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ESRP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS641278

mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that… More details

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Product Overview

Online Datasheet in PDF
Product Name
ESRP1, Polyclonal Antibody
Full Product Name
ESRP1, NT (ESRP1, RBM35A, Epithelial splicing regulatory protein 1, RNA-binding motif protein 35A, RNA-binding protein 35A)
Product Gene Name
anti-ESRP1 antibody
Product Synonym Names
Anti -ESRP1, NT (ESRP1, RBM35A, Epithelial splicing regulatory protein 1, RNA-binding motif protein 35A, RNA-binding protein 35A)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
75,585 Da
Chromosome Location
Chromosome: 8; NC_000008.10 (95653364..95719694). Location: 8q22.1
OMIM
612959
3D Structure
ModBase 3D Structure for Q6NXG1
Immunogen
ESRP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 189-219 amino acids from the N-terminal region of human ESRP1.

Product Categories/Family for anti-ESRP1 antibody

Antibodies; Abs to RNA Binding Proteins
Applications Tested/Suitable for anti-ESRP1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ESRP1 antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100

Western Blot (WB) of anti-ESRP1 antibody

ESRP1 Antibody (N-term) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the ESRP1 antibody detected the ESRP1 protein (arrow).
Rabbit Anti-ESRP1 Polyclonal Antibody – Cat# MBS641278

Immunohistochemistry (IHC) of anti-ESRP1 antibody

ESRP1 antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ESRP1 antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-ESRP1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS641278

Other Notes

Small volumes of anti-ESRP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ESRP1 purchase

MBS641278 is an antibody targeting ESRP1. Also known as ESRP1, NT (ESRP1, RBM35A, Epithelial splicing regulatory protein 1, RNA-binding motif protein 35A, RNA-binding protein 35A). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ESRP1. It may not necessarily be applicable to this product.

NCBI GI #
170763533
NCBI GeneID
54845
NCBI Accession #
NP_001116299.1
UniProt Primary Accession #
Q6NXG1
UniProt Secondary Accession #
Q2M2B0; Q499G3; Q6PJ86; Q9NXL8; A6NHA8; A8MPX1; E9PB47
UniProt Related Accession #
Q6NXG1
GenBank Nucleotide #
NM_001122827.1
NCBI Official Full Name
epithelial splicing regulatory protein 1 isoform 5
NCBI Official Synonym Full Names
epithelial splicing regulatory protein 1
NCBI Official Symbol
ESRP1
NCBI Official Synonym Symbols
RBM35A; RMB35A
UniProt Protein Name
Epithelial splicing regulatory protein 1
UniProt Synonym Protein Names
RNA-binding motif protein 35A; RNA-binding protein 35A
Protein Family
Epithelial splicing regulatory protein
UniProt Gene Name
ESRP1
UniProt Synonym Gene Names
RBM35A
UniProt Entry Name
ESRP1_HUMAN
NCBI Protein Information
epithelial splicing regulatory protein 1; RNA-binding protein 35A; RNA binding motif protein 35A; RNA-binding motif protein 35A

NCBI Summary for ESRP1

ESPR1 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009]

UniProt Comments for ESRP1

RBM35A: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. Belongs to the ESRP family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA processing

Chromosomal Location of Human Ortholog: 8q22.1

Cellular Component: nucleus

Molecular Function: mRNA binding; nucleotide binding

Biological Process: regulation of RNA splicing; RNA splicing; mRNA processing
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Research Articles on ESRP1

1. ESRP1 and PNN modulate alternative splicing of a specific subset of target genes, but not general splicing events, in HCET cells to maintain or enhance epithelial characteristics.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ESRP1 antibody

 Reference Product  PubMed Publications
 CD44 antibody  >5 publications with ESRP1 and CD44
 FGFR2 antibody  >5 publications with ESRP1 and FGFR2
 ENAH antibody  >3 publications with ESRP1 and ENAH
 CTNND1 antibody  >2 publications with ESRP1 and CTNND1
 GRHL2 antibody  >1 publications with ESRP1 and GRHL2

Diseases associated with anti-ESRP1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >12 publications with ESRP1 and Neoplasms
 Breast Neoplasms Antibodies  >7 publications with ESRP1 and Breast Neoplasms
 Melanoma Antibodies  >2 publications with ESRP1 and Melanoma
 Respiratory Tract Diseases Antibodies  >2 publications with ESRP1 and Respiratory Tract Diseases
 Neoplasms, Experimental Antibodies  >1 publications with ESRP1 and Neoplasms, Experimental
 Gastrointestinal Diseases Antibodies  >1 publications with ESRP1 and Gastrointestinal Diseases
 Prostatic Neoplasms Antibodies  >1 publications with ESRP1 and Prostatic Neoplasms

Organs/Tissues associated with anti-ESRP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >3 publications with ESRP1 and Lung
 Placenta Antibodies  >2 publications with ESRP1 and Placenta
 Embryonic Tissue Antibodies  >2 publications with ESRP1 and Embryonic Tissue
 Prostate Antibodies  >2 publications with ESRP1 and Prostate
 Stomach Antibodies  >1 publications with ESRP1 and Stomach
 Liver Antibodies  >1 publications with ESRP1 and Liver
 Uterus Antibodies  >1 publications with ESRP1 and Uterus
 Mammary Gland Antibodies  >1 publications with ESRP1 and Mammary Gland
 Skin Antibodies  >1 publications with ESRP1 and Skin
 Pituitary Gland Antibodies  >1 publications with ESRP1 and Pituitary Gland
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