Sulfotransferase 1a1 (SULT1A1) Active Protein

Name: SULT1A1 Active Protein; Sulfotransferase 1a1; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS637872
Price: 1055 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS637872

Recombinant enzyme corresponding to Glu2-Leu295 with a N-terminal Met and 6 His tag of human Sulfotransferase 1A1 expressed in E. coli. Cytosolic sulfotransferases catalyze the sulfonation of many hormones, neurotransmitters, drugs, and xenobiotic compounds.… More details

$1055 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Sulfotransferase 1A1 (SULT1A1), Active Protein

Full Product Name

Sulfotransferase 1A1, Recombinant, Human (SULT1A1, Aryl sulfotransferase 1, HAST1/HAST2, OK/SW-cl.88, Phenol-sulfating phenol sulfotransferase 1, Phenol sulfotransferase 1, P-PST 1, ST1A3, STP, STP1, Sulfotransferase 1A1, Thermostable phenol sulfotransfer

Product Gene Name

SULT1A1 active protein

Product Synonym Names

Host

E Coli

Form/Format

Supplied as a liquid in 25mM Tris, pH 7.5, 150mM sodium chloride, 5mM DTT.

Purity/Purification

>95% by SDS-PAGE under reducing conditions and visualized by silver stain.

Concentration

0.882mg/ml (lot specific)

Preparation and Storage

Aliquot to avoid repeated freezing and thawing and store at -70 degree C. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Shipping: Ships with Dry Ice.

Molecular Weight

Predicted Molecular Mass: 35kD
SDS-PAGE: 34kD, reducing conditions

Chromosome Location

Chromosome: 16; NC_000016.9 (28616908..28634907, complement). Location: 16p12.1

OMIM

171150

3D Structure

ModBase 3D Structure for P50225

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

N-terminal Sequence Analysis

His

SDS-PAGE

34kD, reducing conditions

Activity

Measured by its ability to transfer sulfate from PAPS to 1-Napthol.

Specific Activity

>30 pmol/min/ug

Endotoxin Level

1.0 EU per 1ug (LAL).

Dry Ice Shipment

Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Product Categories/Family for SULT1A1 active protein

Molecular Biology; MB-Enzymes; Sulfotransferase

Applications Tested/Suitable for SULT1A1 active protein

Western Blot (WB)

Application Notes for SULT1A1 active protein

Other applications not tested. Optimal dilutions to be determined by the researcher.

Other Notes

Small volumes of SULT1A1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SULT1A1 purchase

MBS637872 is an active protein targeting SULT1A1. Also known as Sulfotransferase 1A1, Recombinant, Human (SULT1A1, Aryl sulfotransferase 1, HAST1/HAST2, OK/SW-cl.88, Phenol-sulfating phenol sulfotransferase 1, Phenol sulfotransferase 1, P-PST 1, ST1A3, STP, STP1, Sulfotransferase 1A1, Thermostable phenol sulfotransfer. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for SULT1A1. It may not necessarily be applicable to this product.

NCBI GI #

29540543

NCBI GeneID

6817

NCBI Accession #

NP_803880.1

UniProt Primary Accession #

P50225

UniProt Secondary Accession #

Q2NL71; Q86U58; Q92818; Q9BVU6; Q9UGG7

UniProt Related Accession #

P50225

GenBank Nucleotide #

NM_177536.3

NCBI Official Full Name

sulfotransferase 1A1 isoform b

NCBI Official Synonym Full Names

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

NCBI Official Symbol

SULT1A1

NCBI Official Synonym Symbols

PST; STP; STP1; P-PST; ST1A1; ST1A3; TSPST1; HAST1/HAST2

UniProt Protein Name

Sulfotransferase 1A1

UniProt Synonym Protein Names

Aryl sulfotransferase 1; HAST1/HAST2; Phenol sulfotransferase 1; Phenol-sulfating phenol sulfotransferase 1; P-PST 1; ST1A3; Thermostable phenol sulfotransferase

