Hepatitis C Virus NS5, Genotype 6a Recombinant Protein

The hepatitis C virus (HCV) NS5A gene product is a phosphorylated 56- to 58kD nonstructural protein that displays a multitude of activities related to enhancement of viral pathogenesis. Although associated with other viral encoded proteins as part of the viral replicase complex positioned on the cytoplasmic side of the endoplasmic reticulum, a role for NS5A in viral replication has not been defined. Truncated versions of NS5A can act as transcriptional activators, while other recently characterized interactions of NS5A with cellular proteins indicate its pleiotropic role in HCV-host interactions.

It has been shown that NS5B is a membrane-associated protein, which contains a C-terminal domain comprising í21 hydrophobic amino acids that is responsible for membrane anchorage. NS5B may form a complex with cellular proteins or other HCV nonstructural proteins, including NS3, the viral protease and helicase; NS4A, a cofactor of NS3 protease activity; and NS5A, a phosphoprotein containing a putative interferon sensitivity region. Although the HCV replication mechanism is not clearly understood, the essential role of NS5B polymerase in the HCV replication and infection process has been demonstrated in chimpanzees. Accordingly, it has been viewed as an attractive target for antiviral intervention.
The protein contains the HCV NS5 Genotype 1 immunodominant regions, amino acids 2212-2313.

Small volumes of Hepatitis C Virus NS5, Genotype 6a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS638076 is a recombinant protein targeting Hepatitis C Virus NS5, Genotype 6a. Also known as Hepatitis C Virus NS5, Genotype 6a, Recombinant (HCV). Host: E Coli.