IL8 Recombinant Protein – Cat# MBS637776

Interleukin 8, Aa1-77 (IL8) Recombinant Protein

Name: IL8 Recombinant Protein; Interleukin 8, Aa1-77; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS637776
Price: 610 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS637776

Recombinant Human IL-8 is a single, non-glycosylated polypeptide chain containing 77a and having a molecular weight of ~8.9kD. The sequence of the first five N-terminal amino acids was determined to be Ser-Ala-Lys-Glu-Leu. Contains less than 1% dimers and… More details

$610 / 0.025 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Interleukin 8, aa1-77 (IL8), Recombinant Protein

Full Product Name

Interleukin 8, aa1-77, Recombinant, Human (IL-8)

Product Gene Name

IL8 recombinant protein

Host

E Coli

Form/Format

Supplied as a lyophilized powder in H2O containing no additives. No preservative added. Reconstitute with sterile deionized water to a concentration 100ug/ml.

Purity/Purification

Purified
98% (HPLC, FPLC, SDS-PAGE).

Preparation and Storage

Lyophilized powder may be stored at 4 degree C for short-term only. Stable for at least 6 months at -20 degree C. Reconstitute with sterile deionized water to a concentration 100ug/ml. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

~8.9kD

Chromosome Location

Chromosome: 4; NC_000004.11 (74606223..74609433). Location: 4q13-q21

OMIM

146930

3D Structure

ModBase 3D Structure for P10145

Endotoxin Level

0.1ng/ug

Activity:
Specific activity of Human IL-8 determined in chemotaxis of donor PBL neutrophils with threshold concentration corresponding to 25-150ng/ml.

Product Categories/Family for IL8 recombinant protein

Growth Factors; Cytokines; Growth Factors-Interleukin

Applications Tested/Suitable for IL8 recombinant protein

ELISA (EL/EIA)

Other Notes

Small volumes of IL8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL8 purchase

MBS637776 is a recombinant protein targeting IL8. Also known as Interleukin 8, aa1-77, Recombinant, Human (IL-8). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL8. It may not necessarily be applicable to this product.

NCBI GI #

10834978

NCBI GeneID

3576

NCBI Accession #

NP_000575.1

UniProt Primary Accession #

P10145

UniProt Secondary Accession #

Q6FGF6; Q6LAE6; Q96RG6; Q9C077; Q9UCE1; Q9UCR8; Q9UCR9; Q9UCS0; B2R4L8

UniProt Related Accession #

P10145

GenBank Nucleotide #

NM_000584.3

NCBI Official Full Name

interleukin-8

NCBI Official Synonym Full Names

interleukin 8

NCBI Official Symbol

IL8

NCBI Official Synonym Symbols

NAF; GCP1; LECT; LUCT; NAP1; CXCL8; GCP-1; LYNAP; MDNCF; MONAP; NAP-1

UniProt Protein Name

Interleukin-8

UniProt Synonym Protein Names

C-X-C motif chemokine 8; Emoctakin; Granulocyte chemotactic protein 1; GCP-1; Monocyte-derived neutrophil chemotactic factor; MDNCF; Monocyte-derived neutrophil-activating peptide; MONAP; Neutrophil-activating protein 1; NAP-1; Protein 3-10C; T-cell chemotactic factorCleaved into the following 7 chains:MDNCF-a; Alternative name(s):; GCP/IL-8 protein IV; IL8/NAP1 form IInterleukin-8; Alternative name(s):; (Ala-IL-8)77; GCP/IL-8 protein II; IL-8(1-77); IL8/NAP1 form II; MDNCF-bIL-8(5-77)IL-8(6-77); Alternative name(s):; (Ser-IL-8)72; GCP/IL-8 protein I; IL8/NAP1 form III; Lymphocyte-derived neutrophil-activating factor; LYNAP; MDNCF-c; Neutrophil-activating factor; NAFIL-8(7-77); Alternative name(s):; GCP/IL-8 protein V; IL8/NAP1 form IVIL-8(8-77); Alternative name(s):; GCP/IL-8 protein VI; IL8/NAP1 form VIL-8(9-77); Alternative name(s):; GCP/IL-8 protein III; IL8/NAP1 form VI

