Hepatitis C Virus NS5, Aa2322-2423, Genotype 1a Recombinant Protein

Hepatitis C Virus (HCV), NS5, (aa2322-2423), genotype 1a, Recombinant. Contains the HCV NS5 Immunodominant region (aa2322-2423) with GST fusion partner. Immunoreactive with HCV positive sera.

Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000aa. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Several different genotypes of HCV with slightly different genomic sequences have since been identified that correlate with differences in response to treatment with interferon alpha. NS5A is a ~56kD pleiotropic protein with key roles in both viral RNA replication and modulation of the physiology of the host cell. It's exact role is not currently known (2008). NS5B (non-structural protein 5B) is an RNA-dependent RNA polymerase responsible for replication of the hepatitis C viral genome, and is currently a principal target for chemotherapeutic inhibition of HCV replication. Hepatitis C virus (HCV) can cause chronic hepatitis, cirrhosis and hepatocellular carcinoma. At present there is no vaccine effective against HCV.

Small volumes of Hepatitis C Virus NS5, aa2322-2423, Genotype 1a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS637480 is a recombinant protein targeting Hepatitis C Virus NS5, aa2322-2423, Genotype 1a. Also known as Hepatitis C Virus NS5, aa2322-2423, Genotype 1a, Recombinant (HCV). Host: E Coli.