Glutathione S-Transferase Omega 1, 140d Alanine-to-Aspartate Variant Recombinant Protein

Recombinant GSTO1 140D comprises a 241 amino acid fragment (1-241) corresponding to the GSTO1 140D mutant mature protein, which is expressed in E. coli with an amino-terminal hexahistidine tag.

GSTO1 is a member of the theta class glutathione S- transferase-like (GSTTL) protein family. GSTO1 is expressed in a wide range of human tissues and exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities and also catalyzes the reduction of monomethylarsonate, an intermediate in the pathway of arsenic biotransformation. GSTO1 protects from oxidative stress, a risk factor for Alzheimer disease, vascular dementia and stroke. Several polymorphisms in the coding regions of the human GSTO1 have been identified. A polymorphism causing an alanine-to-aspartate (A140D) substitution in amino acid 140 produces a variant with lowered enzyme activities in the arsenic biotransformation.

Small volumes of Glutathione S-transferase omega 1, 140D alanine-to-aspartate variant recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS636822 is a recombinant protein targeting Glutathione S-transferase omega 1, 140D alanine-to-aspartate variant. Also known as Glutathione S-transferase omega 1, 140D alanine-to-aspartate variant, Recombinant, Human (GSTTL p28, Glutathione transferase omega, Gutathione-S-transferase like, Monomethyl Arsenous Reductase). Host: Human, Recombinant, E Coli.