Matrix Metalloproteinase 8 (MMP8) Active Protein

Name: MMP8 Active Protein; Matrix Metalloproteinase 8; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS636832
Price: 1045 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS636832

Full-length recombinant human neutrophil pro-collagenase (MMP-8), latent form. Recombinant Human MMP-8 produced in E.Coli is a single, non-glycosylated, polypeptide chain having a molecular mass of 75kD. Recombinant MMP-8 is purified by proprietary… More details

$1045 / 1 Unit +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Matrix Metalloproteinase 8 (MMP8), Active Protein

Full Product Name

Matrix Metalloproteinase 8, Human, Recombinant (MMP-8, Neutrophil ProCollagenase, Collagenase2)

Product Gene Name

MMP8 active protein

Host

E Coli

Form/Format

Supplied as a liquid in 0.05M Tris-HCl, pH 7.5, 0.2M NaCl, 5mM CaCl2, 20uM ZnSO4 and 0.1% BSA.

Purity/Purification

Highly Purified
> 90% (SDS-PAGE)

Preparation and Storage

-20 degree C
Stability: Recombinant MMP-8 although stable at 140C for 1 week, should be stored desiccated below -180C. Please avoid freeze-thaw cycles.

Molecular Weight

75kD

Chromosome Location

Chromosome: 11; NC_000011.9 (102582526..102595734, complement). Location: 11q22.3

OMIM

120355

3D Structure

ModBase 3D Structure for P22894

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Recombinant MMP-8 biological activity was found to be 100 units/ml after activation with APMA by solution assay method (10U0 assays).

Unit Definition

One unit of collagenolytic activity is defined as the cleavage of 1µg of collagen per minute.

Product Categories/Family for MMP8 active protein

Molecular Biology; MB-Matrix Metalloproteinases

Application Notes for MMP8 active protein

Used as a standard for analyzing mammalian collagenase activity.

Other Notes

Small volumes of MMP8 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MMP8 purchase

MBS636832 is an active protein targeting MMP8. Also known as Matrix Metalloproteinase 8, Human, Recombinant (MMP-8, Neutrophil ProCollagenase, Collagenase2). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for MMP8. It may not necessarily be applicable to this product.

NCBI GI #

71648770

NCBI GeneID

4317

NCBI Accession #

AAZ38714.1

UniProt Primary Accession #

P22894

UniProt Secondary Accession #

Q45F99

UniProt Related Accession #

P22894

NCBI Official Full Name

matrix metalloproteinase 8 (neutrophil collagenase)

NCBI Official Synonym Full Names

matrix metallopeptidase 8 (neutrophil collagenase)

NCBI Official Symbol

MMP8

NCBI Official Synonym Symbols

HNC; CLG1; MMP-8; PMNL-CL

UniProt Protein Name

Neutrophil collagenase

UniProt Synonym Protein Names

Matrix metalloproteinase-8; MMP-8; PMNL collagenase

Protein Family

Neutrophil collagenase

UniProt Gene Name

MMP8

UniProt Synonym Gene Names

CLG1; MMP-8; PMNL-CL

UniProt Entry Name

MMP8_HUMAN

NCBI Protein Information

neutrophil collagenase; PMNL collagenase; matrix metalloproteinase-8; matrix metalloproteinase 8 (neutrophil collagenase)

NCBI Summary for MMP8

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]

UniProt Comments for MMP8

MMP8: Can degrade fibrillar type I, II, and III collagens. Belongs to the peptidase M10A family.

Protein type: Secreted; Secreted, signal peptide; Protease; EC 3.4.24.34

Chromosomal Location of Human Ortholog: 11q22.3

Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region

Molecular Function: zinc ion binding; serine-type endopeptidase activity; metalloendopeptidase activity; calcium ion binding

Biological Process: extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; proteolysis

Research Articles on MMP8

1. Evaluated gingival inflammation and the enzyme activity of MMP-8 in gingival crevicular fluid of pregnant women. The aMMP-8 values of pregnant subjects were higher compared with non-pregnant, but the difference was not statistically significant.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MMP8 active protein

Reference Product	PubMed Publications
TIMP1 active protein	>14 publications with MMP8 and TIMP1
TIMP2 active protein	>5 publications with MMP8 and TIMP2
CCL2 active protein	>2 publications with MMP8 and CCL2
EFNB1 active protein	>1 publications with MMP8 and EFNB1
PTGS2 active protein	>1 publications with MMP8 and PTGS2

Pathways associated with MMP8 active protein

Products by Pathway	Pathway Diagram
Activation Of Matrix Metalloproteinases Pathway antibodies	Activation Of Matrix Metalloproteinases Pathway Diagram
Degradation Of Collagen Pathway antibodies	Degradation Of Collagen Pathway Diagram
Degradation Of The Extracellular Matrix Pathway antibodies	Degradation Of The Extracellular Matrix Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
Matrix Metalloproteinases Pathway antibodies	Matrix Metalloproteinases Pathway Diagram

Diseases associated with MMP8 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>55 publications with MMP8 and Inflammation
Cardiovascular Diseases Antibodies	>28 publications with MMP8 and Cardiovascular Diseases
Fibrosis Antibodies	>22 publications with MMP8 and Fibrosis
Disease Models, Animal Antibodies	>20 publications with MMP8 and Disease Models, Animal
Lung Diseases Antibodies	>14 publications with MMP8 and Lung Diseases
Heart Diseases Antibodies	>11 publications with MMP8 and Heart Diseases
Liver Diseases Antibodies	>10 publications with MMP8 and Liver Diseases
Atherosclerosis Antibodies	>10 publications with MMP8 and Atherosclerosis
Necrosis Antibodies	>9 publications with MMP8 and Necrosis
Liver Cirrhosis Antibodies	>8 publications with MMP8 and Liver Cirrhosis

Organs/Tissues associated with MMP8 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>61 publications with MMP8 and Blood
Connective Tissue Antibodies	>13 publications with MMP8 and Connective Tissue
Skin Antibodies	>13 publications with MMP8 and Skin
Liver Antibodies	>10 publications with MMP8 and Liver
Bone Marrow Antibodies	>8 publications with MMP8 and Bone Marrow