SERPINF1 Active Protein – Cat# MBS637168

PEDF (SERPINF1) Active Protein

Name: SERPINF1 Active Protein; PEDF; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS637168
Price: 465 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS637168

Recombinant Human PEDF (Pigment epithelium-derived factor, SerpinF1, EPC-1) is a noninhibitory serpin with neurotrophic, anti- angiogenic, and anti-tumorigenic properties. It is a 50kD glycoprotein produced and secreted in many tissues throughout the body. A… More details

$465 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PEDF (SERPINF1), Active Protein

Full Product Name

PEDF, Recombinant, Human (Pigment Epithelial Derived Factor, SerpinF1, EPC-1)

Product Gene Name

SERPINF1 active protein

Sequence

MQNPASPPEE GSPDPDSTGA LVEEEDPFFK VPVNKLAAAV
SNFGYD LYRV RSSMSPTTNV LLSPLSVATA LSALSLGAEQ RTESIIHRAL YYDLISSPDI HGTYKELLDT VTAPQKNLKS ASRIVFEKKL RIKSSFVAPL EKSYGTRPRV LTGNPRLDLQ EINNWVQAQM KGKLARSTKE IPDEISILLL GVAHFKGQWV TKFDSRKTSL EDFYLDEERT VRVPMMSDPK AVLRYGLDSD LSCKIAQLPL TGSMSIIFFL PLKVTQNLTL IEESLTSEFI HDIDRELKTV QAVLTVPKLK LSYEGEVTKS LQEMKLQSLF DSPDFSKITG KPIKLTQVEH RAGFEWNEDG AGTTPSPGLQ
PAHLTF PLDY HLNQPFIFVL RDTDTGALLF IGKILDPRGP

Form/Format

Supplied as a lyophilized powder.

Purity/Purification

Highly Purified
90% by SDS-PAGE, HPLC

Preparation and Storage

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

44.5kD

Chromosome Location

Chromosome: 17; NC_000017.10 (1665259..1680859). Location: 17p13.3

OMIM

172860

3D Structure

ModBase 3D Structure for P36955

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Data Not Available

Endotoxin Level

0.1ng/ug (1EU/ug).

Product Categories/Family for SERPINF1 active protein

Molecular Biology; MB-Protease Inhibitors

Other Notes

Small volumes of SERPINF1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SERPINF1 purchase

MBS637168 is an active protein targeting SERPINF1. Also known as PEDF, Recombinant, Human (Pigment Epithelial Derived Factor, SerpinF1, EPC-1).

Additional Details

NCBI/Uniprot data below describe general gene information for SERPINF1. It may not necessarily be applicable to this product.

NCBI GI #

39725934

NCBI GeneID

5176

NCBI Accession #

NP_002606.3

UniProt Primary Accession #

P36955

UniProt Secondary Accession #

Q13236; Q2TU83; Q96CT1; Q96R01; Q9BWA4; F1T092

UniProt Related Accession #

P36955

GenBank Nucleotide #

NM_002615.5

NCBI Official Full Name

pigment epithelium-derived factor

NCBI Official Synonym Full Names

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1

NCBI Official Symbol

SERPINF1

NCBI Official Synonym Symbols

OI6; OI12; PEDF; EPC-1; PIG35

UniProt Protein Name

Pigment epithelium-derived factor

UniProt Synonym Protein Names

Cell proliferation-inducing gene 35 protein; EPC-1; Serpin F1

Protein Family

Pigment epithelium-derived factor

UniProt Gene Name

SERPINF1

UniProt Synonym Gene Names

PEDF; PEDF

UniProt Entry Name

PEDF_HUMAN

NCBI Protein Information

pigment epithelium-derived factor; serpin F1; cell proliferation-inducing gene 35 protein; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1

NCBI Summary for SERPINF1

The protein encoded by this gene is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells.[provided by RefSeq, Mar 2011]

UniProt Comments for SERPINF1

PEDF: a secreted neurotrophic protein that induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. The N-terminal (AA 44-121) exhibits neurite outgrowth-inducing activity. The C-terminal exposed loop (AA 382-418) is essential for serpin activity. Extracellular phosphorylation enhances antiangiogenic activity.

Protein type: Secreted, signal peptide; Inhibitor; Secreted

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: axon hillock; extracellular matrix; extracellular space; perinuclear region of cytoplasm; extracellular region; melanosome; basement membrane

Molecular Function: serine-type endopeptidase inhibitor activity

Biological Process: cell proliferation; positive regulation of neurogenesis; negative regulation of angiogenesis; ovulation cycle; short-term memory; retina development in camera-type eye; response to arsenic; negative regulation of inflammatory response; multicellular organismal development; response to acidity; kidney development; aging

Disease: Osteogenesis Imperfecta, Type Vi

Research Articles on SERPINF1

1. Expressional change of PEDF and TNF-alpha is in relation to angiogenesis of bladder tumor

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SERPINF1 active protein

Reference Product	PubMed Publications
A2M active protein	>1 publications with SERPINF1 and A2M
VEGFA active protein	>1 publications with SERPINF1 and VEGFA

Diseases associated with SERPINF1 active protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>2 publications with SERPINF1 and Nervous System Diseases
Cell Transformation, Neoplastic Antibodies	>1 publications with SERPINF1 and Cell Transformation, Neoplastic
Proteinuria Antibodies	>1 publications with SERPINF1 and Proteinuria
Lung Neoplasms Antibodies	>1 publications with SERPINF1 and Lung Neoplasms
Weight Loss Antibodies	>1 publications with SERPINF1 and Weight Loss

Organs/Tissues associated with SERPINF1 active protein

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>15 publications with SERPINF1 and Nerve
Bone Antibodies	>14 publications with SERPINF1 and Bone
Eye Antibodies	>13 publications with SERPINF1 and Eye
Connective Tissue Antibodies	>6 publications with SERPINF1 and Connective Tissue
Adipose Tissue Antibodies	>5 publications with SERPINF1 and Adipose Tissue
Blood Antibodies	>5 publications with SERPINF1 and Blood
Brain Antibodies	>4 publications with SERPINF1 and Brain
Skin Antibodies	>3 publications with SERPINF1 and Skin
Embryonic Tissue Antibodies	>2 publications with SERPINF1 and Embryonic Tissue
Lung Antibodies	>2 publications with SERPINF1 and Lung