HMOX2 Recombinant Protein – Cat# MBS637916

Heme Oxygenase 2 (HMOX2) Recombinant Protein

Name: HMOX2 Recombinant Protein; Heme Oxygenase 2; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS637916
Price: 690 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS637916

Heme oxygenase-2 (HO-2) is the constitutive isoform of heme oxygenase which catalyzes the NADPH, O2 and cytochrome P450 reductase dependent oxidation of heme to carbonTo date, three heme oxygenase isoforms HO-1, HO-2 and HO-3 have been identified. HO-1 or… More details

$690 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Heme Oxygenase 2 (HMOX2), Recombinant Protein

Full Product Name

Heme Oxygenase 2, Recombinant, Human (HO-2, HMOX2)

Product Gene Name

HMOX2 recombinant protein

Form/Format

Supplied as a liquid in DPBS (8.1mM Na2PO4•7H2O, 1.5mM KH2PO4, 2.7mM potassium chloride, 137mM sodium chloride, pH 7.2) with 50uM EDTA in 10% glycerol.

Purity/Purification

Highly Purified
90% as determined by SDS-PAGE analysis.

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 12 months.

Molecular Weight

36,033 Da

Chromosome Location

Chromosome: 16; NC_000016.9 (4524719..4560348). Location: 16p13.3

OMIM

141251

3D Structure

ModBase 3D Structure for P30519

Product Categories/Family for HMOX2 recombinant protein

Molecular Biology; MB-Enzymes

Applications Tested/Suitable for HMOX2 recombinant protein

Western Blot (WB), Immunohistochemistry (IHC)

Application Notes for HMOX2 recombinant protein

Suitable for use in Western Blot and Immunohistochemistry (1:2,000).
Dilution: Western Blot: We recommend that the material be diluted in 1X sample buffer (e.g. Laemmli, U.K., (1970) Nature 277: 680-685). On a 15-well minigel system, 50ng of protein per lane should be sufficient when used in a Western Blot. This protein mixture yields a band of 34.4kD. An ~70kD band is also observed, which may be aggregates of HO-2.

Other Notes

Small volumes of HMOX2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HMOX2 purchase

MBS637916 is a recombinant protein targeting HMOX2. Also known as Heme Oxygenase 2, Recombinant, Human (HO-2, HMOX2).

Additional Details

NCBI/Uniprot data below describe general gene information for HMOX2. It may not necessarily be applicable to this product.

NCBI GI #

8051608

NCBI GeneID

3163

NCBI Accession #

NP_002125.3

UniProt Primary Accession #

P30519

UniProt Secondary Accession #

O60605; A8MT35; D3DUD5

UniProt Related Accession #

P30519

GenBank Nucleotide #

NM_002134.3

NCBI Official Full Name

heme oxygenase 2

NCBI Official Synonym Full Names

heme oxygenase (decycling) 2

NCBI Official Symbol

HMOX2

NCBI Official Synonym Symbols

HO-2

UniProt Protein Name

Heme oxygenase 2

Protein Family

Heme oxygenase

UniProt Gene Name

HMOX2

UniProt Synonym Gene Names

HO2; HO-2

UniProt Entry Name

HMOX2_HUMAN

NCBI Protein Information

heme oxygenase 2

NCBI Summary for HMOX2

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Alternative splice variants encoding the same protein have been identified at this locus. [provided by RefSeq, Jul 2008]

UniProt Comments for HMOX2

HMOX2: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter. Belongs to the heme oxygenase family.

Protein type: Oxidoreductase; EC 1.14.99.3; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: endoplasmic reticulum membrane; membrane; plasma membrane

Molecular Function: protein binding; metal ion binding; heme oxygenase (decyclizing) activity

Biological Process: heme catabolic process; cellular iron ion homeostasis; porphyrin metabolic process; response to hypoxia; heme oxidation; transmembrane transport

Research Articles on HMOX2

1. increased expression of nucleated RBC, HSP90alpha and corresponding decreased expression of HO-2 in such hypoxic condition may play a protective role; to prevent cord blood RBC against stress induced damage during preeclampsia.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with HMOX2 recombinant protein

Reference Product	PubMed Publications
BLVRA recombinant protein	>1 publications with HMOX2 and BLVRA

Pathways associated with HMOX2 recombinant protein

Products by Pathway	Pathway Diagram
Heme Degradation Pathway antibodies	Heme Degradation Pathway Diagram
Iron Uptake And Transport Pathway antibodies	Iron Uptake And Transport Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Porphyrins Pathway antibodies	Metabolism Of Porphyrins Pathway Diagram
Mineral Absorption Pathway antibodies	Mineral Absorption Pathway Diagram
Mineral Absorption Pathway antibodies	Mineral Absorption Pathway Diagram
Porphyrin And Chlorophyll Metabolism Pathway antibodies	Porphyrin And Chlorophyll Metabolism Pathway Diagram
Porphyrin And Chlorophyll Metabolism Pathway antibodies	Porphyrin And Chlorophyll Metabolism Pathway Diagram
Transmembrane Transport Of Small Molecules Pathway antibodies	Transmembrane Transport Of Small Molecules Pathway Diagram
Heme Degradation Pathway antibodies	Heme Degradation Pathway Diagram

Diseases associated with HMOX2 recombinant protein

Disease Name	Pubmed Publications
Brain Diseases Antibodies	>2 publications with HMOX2 and Brain Diseases
Nervous System Diseases Antibodies	>2 publications with HMOX2 and Nervous System Diseases
Inflammation Antibodies	>2 publications with HMOX2 and Inflammation
Pain Antibodies	>1 publications with HMOX2 and Pain
Seizures Antibodies	>1 publications with HMOX2 and Seizures
Cardiovascular Diseases Antibodies	>1 publications with HMOX2 and Cardiovascular Diseases
Hypertension Antibodies	>1 publications with HMOX2 and Hypertension
Fatty Liver Antibodies	>1 publications with HMOX2 and Fatty Liver
Necrosis Antibodies	>1 publications with HMOX2 and Necrosis

Organs/Tissues associated with HMOX2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>3 publications with HMOX2 and Liver
Blood Antibodies	>2 publications with HMOX2 and Blood
Ear Antibodies	>1 publications with HMOX2 and Ear
Muscle Antibodies	>1 publications with HMOX2 and Muscle
Eye Antibodies	>1 publications with HMOX2 and Eye
Skin Antibodies	>1 publications with HMOX2 and Skin
Testis Antibodies	>1 publications with HMOX2 and Testis
Brain Antibodies	>1 publications with HMOX2 and Brain