Growth Hormone Releasing Factor (GHRH) Active Protein

Name: GHRH Active Protein; MyBioSource
Brand: MyBioSource
SKU: MBS637283
Price: 755 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS637283

Synthetic Human GHRH is a single, non-glycosylated, polypeptide chain containing 29 amino acids and having a molecular mass of 3359 Dalton. Corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone consisting… More details

$755 / 1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Growth Hormone Releasing Factor (GHRH), Active Protein

Full Product Name

Growth Hormone Releasing Factor, Recombinant, Human (GHRF, GHRH)

Product Gene Name

GHRH active protein

Host

E Coli

Form/Format

Supplied as a lyophilized powder from sodium phosphate monobasic, sodium phosphate dibasic. Reconstitute with sterile ddH2O to a concentration >=0.1mg/ml. GHRH can also be diluted in 1% acetic acid at a concentration of 1mg/ml.

Purity/Purification

>98%

Preparation and Storage

Lyophilized powder may be stored at -20°C. Stable for 6 months after receipt at -20°C. Reconstitute with sterile ddH2O or 1% acetic acid. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Chromosome Location

Chromosome: 20; NC_000020.10 (35879489..35887534, complement). Location: 20q11.2

OMIM

139190

3D Structure

ModBase 3D Structure for P01286

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

HuGHRH is fully biologically active, increases plasma growth hormone concentrations by directly stimulating the anterior pituitary gland to release natural human growth hormone.

Amino Acid Sequence

The free base of sermorelin has the empirical formulaC₁₄₉H₂₄₆N₄₄O₄₂S. Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg

Product Categories/Family for GHRH active protein

Molecular Biology; MB-Hormones; Steroids

Other Notes

Small volumes of GHRH active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GHRH purchase

MBS637283 is an active protein targeting GHRH. Also known as Growth Hormone Releasing Factor, Recombinant, Human (GHRF, GHRH). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for GHRH. It may not necessarily be applicable to this product.

NCBI GI #

337133

NCBI GeneID

2691

NCBI Accession #

AAA52609.1

UniProt Primary Accession #

P01286

UniProt Secondary Accession #

Q4KN10; Q5JYR1

UniProt Related Accession #

P01286

NCBI Official Full Name

growth hormone releasing factor, partial

NCBI Official Synonym Full Names

growth hormone releasing hormone

NCBI Official Symbol

GHRH

NCBI Official Synonym Symbols

GRF; INN; GHRF

UniProt Protein Name

Somatoliberin

UniProt Synonym Protein Names

Growth hormone-releasing factor; GRF; Growth hormone-releasing hormone; GHRH; Somatocrinin; Somatorelin

Protein Family

Somatoliberin

UniProt Gene Name

GHRH

UniProt Synonym Gene Names

GHRF; GRF; GHRH

UniProt Entry Name

SLIB_HUMAN

NCBI Protein Information

somatoliberin; sermorelin; somatorelin; somatocrinin; growth hormone-releasing factor; growth hormone-releasing hormone

NCBI Summary for GHRH

The protein encoded by this gene belongs to the glucagon family and is a preproprotein that is produced in the hypothalamus. The preproprotein is cleaved to form a 44 aa factor, also called somatocrinin, that acts to stimulate growth hormone release from the pituitary. Variant receptors for somatocrinin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. [provided by RefSeq, Jul 2008]

UniProt Comments for GHRH

GHRH: GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone. Belongs to the glucagon family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 20q11.2

Cellular Component: extracellular space; extracellular region; terminal button

Molecular Function: growth hormone-releasing hormone activity; growth hormone-releasing hormone receptor binding

Biological Process: positive regulation of insulin-like growth factor receptor signaling pathway; response to food; positive regulation of growth hormone secretion; growth hormone secretion; cAMP-mediated signaling; positive regulation of circadian sleep/wake cycle, REM sleep; cell-cell signaling; positive regulation of cell proliferation; positive regulation of cAMP biosynthetic process; adenohypophysis development; positive regulation of multicellular organism growth; G-protein signaling, adenylate cyclase activating pathway

Research Articles on GHRH

1. After 20 weeks of GHRH administration, gamma-aminobutyric acid levels are increased in all brain regions, N-acetylaspartylglutamate levels are increased in the dorsolateral frontal cortex, and myoinositol levels are decreased in the posterior cingulate.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GHRH active protein

Reference Product	PubMed Publications
TRH active protein	>249 publications with GHRH and TRH
CRH active protein	>152 publications with GHRH and CRH
POMC active protein	>151 publications with GHRH and POMC
GHRHR active protein	>54 publications with GHRH and GHRHR
SST active protein	>34 publications with GHRH and SST
PTH active protein	>27 publications with GHRH and PTH
ADCYAP1 active protein	>24 publications with GHRH and ADCYAP1
SCT active protein	>5 publications with GHRH and SCT
GCG active protein	>3 publications with GHRH and GCG
GHRL active protein	>2 publications with GHRH and GHRL

Pathways associated with GHRH active protein

Products by Pathway	Pathway Diagram
Class B/2 (Secretin Family Receptors) Pathway antibodies	Class B/2 (Secretin Family Receptors) Pathway Diagram
G Alpha (s) Signalling Events Pathway antibodies	G Alpha (s) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Glucagon-type Ligand Receptors Pathway antibodies	Glucagon-type Ligand Receptors Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By GPCR Pathway antibodies	Signaling By GPCR Pathway Diagram

Diseases associated with GHRH active protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>440 publications with GHRH and Neoplasms
Insulin Resistance Antibodies	>89 publications with GHRH and Insulin Resistance
Cardiovascular Diseases Antibodies	>68 publications with GHRH and Cardiovascular Diseases
Hyperplasia Antibodies	>62 publications with GHRH and Hyperplasia
Weight Gain Antibodies	>59 publications with GHRH and Weight Gain
Adenocarcinoma Antibodies	>57 publications with GHRH and Adenocarcinoma
Thyroid Diseases Antibodies	>52 publications with GHRH and Thyroid Diseases
Congenital Abnormalities Antibodies	>51 publications with GHRH and Congenital Abnormalities
Lung Neoplasms Antibodies	>48 publications with GHRH and Lung Neoplasms
Weight Loss Antibodies	>44 publications with GHRH and Weight Loss

Organs/Tissues associated with GHRH active protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>53 publications with GHRH and Lung
Mixed Antibodies	>30 publications with GHRH and Mixed