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CXCR5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6375241

Chemokines play an important role in inflammation and critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be… More details

$1165 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CXCR5, Polyclonal Antibody
Full Product Name
CXCR5 (C-X-C Chemokine Receptor Type 5, CXC-R5, CXCR-5, Burkitt Lymphoma Receptor 1, Monocyte-derived Receptor 15, MDR-15, CD185, BLR1, MDR15) (HRP)
Product Gene Name
anti-CXCR5 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human BLR1.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
36,676 Da
OMIM
601613
3D Structure
ModBase 3D Structure for P32302
Immunogen
Full length human BLR1, aa1-372 (NP_001707.1).
Immunogen Sequence
MNYPLTLEMDLENLEDLFWELDRLDNYNDTSLVENHLCPATEGPLMASFKAVFVPVAYSLIFLLGVIGNVLVLVILERHRQTRSSTETFLFHLAVADLLLVFILPFAVAEGSVGWVLGTFLCKTVIALHKVNFYCSSLLLACIAVDRYLAIVHAVHAYRHRRLLSIHITCGTIWLVGFLLALPEILFAKVSQGHHNNSLPRCTFSQENQAETHAWFTSRFLYHVAGFLLPMLVMGWCYVGVVHRLRQAQRRPQRQKAVRVAILVTSIFFLCWSPYHIVIFLDTLARLKAVDNTCKLNGSLPVAITMCEFLGLAHCCLNPMLYTFAGVKFRSDLSRLLTKLGCTGPASLCQLFPSWRRSSLSESENATSLTTF
Conjugate
HRP
Note
Preservative Free

Product Categories/Family for anti-CXCR5 antibody

Antibodies; Receptors
Applications Tested/Suitable for anti-CXCR5 antibody
Western Blot (WB)
Application Notes for anti-CXCR5 antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CXCR5 antibody

Western Blot analysis of CXCR5 expression in transfected 293T cell line by CXCR5 polyclonal antibody. Lane 1: BLR1 transfected lysate (42kD). Lane 2: Non-transfected lysate.
Rabbit Anti-CXCR5 Polyclonal Antibody – Cat# MBS6375241

Testing Data of anti-CXCR5 antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between CXCR5 and GNAI2. HeLa cells were stained with CXCR5 rabbit purified polyclonal 1:1200 and GNAI2 mouse monoclonal antibody 1:50. Signals were detected by 30 Detection Kit 613 (red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex.
Rabbit Anti-CXCR5 Polyclonal Antibody, Testing Data – Cat# MBS6375241

Other Notes

Small volumes of anti-CXCR5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CXCR5 purchase

MBS6375241 is an antibody targeting CXCR5. Also known as CXCR5 (C-X-C Chemokine Receptor Type 5, CXC-R5, CXCR-5, Burkitt Lymphoma Receptor 1, Monocyte-derived Receptor 15, MDR-15, CD185, BLR1, MDR15) (HRP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CXCR5. It may not necessarily be applicable to this product.

NCBI GI #
4502415
NCBI GeneID
643
NCBI Accession #
NP_001707.1
UniProt Primary Accession #
P32302
UniProt Secondary Accession #
Q14811
UniProt Related Accession #
P32302
GenBank Nucleotide #
NM_001716
NCBI Official Full Name
C-X-C chemokine receptor type 5 isoform 1
NCBI Official Synonym Full Names
chemokine (C-X-C motif) receptor 5
NCBI Official Symbol
CXCR5
NCBI Official Synonym Symbols
BLR1; CD185; MDR15
UniProt Protein Name
C-X-C chemokine receptor type 5
UniProt Synonym Protein Names
Burkitt lymphoma receptor 1; Monocyte-derived receptor 15; MDR-15; CD_antigen: CD185
Protein Family
C-X-C chemokine receptor
UniProt Gene Name
CXCR5
UniProt Synonym Gene Names
BLR1; MDR15; CXC-R5; CXCR-5; MDR-15
UniProt Entry Name
CXCR5_HUMAN
NCBI Protein Information
C-X-C chemokine receptor type 5; CXC-R5; CXCR-5; MDR-15; monocyte-derived receptor 15; Burkitt lymphoma receptor 1, GTP-binding protein; Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5)

NCBI Summary for CXCR5

This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
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UniProt Comments for CXCR5

CXCR5: Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function: G-protein coupled receptor activity; protein binding; C-X-C chemokine receptor activity

Biological Process: positive regulation of cytokinesis; G-protein coupled receptor protein signaling pathway; B cell activation; immune response; cell motility; chemotaxis; lymph node development
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Research Articles on CXCR5

1. 11q23.3 with rs4938573 near CXCR5 gene is associated with follicular lymphoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CXCR5 antibody

 Reference Product  PubMed Publications
 CXCL13 antibody  >187 publications with CXCR5 and CXCL13
 CCL19 antibody  >31 publications with CXCR5 and CCL19
 CCL21 antibody  >28 publications with CXCR5 and CCL21
 CCL5 antibody  >14 publications with CXCR5 and CCL5
 CCL20 antibody  >13 publications with CXCR5 and CCL20
 CCL25 antibody  >4 publications with CXCR5 and CCL25
 CCL28 antibody  >2 publications with CXCR5 and CCL28
 CCL27 antibody  >1 publications with CXCR5 and CCL27

Pathways associated with anti-CXCR5 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram

Diseases associated with anti-CXCR5 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >79 publications with CXCR5 and Inflammation
 Necrosis Antibodies  >41 publications with CXCR5 and Necrosis
 Nervous System Diseases Antibodies  >37 publications with CXCR5 and Nervous System Diseases
 Disease Models, Animal Antibodies  >33 publications with CXCR5 and Disease Models, Animal
 Carcinoma Antibodies  >19 publications with CXCR5 and Carcinoma
 Kidney Diseases Antibodies  >18 publications with CXCR5 and Kidney Diseases
 Lung Diseases Antibodies  >17 publications with CXCR5 and Lung Diseases
 Neoplasms, Experimental Antibodies  >15 publications with CXCR5 and Neoplasms, Experimental
 Skin Diseases Antibodies  >14 publications with CXCR5 and Skin Diseases
 Liver Diseases Antibodies  >12 publications with CXCR5 and Liver Diseases

Organs/Tissues associated with anti-CXCR5 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >493 publications with CXCR5 and Blood
 Lymph Node Antibodies  >198 publications with CXCR5 and Lymph Node
 Lymph Antibodies  >110 publications with CXCR5 and Lymph
 Spleen Antibodies  >74 publications with CXCR5 and Spleen
 Pharynx Antibodies  >29 publications with CXCR5 and Pharynx
 Thymus Antibodies  >25 publications with CXCR5 and Thymus
 Lung Antibodies  >22 publications with CXCR5 and Lung
 Skin Antibodies  >16 publications with CXCR5 and Skin
 Intestine Antibodies  >14 publications with CXCR5 and Intestine
 Prostate Antibodies  >11 publications with CXCR5 and Prostate
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