HSPA8 Recombinant Protein – Cat# MBS637752

Heat Shock Cognate Protein 70, Rat (HSPA8) Recombinant Protein

Name: HSPA8 Recombinant Protein; MyBioSource
Brand: MyBioSource
SKU: MBS637752
Price: 755 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS637752

Hsc70-interacting protein (Hip) is a cytosolic protein that exists as a homo-oligomer and participates in the regulation of the heat shock protein Hsc70 in eukaryotic cells (1). Hip Rat Hip has a carboxyl terminal addition of residues GSEQKLISEEDL, which… More details

$755 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Heat Shock Cognate Protein 70, Rat (Hspa8), Recombinant Protein

Full Product Name

Heat Shock Cognate Protein 70, Recombinant, Rat (Hsc70-interacting protein, Hip, HSC70, Heat Shock Protein 73, HSP73)

Product Gene Name

Hspa8 recombinant protein

Host

E Coli

Form/Format

Supplied as a liquid in 20mM MOPS pH 7.2, 50mM KCl, 2mM MgCl2.

Purity/Purification

Highly Purified
85% as determined by SDS-PAGE analysis.

Preparation and Storage

For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 12 months.

Molecular Weight

~44kD

Chromosome Location

Chromosome: 8; NC_005107.3 (43478238..43480456). Location: 8q22

3D Structure

ModBase 3D Structure for P63018

Product Categories/Family for Hspa8 recombinant protein

Molecular Biology; MB-Heat Shock Proteins

Other Notes

Small volumes of Hspa8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Hspa8 purchase

MBS637752 is a recombinant protein targeting Hspa8. Also known as Heat Shock Cognate Protein 70, Recombinant, Rat (Hsc70-interacting protein, Hip, HSC70, Heat Shock Protein 73, HSP73). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for Hspa8. It may not necessarily be applicable to this product.

NCBI GI #

13242237

NCBI GeneID

24468

NCBI Accession #

NP_077327.1

UniProt Primary Accession #

P63018

UniProt Secondary Accession #

P08109; P12225; Q4FZY7; Q62373; Q62374; Q62375

UniProt Related Accession #

P63018

GenBank Nucleotide #

NM_024351.2

NCBI Official Full Name

heat shock cognate 71 kDa protein

NCBI Official Synonym Full Names

heat shock 70kDa protein 8

NCBI Official Symbol

Hspa8

NCBI Official Synonym Symbols

Hsc70

UniProt Protein Name

Heat shock cognate 71 kDa protein

UniProt Synonym Protein Names

Heat shock 70 kDa protein 8

UniProt Gene Name

Hspa8

UniProt Synonym Gene Names

Hsc70; Hsc73

UniProt Entry Name

HSP7C_RAT

NCBI Protein Information

heat shock cognate 71 kDa protein; heat shock protein 8; heat shock protein A8; heat shock 70kD protein 8; Heat shock cognate protein 70

NCBI Summary for Hspa8

member of the hsp70 protein; expressed in unstressed cells [RGD, Feb 2006]

UniProt Comments for Hspa8

HSC70: Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co- chaperones. Interacts with HSPH1/HSP105. Interacts with IRAK1BP1. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with PACRG and TSC2. Interacts with BAG1. Interacts with SV40 VP1. Interacts with DNAJC7. Interacts with HERC5. Interacts with CITED1 (via N-terminus); the interaction suppresses the association of CITED1 to p300/CBP and Smad-mediated transcription transactivation. Constitutively synthesized. Ubiquitous. Belongs to the heat shock protein 70 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding; Heat shock protein; Chaperone; Nucleolus

Cellular Component: extracellular space; neuron projection; focal adhesion; protein complex; terminal button; cytosol; ribonucleoprotein complex; spliceosome; synaptic vesicle; cell soma; membrane; cytoplasm; plasma membrane; nucleolus; melanosome; intracellular; nucleus; myelin sheath; ubiquitin ligase complex

Molecular Function: protein binding; enzyme binding; G-protein-coupled receptor binding; heat shock protein binding; ubiquitin protein ligase binding; unfolded protein binding; ATPase activity; ATPase activity, coupled; ADP binding; ATP binding; receptor binding

Biological Process: positive regulation of nuclear mRNA splicing, via spliceosome; protein folding; transcription, DNA-dependent; chaperone cofactor-dependent protein folding; regulation of cell cycle; RNA splicing; protein refolding; mRNA processing; negative regulation of transcription, DNA-dependent

Research Articles on Hspa8

1. The level of 70 kDa heat shock cognate (HSC70) expression was greater in the diencephalon of the 3 ppm Fe group.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Hspa8 recombinant protein

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Antigen Processing And Presentation Pathway antibodies	Antigen Processing And Presentation Pathway Diagram
Antigen Processing And Presentation Pathway antibodies	Antigen Processing And Presentation Pathway Diagram
Diurnally Regulated Genes With Circadian Orthologs Pathway antibodies	Diurnally Regulated Genes With Circadian Orthologs Pathway Diagram
Endocytosis Pathway antibodies	Endocytosis Pathway Diagram
Endocytosis Pathway antibodies	Endocytosis Pathway Diagram
Epstein-Barr Virus Infection Pathway antibodies	Epstein-Barr Virus Infection Pathway Diagram
Epstein-Barr Virus Infection Pathway antibodies	Epstein-Barr Virus Infection Pathway Diagram
Estrogen Signaling Pathway antibodies	Estrogen Signaling Pathway Diagram
Estrogen Signaling Pathway antibodies	Estrogen Signaling Pathway Diagram
Influenza A Pathway antibodies	Influenza A Pathway Diagram

Diseases associated with Hspa8 recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>68 publications with Hspa8 and Neoplasms
Nervous System Diseases Antibodies	>51 publications with Hspa8 and Nervous System Diseases
Brain Diseases Antibodies	>37 publications with Hspa8 and Brain Diseases
Cardiovascular Diseases Antibodies	>25 publications with Hspa8 and Cardiovascular Diseases
Disease Models, Animal Antibodies	>24 publications with Hspa8 and Disease Models, Animal
Fibrosis Antibodies	>16 publications with Hspa8 and Fibrosis
Heart Diseases Antibodies	>16 publications with Hspa8 and Heart Diseases
Necrosis Antibodies	>14 publications with Hspa8 and Necrosis
Inflammation Antibodies	>12 publications with Hspa8 and Inflammation
Liver Diseases Antibodies	>10 publications with Hspa8 and Liver Diseases

Organs/Tissues associated with Hspa8 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>91 publications with Hspa8 and Brain
Heart Antibodies	>35 publications with Hspa8 and Heart
Lung Antibodies	>13 publications with Hspa8 and Lung
Eye Antibodies	>11 publications with Hspa8 and Eye
Ovary Antibodies	>8 publications with Hspa8 and Ovary
Testis Antibodies	>7 publications with Hspa8 and Testis
Embryonic Tissue Antibodies	>6 publications with Hspa8 and Embryonic Tissue
Prostate Antibodies	>3 publications with Hspa8 and Prostate
Connective Tissue Antibodies	>3 publications with Hspa8 and Connective Tissue
Cervix Antibodies	>2 publications with Hspa8 and Cervix