Mst1 (STK4) Active Protein

Name: STK4 Active Protein; Mst1; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS637106
Price: 1055 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS637106

Macrophage stimulating protein (MSP), also known as HGF-like protein, and scatter factor-2, is a member of the HGF family of growth factors. MSP is secreted as an inactive single chain precursor (pro-MSP) that contains a PAN/APPLE-like domain, four kringle… More details

$1055 / 0.025 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Mst1 (STK4), Active Protein

Full Product Name

Mst1, Recombinant, Mouse (Hepatocyte Growth Factor-like Protein, Macrophage Stimulatory Protein, MSP, Hgfl)

Product Gene Name

STK4 active protein

Host

CHO cells

Form/Format

Supplied as a lyophilized powder from PBS, BSA. Reconstitute with PBS, 0.1% human or BSA to 0.1mg/ml.

Purity/Purification

Highly Purified
~95% (SDS-PAGE)

Preparation and Storage

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS, 0.1% HSA or BSA. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

~53.7kD & 25kD

Chromosome Location

Chromosome: 20; NC_000020.10 (43595120..43708600). Location: 20q11.2-q13.2

OMIM

604965

3D Structure

ModBase 3D Structure for Q13043

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Measured by its binding ability in a functional ELISA. When Recombinant Mouse MSP R/Ron Fc Chimera is coated at 1ug/ml (100ul/well), the concentration of Recombinant Mouse MSP/MST1 that produces 50% of the optimal binding response is found to be ~1-6ng/ml.

Endotoxin Level

~1EU/1ug (LAL)

Product Categories/Family for STK4 active protein

Growth Factors; Cytokines; Growth Factors-HGF

Other Notes

Small volumes of STK4 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for STK4 purchase

MBS637106 is an active protein targeting STK4. Also known as Mst1, Recombinant, Mouse (Hepatocyte Growth Factor-like Protein, Macrophage Stimulatory Protein, MSP, Hgfl). Host: CHO cells.

Additional Details

NCBI/Uniprot data below describe general gene information for STK4. It may not necessarily be applicable to this product.

NCBI GI #

1117791

NCBI GeneID

6789

NCBI Accession #

AAA83254.1

UniProt Primary Accession #

Q13043

UniProt Secondary Accession #

Q15802; Q4G156; Q5H982; Q6PD60; Q9BR32; Q9NTZ4; B2RCR8

UniProt Related Accession #

Q13043

NCBI Official Full Name

MST1

NCBI Official Synonym Full Names

serine/threonine kinase 4

NCBI Official Symbol

STK4

NCBI Official Synonym Symbols

KRS2; MST1; YSK3; TIIAC

UniProt Protein Name

Serine/threonine-protein kinase 4

UniProt Synonym Protein Names

Mammalian STE20-like protein kinase 1; MST-1; STE20-like kinase MST1; Serine/threonine-protein kinase Krs-2

Protein Family

Serine/threonine-protein kinase

UniProt Gene Name

STK4

UniProt Synonym Gene Names

KRS2; MST1; MST-1; MST1/N; MST1/C

UniProt Entry Name

STK4_HUMAN

NCBI Protein Information

serine/threonine-protein kinase 4; MST-1; STE20-like kinase MST1; mammalian sterile 20-like 1; kinase responsive to stress 2; mammalian STE20-like protein kinase 1; serine/threonine-protein kinase Krs-2; dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2))

NCBI Summary for STK4

The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]

UniProt Comments for STK4

MST1: a protein kinase of the STE20 family. Proteolytically activated by caspase during apoptosis. Activated by apoptotic signals as well as other stress conditions. Full activation requires both phosphorylation and caspase-mediated cleavage. Phosphorylation at serine 327 of Mst1, which is close to the caspase-3 recognition site, inhibits caspase-mediated cleavage.

Protein type: Protein kinase, STE; Autophagy; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; STE group; STE20 family; MST subfamily

Chromosomal Location of Human Ortholog: 20q11.2-q13.2

Cellular Component: nucleoplasm; cytoplasm; cytosol; nucleus

Molecular Function: protein dimerization activity; identical protein binding; protein serine/threonine kinase activity; protein serine/threonine kinase activator activity; protein binding; protein homodimerization activity; magnesium ion binding; transcription factor binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: central nervous system development; positive regulation of protein binding; positive regulation of apoptosis; apoptosis; protein amino acid autophosphorylation; cell morphogenesis; negative regulation of organ growth; signal transduction; protein amino acid phosphorylation; patterning of blood vessels; keratinocyte differentiation; negative regulation of cell proliferation; peptidyl-serine phosphorylation; positive regulation of fat cell differentiation; neural tube formation

Disease: T-cell Immunodeficiency, Recurrent Infections, And Autoimmunity With Or Without Cardiac Malformations

Research Articles on STK4

1. Results indicated that Mst1 might be a promising anticancer target.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with STK4 active protein

Reference Product	PubMed Publications
MST1 active protein	>82 publications with STK4 and MST1
RASSF1 active protein	>15 publications with STK4 and RASSF1
CASP3 active protein	>13 publications with STK4 and CASP3
LATS1 active protein	>10 publications with STK4 and LATS1
SAV1 active protein	>9 publications with STK4 and SAV1
RASSF5 active protein	>8 publications with STK4 and RASSF5
LATS2 active protein	>6 publications with STK4 and LATS2
FOXO3 active protein	>4 publications with STK4 and FOXO3
RASSF2 active protein	>2 publications with STK4 and RASSF2
PRKRIR active protein	>1 publications with STK4 and PRKRIR

Pathways associated with STK4 active protein

Products by Pathway	Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
Non-small Cell Lung Cancer Pathway antibodies	Non-small Cell Lung Cancer Pathway Diagram
Non-small Cell Lung Cancer Pathway antibodies	Non-small Cell Lung Cancer Pathway Diagram
Pathways In Cancer antibodies	Pathways In Cancer Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By Hippo Pathway antibodies	Signaling By Hippo Pathway Diagram

Diseases associated with STK4 active protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>32 publications with STK4 and Neoplasms
Neoplasms, Experimental Antibodies	>6 publications with STK4 and Neoplasms, Experimental
Genital Diseases, Male Antibodies	>5 publications with STK4 and Genital Diseases, Male
Liver Diseases Antibodies	>5 publications with STK4 and Liver Diseases
Liver Neoplasms Antibodies	>5 publications with STK4 and Liver Neoplasms
Carcinoma, Hepatocellular Antibodies	>5 publications with STK4 and Carcinoma, Hepatocellular
Liver Neoplasms, Experimental Antibodies	>3 publications with STK4 and Liver Neoplasms, Experimental
Lung Neoplasms Antibodies	>3 publications with STK4 and Lung Neoplasms
Adenocarcinoma Antibodies	>3 publications with STK4 and Adenocarcinoma
Hypertrophy Antibodies	>3 publications with STK4 and Hypertrophy

Organs/Tissues associated with STK4 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>12 publications with STK4 and Blood
Muscle Antibodies	>10 publications with STK4 and Muscle
Lung Antibodies	>7 publications with STK4 and Lung
Liver Antibodies	>6 publications with STK4 and Liver
Prostate Antibodies	>6 publications with STK4 and Prostate
Bone Antibodies	>4 publications with STK4 and Bone
Vascular Antibodies	>3 publications with STK4 and Vascular
Intestine Antibodies	>2 publications with STK4 and Intestine
Thyroid Antibodies	>2 publications with STK4 and Thyroid
Pancreas Antibodies	>2 publications with STK4 and Pancreas