Protein Family

Sulfotransferase

UniProt Gene Name

SULT1A1

UniProt Synonym Gene Names

STP; STP1; ST1A1; P-PST 1; Ts-PST

UniProt Entry Name

ST1A1_HUMAN

NCBI Protein Information

sulfotransferase 1A1; ts-PST; P-PST 1; aryl sulfotransferase 1; thermostable phenol sulfotransferase1; phenol-sulfating phenol sulfotransferase 1

NCBI Summary for SULT1A1

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for SULT1A1

SULT1A1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N- hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk. Belongs to the sulfotransferase 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.8.2.1; Energy Metabolism - sulfur; Transferase

Chromosomal Location of Human Ortholog: 16p12.1

Cellular Component: cytosol

Molecular Function: sulfotransferase activity; steroid sulfotransferase activity; flavonol 3-sulfotransferase activity; aryl sulfotransferase activity

Biological Process: estrogen metabolic process; flavonoid metabolic process; xenobiotic metabolic process; sulfation; catecholamine metabolic process; amine metabolic process; 3'-phosphoadenosine 5'-phosphosulfate metabolic process

Research Articles on SULT1A1

1. SULT1A1 variant allele increases breast cancer risk among subjects who were exposed to high smoked meat intake.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SULT1A1 active protein

Reference Product	PubMed Publications
SULT1A2 active protein	>53 publications with SULT1A1 and SULT1A2
UGT1A1 active protein	>37 publications with SULT1A1 and UGT1A1
UGT1A6 active protein	>13 publications with SULT1A1 and UGT1A6
UGT2B15 active protein	>10 publications with SULT1A1 and UGT2B15
PAPSS2 active protein	>3 publications with SULT1A1 and PAPSS2
PAPSS1 active protein	>1 publications with SULT1A1 and PAPSS1

Pathways associated with SULT1A1 active protein

Products by Pathway	Pathway Diagram
Arylamine Metabolism Pathway antibodies	Arylamine Metabolism Pathway Diagram
Biological Oxidations Pathway antibodies	Biological Oxidations Pathway Diagram
Chemical Carcinogenesis Pathway antibodies	Chemical Carcinogenesis Pathway Diagram
Chemical Carcinogenesis Pathway antibodies	Chemical Carcinogenesis Pathway Diagram
Cytosolic Sulfonation Of Small Molecules Pathway antibodies	Cytosolic Sulfonation Of Small Molecules Pathway Diagram
Estrogen Metabolism Pathway antibodies	Estrogen Metabolism Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Phase II Conjugation Pathway antibodies	Phase II Conjugation Pathway Diagram
Sulfation Biotransformation Reaction Pathway antibodies	Sulfation Biotransformation Reaction Pathway Diagram
Tamoxifen Metabolism Pathway antibodies	Tamoxifen Metabolism Pathway Diagram

Diseases associated with SULT1A1 active protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>166 publications with SULT1A1 and Neoplasms
Breast Neoplasms Antibodies	>73 publications with SULT1A1 and Breast Neoplasms
Urologic Neoplasms Antibodies	>17 publications with SULT1A1 and Urologic Neoplasms
Lung Neoplasms Antibodies	>16 publications with SULT1A1 and Lung Neoplasms
Liver Neoplasms Antibodies	>16 publications with SULT1A1 and Liver Neoplasms
Liver Diseases Antibodies	>14 publications with SULT1A1 and Liver Diseases
Urinary Bladder Neoplasms Antibodies	>13 publications with SULT1A1 and Urinary Bladder Neoplasms
Carcinoma, Hepatocellular Antibodies	>8 publications with SULT1A1 and Carcinoma, Hepatocellular
Brain Diseases Antibodies	>7 publications with SULT1A1 and Brain Diseases
Prostatic Neoplasms Antibodies	>7 publications with SULT1A1 and Prostatic Neoplasms