Bcl 2, Aa1-211 (BCL2) Recombinant Protein

Bcl-2: a antiapoptotic member of the Bcl-2 family. Regulates cell death by controlling the mitochondrial membrane permeability. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Phosphorylation by JNKs may increase its antiapoptotic functions.

Protein type: Oncoprotein; Autophagy; Membrane protein, integral; Apoptosis

Cellular Component: endoplasmic reticulum membrane; nuclear membrane; mitochondrion; endoplasmic reticulum; cell; integral to membrane; cytosol; pore complex; mitochondrial outer membrane; membrane; cytoplasm; mitochondrial membrane; intracellular; nucleus; myelin sheath

Molecular Function: BH domain binding; identical protein binding; protein homodimerization activity; protease binding; protein phosphatase 2A binding; channel activity; channel inhibitor activity; protein phosphatase binding; transcription factor binding; protein binding; protein heterodimerization activity; sequence-specific DNA binding; ubiquitin protein ligase binding; BH3 domain binding

Biological Process: positive regulation of catalytic activity; focal adhesion formation; developmental growth; pigment granule organization and biogenesis; regulation of cell cycle; response to toxin; ear development; negative regulation of myeloid cell apoptosis; B cell receptor signaling pathway; regulation of protein localization; negative regulation of ossification; regulation of transmembrane transporter activity; oligodendrocyte differentiation; negative regulation of neuron apoptosis; kidney development; T cell differentiation; spleen development; response to drug; positive regulation of neuron maturation; axon regeneration; cell aging; regulation of calcium ion transport; positive regulation of cell growth; response to ethanol; DNA damage response, signal transduction resulting in induction of apoptosis; response to estrogen stimulus; response to heat; regulation of gene expression; negative regulation of osteoblast proliferation; response to oxidative stress; lymphocyte homeostasis; negative regulation of apoptosis; positive regulation of pigmentation; positive regulation of smooth muscle cell migration; response to L-ascorbic acid; response to insulin stimulus; response to organic substance; negative regulation of cell proliferation; positive regulation of skeletal muscle fiber development; ureteric bud development; positive regulation of cell proliferation; transmembrane transport; regulation of viral genome replication; negative regulation of cell migration; response to nutrient; response to aluminum ion; leukocyte homeostasis; aging; mesenchymal cell development; response to inorganic substance; CD8-positive, alpha-beta T cell lineage commitment; B cell lineage commitment; positive regulation of peptidyl-serine phosphorylation; response to UV-B; cell proliferation; peptidyl-serine phosphorylation; endoplasmic reticulum calcium ion homeostasis; response to copper ion; pigmentation; ureteric bud branching; homeostasis of number of cells within a tissue; response to hypoxia; brain development; negative regulation of cell growth; response to nicotine; renal system process; protein polyubiquitination; response to glucocorticoid stimulus; T cell differentiation in the thymus; lymphoid progenitor cell differentiation; positive regulation of multicellular organism growth; glomerulus development; response to organic cyclic substance; response to caffeine; post-embryonic development; cochlear nucleus development; regulation of apoptosis; cellular response to glucose starvation; cell-cell adhesion; regulation of mitochondrial membrane potential; response to folic acid; positive regulation of B cell proliferation; negative regulation of mitotic cell cycle; T cell homeostasis; response to electrical stimulus; cell growth; defense response to virus; response to corticosterone stimulus; release of cytochrome c from mitochondria; regulation of protein homodimerization activity; actin filament organization; digestive tract morphogenesis; organ growth; organ morphogenesis; induction of apoptosis via death domain receptors; response to steroid hormone stimulus; B cell differentiation; regulation of pigmentation during development; gland morphogenesis; regulation of mitochondrial membrane permeability; regulation of nitrogen utilization; metanephros development; oocyte development; B cell proliferation; response to peptide hormone stimulus; regulation of protein heterodimerization activity; response to cAMP; behavioral fear response; melanin metabolic process; apoptosis; negative regulation of retinal cell programmed cell death; regulation of cell-matrix adhesion; pigmentation during development; cell morphogenesis; regulation of protein stability; protein amino acid dephosphorylation; apoptotic mitochondrial changes; B cell homeostasis; ovarian follicle development; regulation of catalytic activity; positive regulation of melanocyte differentiation; melanocyte differentiation; response to gamma radiation; hemopoiesis; negative regulation of cellular pH reduction; response to iron ion; ossification; hair follicle morphogenesis; thymus development; male gonad development; peptidyl-threonine phosphorylation; regulation of programmed cell death; cellular calcium ion homeostasis; immune system development; T cell lineage commitment; neuron apoptosis; axonogenesis; response to hydrogen peroxide; response to cytokine stimulus; response to DNA damage stimulus; induction of apoptosis by oxidative stress; growth