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Fibroblast Growth Factor 20 (FGF20) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS636884

The FGF family plays important roles in morphogenesis, cellular differentiation, angiogenesis, tissue remodeling, in ammation and oncogenesis. Fibroblast Growth Factor-20 (FGF-20) is a newly discovered neurotrophic factor belonging to the FGF family. FGF-20… More details

$370 / 0.003 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Fibroblast Growth Factor 20 (FGF20), Active Protein
Full Product Name
Fibroblast Growth Factor 20, Human (FGF20) Recombinant
Product Gene Name
FGF20 active protein
Form/Format
Supplied as a lyophilized powder in 20mM Tris, pH 7.6, 1.5M sodium chloride. Reconstitute in sterile dH2O to a concentration of 0.1-1mg/ml. This solution can then be diluted into other aqueous buffers.
Purity/Purification
Highly Purified
90% by SDS-PAGE and HPLC analyses. Endotoxin: 0.1ng/ug (1EU/ug)
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
23.2kD
Chromosome Location
Chromosome: 8; NC_000008.10 (16850334..16859674, complement). Location: 8p22
OMIM
605558
3D Structure
ModBase 3D Structure for Q9NP95
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors is 10ng/ml, corresponding to a speci c activity of 1 x 10e5 units/mg.
Country of Origin
USA
Reconstitution
Reconstitute in sterile dH2O to a concentration of 0.1-1mg/ml. This solution can then be diluted into other aqueous buffers.

Product Categories/Family for FGF20 active protein

Growth Factors; Cytokines; Growth Factors-FGF

Other Notes

Small volumes of FGF20 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FGF20 purchase

MBS636884 is an active protein targeting FGF20. Also known as Fibroblast Growth Factor 20, Human (FGF20) Recombinant.

Additional Details

NCBI/Uniprot data below describe general gene information for FGF20. It may not necessarily be applicable to this product.

NCBI GI #
9789947
NCBI GeneID
26281
NCBI Accession #
NP_062825.1
UniProt Primary Accession #
Q9NP95
UniProt Secondary Accession #
B2RPH5
UniProt Related Accession #
Q9NP95
GenBank Nucleotide #
NM_019851.2
NCBI Official Full Name
fibroblast growth factor 20
NCBI Official Synonym Full Names
fibroblast growth factor 20
NCBI Official Symbol
FGF20
NCBI Official Synonym Symbols
FGF-20
UniProt Protein Name
Fibroblast growth factor 20
Protein Family
Fibroblast growth factor
UniProt Gene Name
FGF20
UniProt Synonym Gene Names
FGF-20
UniProt Entry Name
FGF20_HUMAN
NCBI Protein Information
fibroblast growth factor 20

NCBI Summary for FGF20

The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility. [provided by RefSeq, Oct 2009]
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UniProt Comments for FGF20

FGF20: Neurotrophic factor that regulates central nervous development and function. Belongs to the heparin-binding growth factors family.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: extracellular region

Molecular Function: growth factor activity; fibroblast growth factor receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; inner ear receptor cell differentiation; cell-cell signaling; nerve growth factor receptor signaling pathway; positive regulation of cell proliferation; insulin receptor signaling pathway; innate immune response; regulation of cardiac muscle cell proliferation; signal transduction

Disease: Renal Hypodysplasia/aplasia 2
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Research Articles on FGF20

1. The results have not shown any effect of rs12720208 in the FGF20 gene on the risk of Parkinson's disease in patients residing in Russia

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FGF20 active protein

 Reference Product  PubMed Publications
 FGFR1 active protein  >13 publications with FGF20 and FGFR1
 FGF18 active protein  >8 publications with FGF20 and FGF18
 FGF10 active protein  >7 publications with FGF20 and FGF10
 FGF7 active protein  >6 publications with FGF20 and FGF7
 FGF4 active protein  >5 publications with FGF20 and FGF4
 FGF6 active protein  >3 publications with FGF20 and FGF6
 FGF23 active protein  >3 publications with FGF20 and FGF23
 FGF19 active protein  >2 publications with FGF20 and FGF19
 FGFR4 active protein  >2 publications with FGF20 and FGFR4

Pathways associated with FGF20 active protein

 Products by Pathway  Pathway Diagram
 Activated Point Mutants Of FGFR2 Pathway antibodies  Activated Point Mutants Of FGFR2 Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 FGFR Ligand Binding And Activation Pathway antibodies  FGFR Ligand Binding And Activation Pathway Diagram

Diseases associated with FGF20 active protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >18 publications with FGF20 and Nervous System Diseases
 Brain Diseases Antibodies  >18 publications with FGF20 and Brain Diseases
 Mouth Diseases Antibodies  >8 publications with FGF20 and Mouth Diseases
 Carcinoma Antibodies  >5 publications with FGF20 and Carcinoma
 Necrosis Antibodies  >2 publications with FGF20 and Necrosis
 Intestinal Diseases Antibodies  >2 publications with FGF20 and Intestinal Diseases
 Cognition Disorders Antibodies  >1 publications with FGF20 and Cognition Disorders
 Edema Antibodies  >1 publications with FGF20 and Edema
 Tremor Antibodies  >1 publications with FGF20 and Tremor
 Multiple Myeloma Antibodies  >1 publications with FGF20 and Multiple Myeloma

Organs/Tissues associated with FGF20 active protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >20 publications with FGF20 and Brain
 Intestine Antibodies  >6 publications with FGF20 and Intestine
 Lung Antibodies  >3 publications with FGF20 and Lung
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