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PPARA Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS641282

Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PPARA, Polyclonal Antibody
Full Product Name
PPARA, ID (PPARA, NR1C1, PPAR, Peroxisome proliferator-activated receptor alpha, Nuclear receptor subfamily 1 group C member 1)
Product Gene Name
anti-PPARA antibody
Product Synonym Names
Anti -PPARA, ID (PPARA, NR1C1, PPAR, Peroxisome proliferator-activated receptor alpha, Nuclear receptor subfamily 1 group C member 1)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Concentration
0.35 mg/ml (lot specific)
Specificity
Mouse
Preparation and Storage
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Chromosome Location
Chromosome: 22; NC_000022.10 (46546458..46639653). Location: 22q13.31
OMIM
170998
3D Structure
ModBase 3D Structure for Q07869
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 153-181 in the central region of human PPARA. Species Sequence Homology: Rat and Xenopus

Product Categories/Family for anti-PPARA antibody

Antibodies; Abs to Obesity Proteins
Applications Tested/Suitable for anti-PPARA antibody
ELISA (EIA), Western Blot (WB), Flow Cytometry (FC)
Application Notes for anti-PPARA antibody
WB: 1:1000
Indirect FC: 1:10-50
Optimal dilutions should be determined by the researcher.

Western Blot (WB) of anti-PPARA antibody

PPARA Antibody (Center) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the PPARA antibody detected the PPARA protein (arrow).
Rabbit Anti-PPARA Polyclonal Antibody – Cat# MBS641282

Other Notes

Small volumes of anti-PPARA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PPARA purchase

MBS641282 is an antibody targeting PPARA. Also known as PPARA, ID (PPARA, NR1C1, PPAR, Peroxisome proliferator-activated receptor alpha, Nuclear receptor subfamily 1 group C member 1). Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PPARA. It may not necessarily be applicable to this product.

NCBI GI #
50348666
NCBI GeneID
5465
NCBI Accession #
NP_001001928
UniProt Primary Accession #
Q07869
UniProt Secondary Accession #
Q16241; Q6I9S0; Q92486; Q92689; Q9Y3N1; B0G0X3
UniProt Related Accession #
Q07869
GenBank Nucleotide #
NM_001001928.2
NCBI Official Full Name
peroxisome proliferator-activated receptor alpha
NCBI Official Synonym Full Names
peroxisome proliferator-activated receptor alpha
NCBI Official Symbol
PPARA
NCBI Official Synonym Symbols
PPAR; NR1C1; hPPAR; PPARalpha
UniProt Protein Name
Peroxisome proliferator-activated receptor alpha
UniProt Synonym Protein Names
Nuclear receptor subfamily 1 group C member 1
Protein Family
Peroxisome proliferator-activated receptor
UniProt Gene Name
PPARA
UniProt Synonym Gene Names
NR1C1; PPAR; PPAR-alpha
UniProt Entry Name
PPARA_HUMAN
NCBI Protein Information
peroxisome proliferator-activated receptor alpha; PPAR-alpha; nuclear receptor subfamily 1 group C member 1; peroxisome proliferative activated receptor, alpha; peroxisome proliferator-activated nuclear receptor alpha variant 3

UniProt Comments for PPARA

PPAR-alpha: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. Belongs to the nuclear hormone receptor family. NR1 subfamily.

Protein type: Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 22q13.31

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein domain specific binding; ligand-dependent nuclear receptor activity; NFAT protein binding; zinc ion binding; drug binding; phosphatase binding; protein binding; DNA binding; ubiquitin conjugating enzyme binding; sequence-specific DNA binding; protein complex binding; steroid hormone receptor activity; lipid binding; transcription factor activity

Biological Process: circadian rhythm; epidermis development; wound healing; positive regulation of transcription, DNA-dependent; heart development; behavioral response to nicotine; negative regulation of transcription from RNA polymerase II promoter; cellular lipid metabolic process; fatty acid metabolic process; negative regulation of appetite; response to insulin stimulus; positive regulation of gluconeogenesis; negative regulation of blood pressure; circadian regulation of gene expression; negative regulation of glycolysis; negative regulation of protein binding; transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; lipoprotein metabolic process; regulation of circadian rhythm; positive regulation of fatty acid beta-oxidation; positive regulation of fatty acid oxidation; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; gene expression; lipid metabolic process; fatty acid transport
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Research Articles on PPARA

1. Homozygous genotype (CC) of rs4253778 increased the risk of essential hypertension. The A-G-V and C-G-V haplotypes were associated with a statistically significant decreased risk of EH.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PPARA antibody

 Reference Product  PubMed Publications
 RXRA antibody  >8 publications with PPARA and RXRA
 ABCA1 antibody  >7 publications with PPARA and ABCA1
 APOA5 antibody  >3 publications with PPARA and APOA5
 HIF1A antibody  >1 publications with PPARA and HIF1A
 PLIN2 antibody  >1 publications with PPARA and PLIN2
 NCOA1 antibody  >1 publications with PPARA and NCOA1

Pathways associated with anti-PPARA antibody

 Products by Pathway  Pathway Diagram
 Activation Of Gene Expression By SREBP (SREBF) Pathway antibodies  Activation Of Gene Expression By SREBP (SREBF) Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 BMAL1:CLOCK/NPAS2 Activates Circadian Expression Pathway antibodies  BMAL1:CLOCK/NPAS2 Activates Circadian Expression Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 Circadian Repression Of Expression By REV-ERBA Pathway antibodies  Circadian Repression Of Expression By REV-ERBA Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Energy Metabolism Pathway antibodies  Energy Metabolism Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram

Diseases associated with anti-PPARA antibody

 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >43 publications with PPARA and Fatty Liver
 Cardiovascular Diseases Antibodies  >40 publications with PPARA and Cardiovascular Diseases
 Liver Diseases Antibodies  >33 publications with PPARA and Liver Diseases
 Inflammation Antibodies  >26 publications with PPARA and Inflammation
 Obesity Antibodies  >25 publications with PPARA and Obesity
 Heart Diseases Antibodies  >23 publications with PPARA and Heart Diseases
 Insulin Resistance Antibodies  >20 publications with PPARA and Insulin Resistance
 Atherosclerosis Antibodies  >16 publications with PPARA and Atherosclerosis
 Dyslipidemias Antibodies  >14 publications with PPARA and Dyslipidemias
 Diabetes Mellitus, Type 2 Antibodies  >12 publications with PPARA and Diabetes Mellitus, Type 2

Organs/Tissues associated with anti-PPARA antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >22 publications with PPARA and Heart
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