Rabbit Anti-ESRRA Polyclonal Antibody – Cat# MBS6377725

Western Blot analysis of ESRRA expression in transfected 293T cell line by ESRRA polyclonal antibody. Lane 1: ESRRA transfected lysate (45.5kD). Lane 2: Non-transfected lysate.

ESRRA Antibody – Rabbit Polyclonal

Name: ESRRA Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6377725
Price: 1165 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6377725

ESRRA is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact.… More details

$1165 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ESRRA, Polyclonal Antibody

Full Product Name

ESRRA (Steroid Hormone Receptor ERR1, Estrogen-related Receptor, alpha, ERR-alpha, Estrogen Receptor-like 1, Nuclear Receptor Subfamily 3 Group B Member 1, NR3B1, ESRL1, ERR1) (Biotin)

Product Gene Name

anti-ESRRA antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Specificity

Recognizes human ESRRA.

Preparation and Storage

Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

OMIM

601998

3D Structure

ModBase 3D Structure for P11474

Immunogen

Full length human ESRRA, aa1-423 (NP_004442.3).

Immunogen Sequence

MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVALAPGPAPTRCLPGHKEEEDGEGAGPGEQGGGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAAPVNALVSHLLVVEPEKLYAMPDPAGPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGELGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEAMMD

Conjugate

Biotin

Note

Preservative Free

Product Categories/Family for anti-ESRRA antibody

Antibodies; Receptors

Applications Tested/Suitable for anti-ESRRA antibody

Western Blot (WB)

Application Notes for anti-ESRRA antibody

Applications are based on unconjugated antibody.

Other Notes

Small volumes of anti-ESRRA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ESRRA purchase

MBS6377725 is an antibody targeting ESRRA. Also known as ESRRA (Steroid Hormone Receptor ERR1, Estrogen-related Receptor, alpha, ERR-alpha, Estrogen Receptor-like 1, Nuclear Receptor Subfamily 3 Group B Member 1, NR3B1, ESRL1, ERR1) (Biotin). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ESRRA. It may not necessarily be applicable to this product.

NCBI GI #

18860920

NCBI GeneID

2101

NCBI Accession #

NP_004442.3

UniProt Primary Accession #

P11474

UniProt Related Accession #

P11474

GenBank Nucleotide #

NM_004451.3

NCBI Official Full Name

steroid hormone receptor ERR1 isoform 1

NCBI Official Synonym Full Names

estrogen related receptor alpha

NCBI Official Symbol

ESRRA

NCBI Official Synonym Symbols

ERR1; ERRa; ESRL1; NR3B1; ERRalpha

UniProt Protein Name

Steroid hormone receptor ERR1

UniProt Synonym Protein Names

Estrogen receptor-like 1; Estrogen-related receptor alpha; ERR-alpha; Nuclear receptor subfamily 3 group B member 1

Protein Family

Steroid hormone receptor

UniProt Gene Name

ESRRA

UniProt Synonym Gene Names

ERR1; ESRL1; NR3B1; ERR-alpha

UniProt Entry Name

ERR1_HUMAN

NCBI Protein Information

steroid hormone receptor ERR1

NCBI Summary for ESRRA

The protein encoded by this gene is a nuclear receptor that is most closely related to the estrogen receptor. This protein acts as a site-specific transcription factor and interacts with members of the PGC-1 family of transcription cofactors to regulate the expression of most genes involved in cellular energy production as well as in the process of mitochondrial biogenesis. A processed pseudogene of ESRRA is located on chromosome 13q12.1. [provided by RefSeq, Jun 2019]

UniProt Comments for ESRRA

ERR1: Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Belongs to the nuclear hormone receptor family. NR3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: microtubule cytoskeleton; nucleoplasm; intercellular bridge; nucleolus; nucleus

Molecular Function: protein domain specific binding; ligand-dependent nuclear receptor activity; protein binding; DNA binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; steroid binding

Biological Process: transcription initiation from RNA polymerase II promoter; mitochondrion organization and biogenesis; intracellular receptor-mediated signaling pathway; regulation of osteoblast differentiation; organelle organization and biogenesis; negative regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; regulation of osteoclast differentiation; regulation of transcription, DNA-dependent; cartilage development; gene expression; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter

Research Articles on ESRRA

1. Low ERRA expression is associated with development of hepatic cellular carcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ESRRA antibody

Reference Product	PubMed Publications
PPARGC1A antibody	>5 publications with ESRRA and PPARGC1A
ESRRB antibody	>1 publications with ESRRA and ESRRB
PPARA antibody	>1 publications with ESRRA and PPARA
ESR1 antibody	>1 publications with ESRRA and ESR1

Pathways associated with anti-ESRRA antibody

Products by Pathway	Pathway Diagram
Energy Metabolism Pathway antibodies	Energy Metabolism Pathway Diagram
Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies	Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Generic Transcription Pathway antibodies	Generic Transcription Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram
Mitochondrial Gene Expression Pathway antibodies	Mitochondrial Gene Expression Pathway Diagram
Mitochondrial Biogenesis Pathway antibodies	Mitochondrial Biogenesis Pathway Diagram
Nuclear Receptor Transcription Pathway antibodies	Nuclear Receptor Transcription Pathway Diagram
Nuclear Receptors Pathway antibodies	Nuclear Receptors Pathway Diagram

Diseases associated with anti-ESRRA antibody

Disease Name	Pubmed Publications
Ovarian Neoplasms Antibodies	>4 publications with ESRRA and Ovarian Neoplasms
Adenocarcinoma Antibodies	>3 publications with ESRRA and Adenocarcinoma
Nervous System Diseases Antibodies	>3 publications with ESRRA and Nervous System Diseases
Metabolic Diseases Antibodies	>3 publications with ESRRA and Metabolic Diseases
Fatty Liver Antibodies	>2 publications with ESRRA and Fatty Liver
Uterine Neoplasms Antibodies	>2 publications with ESRRA and Uterine Neoplasms
Liver Diseases Antibodies	>1 publications with ESRRA and Liver Diseases
Fibrosis Antibodies	>1 publications with ESRRA and Fibrosis
Endometrial Neoplasms Antibodies	>1 publications with ESRRA and Endometrial Neoplasms
Weight Loss Antibodies	>1 publications with ESRRA and Weight Loss

Organs/Tissues associated with anti-ESRRA antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>5 publications with ESRRA and Blood
Brain Antibodies	>4 publications with ESRRA and Brain
Bone Antibodies	>3 publications with ESRRA and Bone
Liver Antibodies	>3 publications with ESRRA and Liver
Embryonic Tissue Antibodies	>3 publications with ESRRA and Embryonic Tissue
Heart Antibodies	>2 publications with ESRRA and Heart
Thyroid Antibodies	>2 publications with ESRRA and Thyroid
Spleen Antibodies	>1 publications with ESRRA and Spleen
Prostate Antibodies	>1 publications with ESRRA and Prostate
Lung Antibodies	>1 publications with ESRRA and Lung