SCFB-Trcp1 Complex, Active (SCFB) Human Recombinant Protein

The SCF complexes represent the largest family of ubiquitin-protein ligases and mediate the ubiquitination of a broad spectrum of regulatory and signalling proteins in diverse cellular pathways. The SCF consists of three invariant components, Skp1, Cul1, and Rbx1 and an interchangeable subunit, an F-box protein which is responsible for recruiting specific substrates to be ubiquitinated by the SCF. SCFBTrCP1 mediates the ubiquitination and subsequent proteasomal degradation of a variety of proteins involved in various cellular processes, these include IkBa, an inhibitor of the transcription factor NFkB and B-catenin which is involved in the Wnt signalling pathway. A number of cancers, including those in breast, colon and pancreatic tissue have been associated with the deregulation of SCFBTrCP1.

Small volumes of SCFB-TrCP1 Complex, Active recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS637754 is a recombinant protein targeting SCFB-TrCP1 Complex, Active. Also known as SCFB-TrCP1 Complex, Active, Recombinant, Human (SCF-B-TrCP,SCFFWD10). Reactive in Human.