Growth Hormone, Porcine (GHR) Active Protein

Function: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway.The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

Subunit structure: On growth hormone (GH) binding, forms homodimers and binds JAK2 via a box 1-containing domain

By similarity. Binding to SOCS3 inhibits JAK2 activation, binding to CIS and SOCS2 inhibits STAT5 activation

By similarity.

Subcellular location: Cell membrane; Single-pass type I membrane protein

By similarity. Note: On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway

By similarity.Growth hormone-binding protein: Secreted

By similarity. Note: Complexed to a substantial fraction of circulating GH

By similarity.

Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.The box 1 motif is required for JAK interaction and/or activation.The extracellular domain is the ligand-binding domain representing the growth hormone-binding protein (GHBP).The ubiquitination-dependent endocytosis motif (UbE) is required for recruitment of the ubiquitin conjugation system on to the receptor and for its internalization

By similarity.

Post-translational modification: On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2

By similarity. Ref.2On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization

By similarity.

Sequence similarities: Belongs to the type I cytokine receptor family. Type 1 subfamily.Contains 1 fibronectin type-III domain.