Tissue Inhibitor of Metalloproteinases 1, Western Blot Control Recombinant Protein

TIMP-1 is the first described and best characterized of the four known mammalian TIMPs. The TIMPs are so named because they are slow, tight binding endogenous inhibitors of the Matrix Metalloproteinases (MMPs). The four TIMPs have different inhibition constants for the different MMPs studied. TIMP-2 has a greater efficiency against MMP-2, and TIMP-1 works better against MMP-9, MMP-1 and MMP-3. The function of the ADAMs (A Disintigrin And Metalloproteinase) proteinases is getting more attention, and it has been shown that TIMP-3 is an efficient "sheddase" inhibitor, inhibiting ADAM-17 (TACE) at the low nanomolar levels seen with MMP inhibition. The other ADAMs proteinases have not yet been assayed for TIMP inhibition, but TIMP-1 seems to be much less active on ADAM-17 than is TIMP-3. The TIMP-1 is largely the glycosylated form, about 29kD in size on reduced Western Blots.

T5580-06B is recombinant mouse tissue inhibitor of metalloproteinases-1 (rmTIMP-1) with a histidine tag.

Small volumes of Tissue Inhibitor of Metalloproteinases 1, Western Blot Control recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS638014 is a recombinant protein targeting Tissue Inhibitor of Metalloproteinases 1, Western Blot Control. Also known as Tissue Inhibitor of Metalloproteinases 1, Recombinant, Mouse, Western Blot Control (TIMP1, Erythroid Potentiating Activity, EPA, Collagenase Inhibitor, CI).