UniProt Gene Name

IL8

UniProt Synonym Gene Names

CXCL8; IL-8; GCP-1; MDNCF; MONAP; NAP-1; LYNAP; NAF

UniProt Entry Name

IL8_HUMAN

NCBI Protein Information

interleukin-8; emoctakin; T-cell chemotactic factor; neutrophil-activating peptide 1; chemokine (C-X-C motif) ligand 8; beta-thromboglobulin-like protein; granulocyte chemotactic protein 1; tumor necrosis factor-induced gene 1; alveolar macrophage chemotactic factor I; monocyte-derived neutrophil chemotactic factor; monocyte-derived neutrophil-activating peptide; small inducible cytokine subfamily B, member 8; lymphocyte derived neutrophil activating peptide; lung giant cell carcinoma-derived chemotactic protein; beta endothelial cell-derived neutrophil activating peptide

NCBI Summary for IL8

The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008]

UniProt Comments for IL8

IL8: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively. Belongs to the intercrine alpha (chemokine CxC) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cytokine; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q13-q21

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; chemokine activity; interleukin-8 receptor binding

Biological Process: regulation of cell adhesion; neutrophil chemotaxis; neutrophil activation; unfolded protein response; negative regulation of G-protein coupled receptor protein signaling pathway; calcium-mediated signaling; signal transduction; chemotaxis; regulation of retroviral genome replication; induction of positive chemotaxis; negative regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; response to molecule of bacterial origin; receptor internalization; immune response; angiogenesis; inflammatory response; cell motility; cell cycle arrest; embryonic gut development

Research Articles on IL8

1. IL-8 has negative correlation with Glasgow coma scale and Glasgow Outcome Scale indiffuse axonal injury

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with IL8 recombinant protein

Products by Pathway	Pathway Diagram
ATF-2 Transcription Factor Network Pathway antibodies	ATF-2 Transcription Factor Network Pathway Diagram
Activation Of Genes By ATF4 Pathway antibodies	Activation Of Genes By ATF4 Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Bladder Cancer Pathway antibodies	Bladder Cancer Pathway Diagram
Bladder Cancer Pathway antibodies	Bladder Cancer Pathway Diagram
Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies	Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
Chagas Disease (American Trypanosomiasis) Pathway antibodies	Chagas Disease (American Trypanosomiasis) Pathway Diagram
Chagas Disease (American Trypanosomiasis) Pathway antibodies	Chagas Disease (American Trypanosomiasis) Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram

Diseases associated with IL8 recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>683 publications with IL8 and Inflammation
Necrosis Antibodies	>400 publications with IL8 and Necrosis
Hypersensitivity Antibodies	>67 publications with IL8 and Hypersensitivity
Adenocarcinoma Antibodies	>49 publications with IL8 and Adenocarcinoma
Pulmonary Disease, Chronic Obstructive Antibodies	>48 publications with IL8 and Pulmonary Disease, Chronic Obstructive
Pneumonia Antibodies	>34 publications with IL8 and Pneumonia
Colorectal Neoplasms Antibodies	>30 publications with IL8 and Colorectal Neoplasms
Kidney Diseases Antibodies	>27 publications with IL8 and Kidney Diseases
Breast Neoplasms Antibodies	>26 publications with IL8 and Breast Neoplasms
Stomach Neoplasms Antibodies	>21 publications with IL8 and Stomach Neoplasms

Organs/Tissues associated with IL8 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>679 publications with IL8 and Blood
Lung Antibodies	>238 publications with IL8 and Lung
Vascular Antibodies	>204 publications with IL8 and Vascular
Intestine Antibodies	>91 publications with IL8 and Intestine
Skin Antibodies	>83 publications with IL8 and Skin
Liver Antibodies	>72 publications with IL8 and Liver
Heart Antibodies	>68 publications with IL8 and Heart
Bone Antibodies	>61 publications with IL8 and Bone
Muscle Antibodies	>59 publications with IL8 and Muscle
Brain Antibodies	>48 publications with IL8 and Brain