Thioredoxin Reductase 2, Selcys523cys (TXNRD3) Recombinant Protein

The mammalian thioredoxin reductases (TrxRs) are a family of selenocysteine-containing pyridine nucleotide-disulfide oxido-reductases. All the mammalian TrxRs are homologous to glutathione reductase with respect to primary structure including the conserved redox catalytic site (-Cys-Val-Asn-Val-Gly-Cys-) but distinctively with a C-terminal extension containing a catalytically active penultimate selenocysteine (SeCys) residue in the conserved sequence(-Gly-Cys-SeCys-Gly). TrxR is homodimeric protein in which each monomer includes an FAD prosthetic group, a NADPH binding site and a redox catalytic site. Electrons are transferred from NADPH via FAD and the active-site disulfide to C-terminal SeCys-containing redox center, which then reduces the substrate like thioredoxin. The members of TrxR family are 55 - 58kD in molecular size and composed of three isoforms including cytosolic TrxR1, mitochondrial TrxR2, and TrxR3, known as Trx and GSSG reductase (TGR). TrxR plays a key role in protection of cells against oxidative stress and redox-regulatory mechanism of transcription factors and varioMyBioSource phenomena.

Recombinant protein corresponding to aa37-524 from human Thioredoxin reductase 2 with N-His tag, expressed in E.coli. (Q99757)

Small volumes of TXNRD3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS637265 is a recombinant protein targeting TXNRD3. Also known as Thioredoxin Reductase 2, SelCys523Cys, Recombinant, Human (Thioredoxin Reductase 2, Mitochondrial, Selenoprotein Z, SelZ, TR-beta, Thioredoxin Reductase TR3, TXNRD2, KIAA1652, TRXR2). Host: E Coli.