PDE6D Recombinant Protein – Cat# MBS637425

P4072-06E: 15% SDS-PAGE (3ug)

Phosphodiesterase 6 Delta (PDE6D) Recombinant Protein

Name: PDE6D Recombinant Protein; MyBioSource
Brand: MyBioSource
SKU: MBS637425
Price: 755 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS637425

Human PDE6D was originally identified as a fourth subunit of rod-specific cGMP phosphodiesterase, PDE6. Catalytically active PDE6 is a heterodimer (ab) that is regulated by two inhibitory subunits. As PDE6D does not modify the catalytic properties of PDEab,… More details

$755 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Phosphodiesterase 6 delta (PDE6D), Recombinant Protein

Full Product Name

Phosphodiesterase 6 delta, Recombinant, Human (Phosphodiesterase 6D cGMP Specific Rod delta, PDE6 delta, PDE6D, PDED, GMP-PDE delta, Protein p17, Retinal Rod Rhodopsin Sensitive cGMP 3' 5' Cyclic Phosphodiesterase Subunit delta)

Product Gene Name

PDE6D recombinant protein

Sequence

MSAKDERARE ILRGFKLNWM NLRDAETGKI LWQGTEDLSV PGVEHEARVP KKILKCKAVS RELNFSSTEQ MEKFRLEQKV YFKGQCLEEW FFEFGFVIPN STNTWQSLIE AAPESQMMPA SVLTGNVIIE TKFFDDDLLV STSRVRLFYV GSHHHHHH

Host

E Coli

Form/Format

Supplied as a liquid in 20mM Tris HCl, pH 8.0, 1mM DTT, 100mM sodium chloride, 10% glycerol.

Purity/Purification

Highly Purified
~ 90% (SDS-PAGE). Purified by using conventional chromatography techniques.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

18.4kD

Chromosome Location

Chromosome: 2; NC_000002.11 (232597147..232645974, complement). Location: 2q35-q36

OMIM

602676

3D Structure

ModBase 3D Structure for O43924

Product Categories/Family for PDE6D recombinant protein

Molecular Biology; MB-Enzymes; Phosphodiesterase

Applications Tested/Suitable for PDE6D recombinant protein

Western Blot (WB)

Application Notes for PDE6D recombinant protein

Suitable for use in Western Blot.

Other Notes

Small volumes of PDE6D recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PDE6D purchase

MBS637425 is a recombinant protein targeting PDE6D. Also known as Phosphodiesterase 6 delta, Recombinant, Human (Phosphodiesterase 6D cGMP Specific Rod delta, PDE6 delta, PDE6D, PDED, GMP-PDE delta, Protein p17, Retinal Rod Rhodopsin Sensitive cGMP 3' 5' Cyclic Phosphodiesterase Subunit delta). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PDE6D. It may not necessarily be applicable to this product.

NCBI GI #

3294553

NCBI GeneID

5147

NCBI Accession #

AAC25953.1

UniProt Primary Accession #

O43924

UniProt Secondary Accession #

O43250

UniProt Related Accession #

O43924

NCBI Official Full Name

phosphodiesterase delta subunit

NCBI Official Synonym Full Names

phosphodiesterase 6D, cGMP-specific, rod, delta

NCBI Official Symbol

PDE6D

NCBI Official Synonym Symbols

PDED

UniProt Protein Name

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

UniProt Synonym Protein Names

Protein p17

Protein Family

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase

UniProt Gene Name

PDE6D

UniProt Synonym Gene Names

PDED; GMP-PDE delta

UniProt Entry Name

PDE6D_HUMAN

NCBI Protein Information

retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; protein p17; GMP-PDE delta

NCBI Summary for PDE6D

This gene encodes the delta subunit of rod-specific photoreceptor phosphodiesterase (PDE), a key enzyme in the phototransduction cascade. A similar protein in cow functions in solubilizing membrane-bound PDE. In addition to its role in the PDE complex, the encoded protein is thought to bind to prenyl groups of proteins to target them to subcellular organelles called cilia. Mutations in this gene are associated with Joubert syndrome-22. Alternative splicing results in multiple splice variants. [provided by RefSeq, Mar 2014]

UniProt Comments for PDE6D

PDE6D: Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation. Belongs to the PDE6D/unc-119 family.

Chromosomal Location of Human Ortholog: 2q35-q36

Cellular Component: cytoplasmic vesicle membrane; cytoskeleton; cytoplasmic vesicle; cytosol

Molecular Function: protein binding; 3',5'-cyclic-nucleotide phosphodiesterase activity; Rab GTPase binding; GTPase inhibitor activity

Biological Process: visual perception; metabolic process; organelle organization and biogenesis; response to stimulus; negative regulation of catalytic activity

Disease: Joubert Syndrome 22

Research Articles on PDE6D

1. findings indicate that ARL13B, INPP5E, PDE6D, and CEP164 form a distinct functional network that is involved in JBTS and NPHP but independent of the ones previously defined by NPHP and MKS proteins

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PDE6D recombinant protein

Reference Product	PubMed Publications
ARL2 recombinant protein	>3 publications with PDE6D and ARL2
GUCY2F recombinant protein	>1 publications with PDE6D and GUCY2F
ARL13B recombinant protein	>1 publications with PDE6D and ARL13B

Pathways associated with PDE6D recombinant protein

Products by Pathway	Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram

Diseases associated with PDE6D recombinant protein

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>3 publications with PDE6D and Disease Models, Animal
Neoplasms Antibodies	>1 publications with PDE6D and Neoplasms

Organs/Tissues associated with PDE6D recombinant protein

Organ/Tissue Name	Pubmed Publications
Eye Antibodies	>11 publications with PDE6D and Eye
Lung Antibodies	>2 publications with PDE6D and Lung
Spleen Antibodies	>1 publications with PDE6D and Spleen
Liver Antibodies	>1 publications with PDE6D and Liver
Kidney Antibodies	>1 publications with PDE6D and Kidney
Brain Antibodies	>1 publications with PDE6D and Brain