G6b, Fc Chimera Active Protein

G6b is a t ype I transmembrane glycoprotein in the immunoglobul in superfamily that is encoded within the human class III major histocompatibility complex (1 ­ 3). It is expressed mainly on platelets, and has also been detected on megakaryocytes and the human cell line K562 (2 ­ 5). Crosslinking of G6b inhibits agonist­stimulated platelet aggregation and activation (5). The 241 amino acid (aa) human G6b isotype B (G6b­B) contains a 17 aa signal sequence, a 125 aa extracellular domain with one V­type Ig ­like domain and one N­linked glycosylation site, a 21 aa transmembrane sequence and a 78 aa cytoplasmic sequence with two ITIM inhibitory motifs and a SH3 bindingsite (1, 2). Phosphorylation at Y211 within the first ITIM is required for interaction with SHP adapt or/ tyrosine phosphatase proteins (2, 3). Of several described isoforms, all are identical within aa 22­136, which includes most of the extracellular domain. One contains an alternate signal sequence, while at least two lack a transmembrane sequence and are secreted (2). At least two others, including G6b­A, express alternate C­t ermini that lack the ITIM motifs. Of the known isoforms, G6b­A and G6b­B predominate in platelets. It is possible that G6b­A may be paired with and control inhibition by G6b­B (4). Heparin interacts with the G6b extracellular domain with high­affinity and may contribute to G6b activity or adhesion to extracellular matrix (6).

Small volumes of G6b, Fc Chimera active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS636950 is an active protein targeting G6b, Fc Chimera. Also known as G6b, Recombinant, Human, Fc Chimera (C6orf25, chromosome 6 open reading frame 25MGC142279, MGC142281, NG31, Protein G6b).