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CTSL1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6375079

CTSL1 is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CTSL1, Polyclonal Antibody
Full Product Name
CTSL1 (Cathepsin L1, Major Excreted Protein, MEP, Cathepsin L1 Heavy Chain, Cathepsin L1 Light Chain, CTSL) (MaxLight 550)
Product Gene Name
anti-CTSL1 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human CTSL1. Species Crossreactivity: mouse.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Chromosome Location
chromosome: 9; Location:
OMIM
116880
3D Structure
ModBase 3D Structure for P07711
Immunogen
Full length human CTSL1, aa1-333 (NP_001903.1).
Immunogen Sequence
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
Conjugate
MaxLight550
Note
Preservative Free

Product Categories/Family for anti-CTSL1 antibody

Antibodies; Cathepsin
Applications Tested/Suitable for anti-CTSL1 antibody
Western Blot (WB)
Application Notes for anti-CTSL1 antibody
Applications are based on unconjugated antibody.

Other Notes

Small volumes of anti-CTSL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CTSL1 purchase

MBS6375079 is an antibody targeting CTSL1. Also known as CTSL1 (Cathepsin L1, Major Excreted Protein, MEP, Cathepsin L1 Heavy Chain, Cathepsin L1 Light Chain, CTSL) (MaxLight 550). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CTSL1. It may not necessarily be applicable to this product.

NCBI GI #
4503155
NCBI GeneID
1514
NCBI Accession #
NP_001903.1
UniProt Primary Accession #
P07711
UniProt Secondary Accession #
Q6IAV1; Q96QJ0
GenBank Nucleotide #
NM_001912.2
NCBI Official Full Name
cathepsin L1 preproprotein [Homo sapiens]
NCBI Official Synonym Full Names
cathepsin L1
NCBI Official Symbol
CTSL1
NCBI Official Synonym Symbols
MEP; CATL; CTSL; FLJ31037; CTSL1
UniProt Protein Name
Cathepsin L1
UniProt Synonym Protein Names
Major excreted protein
UniProt Gene Name
CTSL1
UniProt Synonym Gene Names
CTSL; MEP
UniProt Entry Name
CATL1_HUMAN

UniProt Comments for CTSL1

CTSL1: Important for the overall degradation of proteins in lysosomes. Belongs to the peptidase C1 family.

Protein type: Motility/polarity/chemotaxis; EC 3.4.22.15; Protease

Chromosomal Location of Human Ortholog: 9q21.33

Cellular Component: extracellular space; lysosomal lumen; lysosome; extracellular region; nucleus

Molecular Function: collagen binding; protein binding; proteoglycan binding; histone binding; fibronectin binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity

Biological Process: antigen processing and presentation; extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; adaptive immune response; proteolysis involved in cellular protein catabolic process; toll-like receptor signaling pathway; innate immune response; antigen processing and presentation of exogenous peptide antigen via MHC class II; proteolysis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CTSL1 antibody

 Reference Product  PubMed Publications
 CST3 antibody  >20 publications with CTSL1 and CST3
 CTSS antibody  >10 publications with CTSL1 and CTSS
 CSTA antibody  >5 publications with CTSL1 and CSTA
 IFI30 antibody  >1 publications with CTSL1 and IFI30
 CD74 antibody  >1 publications with CTSL1 and CD74

Pathways associated with anti-CTSL1 antibody

 Products by Pathway  Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Rheumatoid Arthritis Pathway antibodies  Rheumatoid Arthritis Pathway Diagram
 Rheumatoid Arthritis Pathway antibodies  Rheumatoid Arthritis Pathway Diagram

Diseases associated with anti-CTSL1 antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >51 publications with CTSL1 and Disease Models, Animal
 Nervous System Diseases Antibodies  >41 publications with CTSL1 and Nervous System Diseases
 Neoplasm Metastasis Antibodies  >29 publications with CTSL1 and Neoplasm Metastasis
 Inflammation Antibodies  >25 publications with CTSL1 and Inflammation
 Cardiovascular Diseases Antibodies  >24 publications with CTSL1 and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >23 publications with CTSL1 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >22 publications with CTSL1 and Kidney Diseases
 Liver Diseases Antibodies  >21 publications with CTSL1 and Liver Diseases
 Necrosis Antibodies  >18 publications with CTSL1 and Necrosis
 Proteinuria Antibodies  >15 publications with CTSL1 and Proteinuria

Organs/Tissues associated with anti-CTSL1 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >125 publications with CTSL1 and Liver
 Blood Antibodies  >119 publications with CTSL1 and Blood
 Kidney Antibodies  >74 publications with CTSL1 and Kidney
 Muscle Antibodies  >70 publications with CTSL1 and Muscle
 Brain Antibodies  >64 publications with CTSL1 and Brain
 Bone Antibodies  >58 publications with CTSL1 and Bone
 Spleen Antibodies  >33 publications with CTSL1 and Spleen
 Lung Antibodies  >31 publications with CTSL1 and Lung
 Skin Antibodies  >29 publications with CTSL1 and Skin
 Testis Antibodies  >25 publications with CTSL1 and Testis
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