Hepatitis C Virus NS3, C33c, Aa1192-1459, Genotype 1b Recombinant Protein

The nonstructural protein NS3 of the hepatitis C virus (HCV) is indispensable for virus replication and a multifunctional enzyme that contains three catalytic activities such as serine protease, helicase, and NTPase. The N-terminal domain of the protein contains protease activity and the C-terminal domain contains nucleotide triphosphatase and RNA helicase activity. It has been shown that NS2/3 cleavage is mediated by NS2-3 protease, whereas NS3 serine protease is responsible for the other four cleavage sites of the nonstructural (NS) region. Immunoblot analysis on serum samples from 90 patients with chronic hepatitis C virus infection revealed four putative immunogenic regions within the NS3 protein of the virus: E (around aa 1250/ 1251), A (within aa 1250-1334), A/B (around aa 1323 and 1334), and B/C (around aa 1407 and 1412). Among them, region E was most immunodominant, and region A was recognized much less frequently by patients with cirrhosis than by those with chronic hepatitis.

Recombinant, from HCV subtype 1b. The protein contains the full-length HCV NS3 (c33c) immunodominant region, amino acids 1192-1459.

Small volumes of Hepatitis C Virus NS3, c33c, aa1192-1459, Genotype 1b recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS637414 is a recombinant protein targeting Hepatitis C Virus NS3, c33c, aa1192-1459, Genotype 1b. Also known as Hepatitis C Virus NS3, c33c, aa1192-1459, Genotype 1b, Recombinant (HCV). Host: E Coli.