Intestine
 Uterus Antibodies  >12 publications with CCL11 and Uterus
 Kidney Antibodies  >10 publications with CCL11 and Kidney
 Stomach Antibodies  >6 publications with CCL11 and Stomach
 Pancreas Antibodies  >5 publications with CCL11 and Pancreas
 Mammary Gland Antibodies  >3 publications with CCL11 and Mammary Gland
 Uncharacterized Tissue Antibodies  >1 publications with CCL11 and Uncharacterized Tissue
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