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PRL-3 Human (PTP4A3) Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS638093

Protein tyrosine phosphatase type IVA 3 (PRL-3), as known as PTP4A3, belongs to a small class of prenylated protein tyrosine phosphatases (PTPs) that remove phosphate modifications from tyrosine residues on proteins. This protein enhances cell proliferation,… More details

$580 / 0.1 mg +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PRL-3 Human (PTP4A3), Recombinant Protein
Full Product Name
PRL-3, Recombinant Human (Protein tyrosine phosphatase type IVA 3)
Sequence
MGSSHHHHHH SSGLVPRGSH MARMNRPAPV EVSYKHMRFL ITHNPTNATL STFIEDLKKY GATTVVRVCE VTYDKTPLEK DGITVVDWPF DDGAPPPGKV VEDWLSLVKA KFCEAPGSCV AVHCVAGLGR APVLVALALI ESGMKYEDAI QFIRQKRRGA INSKQLTYLE KYRPKQRLRF
KDPHTH KTRC CVM
Form/Format
Supplied as liquid in 20 mM Tris-HCl buffer, pH8.0, 2 mM EDTA, 1 mM DTT, 10% glycerol
Purity/Purification
Affinity Purified
~95% by SDS-PAGE Purified by immunoaffinity chromatography.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
21.6kD
Chromosome Location
Chromosome: 8; NC_000008.10 (142402093..142442554). Location: 8q24.3
OMIM
606449
3D Structure
ModBase 3D Structure for O75365
Application Notes for PTP4A3 recombinant protein
Suitable for use in ELISA and Western Blot.

SDS-Page of PTP4A3 recombinant protein

15% SDS-PAGE (3ug)
PTP4A3 Recombinant Protein – Cat# MBS638093

Other Notes

Small volumes of PTP4A3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PTP4A3 purchase

MBS638093 is a recombinant protein targeting PTP4A3. Also known as PRL-3, Recombinant Human (Protein tyrosine phosphatase type IVA 3).

Additional Details

NCBI/Uniprot data below describe general gene information for PTP4A3. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
protein tyrosine phosphatase type IVA 3 isoform 1
NCBI Official Synonym Full Names
protein tyrosine phosphatase type IVA, member 3
NCBI Official Symbol
PTP4A3
NCBI Official Synonym Symbols
PRL3; PRL-3; PRL-R
UniProt Protein Name
Protein tyrosine phosphatase type IVA 3
UniProt Synonym Protein Names
PRL-R; Protein-tyrosine phosphatase 4a3; Protein-tyrosine phosphatase of regenerating liver 3
UniProt Gene Name
PTP4A3
UniProt Synonym Gene Names
PRL3; PRL-3
UniProt Entry Name
TP4A3_HUMAN
NCBI Protein Information
protein tyrosine phosphatase type IVA 3; protein-tyrosine phosphatase 4a3; potentially prenylated protein tyrosine phosphatase; protein-tyrosine phosphatase of regenerating liver 3

NCBI Summary for PTP4A3

This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
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UniProt Comments for PTP4A3

PTP4A3: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. Belongs to the protein-tyrosine phosphatase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor)

Chromosomal Location of Human Ortholog: 8q24.3

Cellular Component: early endosome; plasma membrane

Molecular Function: prenylated protein tyrosine phosphatase activity

Biological Process: endothelial cell migration
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PTP4A3 recombinant protein

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