Matrix Metalloproteinase 7, Pro (MMP7) Active Protein

Name: MMP7 Active Protein; MyBioSource
Brand: MyBioSource
SKU: MBS637274
Price: 1105 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS637274

MBS637274 is an active protein targeting Mmp7. Also known as Matrix Metalloproteinase 7, Pro, Recombinant (ProMMP-7, Promatrilysin). Host: Human recombinant from E Coli. More details

$1105 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Matrix Metalloproteinase 7, Pro (Mmp7), Active Protein

Full Product Name

Matrix Metalloproteinase 7, Pro, Recombinant (ProMMP-7, Promatrilysin)

Product Gene Name

Mmp7 active protein

Host

Human recombinant from E Coli

Form/Format

Solution in 25mM Tris-HCl (pH 7.5), 5mM CaCl2, 0.15 M sodium chloride, 0.01% Brij35 0.02%

Purity/Purification

Purified
~70% when analyzed by SDS-PAGE followed by staining with CBB R-250.

Preparation and Storage

For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 12 months.

Molecular Weight

28.924kD

Chromosome Location

Chromosome: 8; NC_005107.3 (5895393..5903105). Location: 8q11

3D Structure

ModBase 3D Structure for P50280

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Specific Activity

~3100 U/mg Unit definition: One unit of enzyme activity is defined as the digestion of 1ug of Azocoll/min. at pH 7.5 and 37ºC in the presence of 0.5mM p-aminophenylmercuric acetate.

Product Categories/Family for Mmp7 active protein

Molecular Biology; MB-Matrix Metalloproteinases

Other Notes

Small volumes of Mmp7 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Mmp7. It may not necessarily be applicable to this product.

NCBI GI #

6981214

NCBI GeneID

25335

NCBI Accession #

NP_036996.1

UniProt Primary Accession #

P50280

UniProt Related Accession #

P50280

GenBank Nucleotide #

NM_012864.2

NCBI Official Full Name

matrilysin

NCBI Official Synonym Full Names

matrix metallopeptidase 7

NCBI Official Symbol

Mmp7

NCBI Official Synonym Symbols

MPMM

UniProt Protein Name

Matrilysin

UniProt Synonym Protein Names

Matrin; Matrix metalloproteinase-7; MMP-7; Pump-1 protease; Uterine metalloproteinase

Protein Family

Matrilysin

UniProt Gene Name

Mmp7

UniProt Synonym Gene Names

Mmp-7; MMP-7

UniProt Entry Name

MMP7_RAT

NCBI Protein Information

matrilysin; MMP-7; matrin; pump-1 protease; uterine metalloproteinase; matrix metalloproteinase-7; Matrix metalloproteinase 7 (matrilysin)

NCBI Summary for Mmp7

enzyme that cleaves the alpha 2(I) chain of rat gelatin [RGD, Feb 2006]

UniProt Comments for Mmp7

Function: Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase

By similarity.

Catalytic activity: Cleavage of 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha-2(I) > alpha-1(I).

Cofactor: Binds 2 calcium ions per subunit

By similarity.Binds 2 zinc ions per subunit

By similarity.

Subcellular location: Secreted › extracellular space › extracellular matrix

Probable.

Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Sequence similarities: Belongs to the peptidase M10A family.

Research Articles on Mmp7

1. Increased extracellular nerve growth factor precursor levels following seizures are stabilized by altered MMP-7 enzymatic activity, leading to increased neuronal death via activation of p75(NTR).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Mmp7 active protein

Reference Product	PubMed Publications
Mmp10 active protein	>13 publications with Mmp7 and Mmp10
Mmp11 active protein	>8 publications with Mmp7 and Mmp11
Src active protein	>3 publications with Mmp7 and Src
Col18a1 active protein	>3 publications with Mmp7 and Col18a1
Mmp1a active protein	>2 publications with Mmp7 and Mmp1a

Pathways associated with Mmp7 active protein

Products by Pathway	Pathway Diagram
Activation Of Matrix Metalloproteinases Pathway antibodies	Activation Of Matrix Metalloproteinases Pathway Diagram
Alpha6-Beta4 Integrin Signaling Pathway antibodies	Alpha6-Beta4 Integrin Signaling Pathway Diagram
Degradation Of Collagen Pathway antibodies	Degradation Of Collagen Pathway Diagram
Degradation Of The Extracellular Matrix Pathway antibodies	Degradation Of The Extracellular Matrix Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
Matrix Metalloproteinases Pathway antibodies	Matrix Metalloproteinases Pathway Diagram
Wnt Signaling Pathway And Pluripotency antibodies	Wnt Signaling Pathway And Pluripotency Diagram
Wnt Signaling Pathway antibodies	Wnt Signaling Pathway Diagram
Wnt Signaling Pathway antibodies	Wnt Signaling Pathway Diagram

Diseases associated with Mmp7 active protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>238 publications with Mmp7 and Neoplasms
Adenocarcinoma Antibodies	>68 publications with Mmp7 and Adenocarcinoma
Neoplasm Metastasis Antibodies	>59 publications with Mmp7 and Neoplasm Metastasis
Lung Diseases Antibodies	>46 publications with Mmp7 and Lung Diseases
Inflammation Antibodies	>45 publications with Mmp7 and Inflammation
Lung Neoplasms Antibodies	>30 publications with Mmp7 and Lung Neoplasms
Fibrosis Antibodies	>28 publications with Mmp7 and Fibrosis
Colonic Neoplasms Antibodies	>26 publications with Mmp7 and Colonic Neoplasms
Breast Neoplasms Antibodies	>24 publications with Mmp7 and Breast Neoplasms
Disease Models, Animal Antibodies	>22 publications with Mmp7 and Disease Models, Animal

Organs/Tissues associated with Mmp7 active protein

Organ/Tissue Name	Pubmed Publications
Prostate Antibodies	>11 publications with Mmp7 and Prostate
Small Intestine Antibodies	>8 publications with Mmp7 and Small Intestine