ANXA2 Recombinant Protein – Cat# MBS638184

15% SDS-PAGE using A2295-15B2 (3ug).

Annexin A2 (ANXA2) Recombinant Protein

Name: ANXA2 Recombinant Protein; Annexin A2; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS638184
Price: 465 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS638184

Annexin A2 belongs to a family of calcium-dependent membrane and phospholipid binding proteins. It plays a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast… More details

$465 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Annexin A2 (ANXA2), Recombinant Protein

Full Product Name

Annexin A2, Recombinant, Human

Product Gene Name

ANXA2 recombinant protein

Sequence

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMST VHEILCKLSL EGDHSTPPSA YGSVKAYTNF DAERDALNIE TAIKTKGVDE VTIVNILTNR SNAQRQDIAF AYQRRTKKEL ASALKSALSG HLETVILGLL KTPAQYDASE LKASMKGLGT DEDSLIEIIC SRTNQELQEI NRVYKEMYKT DLEKDIISDT SGDFRKLMVA LAKGRRAEDG SVIDYELIDQ DARDLYDAGV KRKGTDVPKW ISIMTERSVP HLQKVFDRYK SYSPYDMLES IRKEVKGDLE NAFLNLVQCI QNKPLYFADR LYDSMKGKGT RDKVLIRIMV SRSEVDMLKI RSEFKRKYGK SLYYYIQQDT KGDYQKALLY LCGGDD

Host

E Coli

Form/Format

Supplied as a liquid in 20mM Tris-HCl buffer, pH8.0, 10% glycerol, 0.1M sodium chloride

Purity/Purification

Affinity Purified
~95% by SDS-PAGE Concentration: ~0.5mg/ml

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

42.8kD

Chromosome Location

Chromosome: 1; NC_010443.4 (123368568..123414399). Location: chromosome: 1

3D Structure

ModBase 3D Structure for P19620

Product Categories/Family for ANXA2 recombinant protein

Molecular Biology; MB-Annexin

Applications Tested/Suitable for ANXA2 recombinant protein

Western Blot (WB)

Application Notes for ANXA2 recombinant protein

Suitable for use in Western Blot.

Other Notes

Small volumes of ANXA2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ANXA2 purchase

MBS638184 is a recombinant protein targeting ANXA2. Also known as Annexin A2, Recombinant, Human. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for ANXA2. It may not necessarily be applicable to this product.

NCBI GI #

54020966

NCBI GeneID

406192

NCBI Accession #

NP_001005726.1

UniProt Primary Accession #

P19620

UniProt Secondary Accession #

Q5Y2C7

UniProt Related Accession #

P19620

GenBank Nucleotide #

NM_001005726.1

NCBI Official Full Name

annexin A2

NCBI Official Symbol

ANXA2

UniProt Protein Name

Annexin A2

UniProt Synonym Protein Names

Annexin II; Annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; Placental anticoagulant protein IV; PAP-IV; Protein I; p36

Protein Family

Annexin

UniProt Gene Name

ANXA2

UniProt Synonym Gene Names

ANX2; PAP-IV

UniProt Entry Name

ANXA2_PIG

NCBI Protein Information

annexin A2; p36; PAP-IV; annexin-2; protein I; annexin II; lipocortin II; chromobindin-8; calpactin I heavy chain; calpactin-1 heavy chain; placental anticoagulant protein IV

UniProt Comments for ANXA2

Function: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.

Subunit structure: Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1 and DYSF

By similarity. Interacts with COCH

By similarity.

Subcellular location: Secreted › extracellular space › extracellular matrix › basement membrane. Melanosome

By similarity. Note: In the lamina beneath the plasma membrane.

Domain: A pair of annexin repeats may form one binding site for calcium and phospholipid.

Post-translational modification: ISGylated

By similarity.

Miscellaneous: It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.

Sequence similarities: Belongs to the annexin family.Contains 4 annexin repeats.

Research Articles on ANXA2

1. An octameric model is proposed for the annexin A2/p11(S100A10) complex, which exerts annexin A2 function. The proposed structure of the annexin A2/p11 octamer sheds new light into annexin A2/p11 interaction.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ANXA2 recombinant protein

Reference Product	PubMed Publications
S100A10 recombinant protein	>30 publications with ANXA2 and S100A10
ANXA1 recombinant protein	>14 publications with ANXA2 and ANXA1
ANXA5 recombinant protein	>7 publications with ANXA2 and ANXA5
VIM recombinant protein	>4 publications with ANXA2 and VIM
S100A11 recombinant protein	>2 publications with ANXA2 and S100A11

Diseases associated with ANXA2 recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>78 publications with ANXA2 and Neoplasms
Adenocarcinoma Antibodies	>20 publications with ANXA2 and Adenocarcinoma
Inflammation Antibodies	>17 publications with ANXA2 and Inflammation
Neoplasm Metastasis Antibodies	>16 publications with ANXA2 and Neoplasm Metastasis
Cardiovascular Diseases Antibodies	>15 publications with ANXA2 and Cardiovascular Diseases
Neoplasm Invasiveness Antibodies	>14 publications with ANXA2 and Neoplasm Invasiveness
Carcinoma, Hepatocellular Antibodies	>14 publications with ANXA2 and Carcinoma, Hepatocellular
Liver Diseases Antibodies	>14 publications with ANXA2 and Liver Diseases
Disease Models, Animal Antibodies	>13 publications with ANXA2 and Disease Models, Animal
Necrosis Antibodies	>12 publications with ANXA2 and Necrosis

Organs/Tissues associated with ANXA2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>49 publications with ANXA2 and Blood
Liver Antibodies	>23 publications with ANXA2 and Liver
Lung Antibodies	>16 publications with ANXA2 and Lung
Brain Antibodies	>13 publications with ANXA2 and Brain
Muscle Antibodies	>11 publications with ANXA2 and Muscle
Bone Marrow Antibodies	>10 publications with ANXA2 and Bone Marrow
Prostate Antibodies	>9 publications with ANXA2 and Prostate
Skin Antibodies	>7 publications with ANXA2 and Skin
Intestine Antibodies	>7 publications with ANXA2 and Intestine
Embryonic Tissue Antibodies	>7 publications with ANXA2 and Embryonic Tissue