Frizzled 8, Fc Chimera Active Protein

Members of the Frizzled family of proteins serve as receptors for the Wnt signaling pathway. The founding member of this family was identified in Drosophilia based on its role in tissue polarity in the adult cuticle and named for the disorganized appearance of bristle hairs on the mutant. Mouse Frizzled-8 (mFrz-8) was originally cloned in a PCR screen to identify additional Frizzled family members in vertebrates. There are nine murine Frizzled genes and 10 human Frizzled genes identified to date. The predicted structure of Frizzled proteins is similar among all family members, containing a divergent N-terminal signal peptide, a highly conserved extracellular cysteine-rich domain, a seven-pass transmembrane region, and a variable-length C-terminal tail. The most conserved regions of the Frizzled proteins are the extracellular cysteine-rich domain (CRD) which spans approximately 120aa residues and contains 10 invariant cysteines, and the seven transmembrane domains. Mouse Frizzled-8 is 685 aa residues long and shows 95% and 82% amino acid identity to human and Xenopus Frizzled-8, respectively. Like other family members, Frizzled-8 has a complex expression pattern in the mouse embryo. It is expressed in the neural tube, brain, eye, somites, gut and bronchial arches. One of the best-characterized Wnt signal transduction pathways is the canonical Wnt/b-catenin pathway. It is involved in diverse biological mechanisms such as dorsal/ventral development in Xenopus embryos and mammalian tumor formation, acting via stabilization of b-catenin. Frizzled-8 is implicated in this pathway based on its ability to bind Wnt ligands that stimulate b-catenin stabilization and to influence the formation of secondary axes in Xenopus embryos. The mFrz-8 CRD has been demonstrated to bind cell surface Xenopus Wnt-8 (Xwnt-8) protein, indicating that this region is sufficient for binding ligand.

Small volumes of Frizzled 8, Fc Chimera active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS637547 is an active protein targeting Frizzled 8, Fc Chimera. Also known as Frizzled 8, Fc Chimera, Recombinant, Mouse (FZD8).