JUP Antibody – Rabbit Polyclonal

CTNNG: Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. Homodimer. Component of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma- catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Interacts with MUC1. Interacts with CAV1. Interacts with PTPRJ. Interacts with DSC2. Belongs to the beta-catenin family.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: desmosome; internal side of plasma membrane; focal adhesion; apicolateral plasma membrane; intermediate filament; fascia adherens; intercellular junction; zonula adherens; catenin complex; cytosol; Z disc; actin cytoskeleton; cytoskeleton; cell-cell adherens junction; hemidesmosome; cytoplasm; plasma membrane; nucleus; lateral plasma membrane

Molecular Function: protein binding; signal transducer activity; protein homodimerization activity; structural constituent of cell wall; cadherin binding; transcription coactivator activity; structural molecule activity; protein kinase binding; protein phosphatase binding; alpha-catenin binding; nuclear hormone receptor binding

Biological Process: skin development; intercellular junction assembly and maintenance; cell migration; protein heterooligomerization; cytoskeletal anchoring; detection of mechanical stimulus; regulation of cell proliferation; cell-cell adhesion; positive regulation of protein import into nucleus; regulation of cell fate specification; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; vascular endothelial growth factor receptor signaling pathway

Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 12; Naxos Disease