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ARHGAP17 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS641384

RICH1 is a GTPase-activating protein (GAP). GAPs stimulate the intrinsic GTP hydrolysis of small G proteins, such as RHOA (MIM 165390), RAC1 (MIM 602048), and CDC42 (MIM 116952).[supplied by OMIM]. More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
ARHGAP17, Polyclonal Antibody
Full Product Name
ARHGAP17, NT (ARHGAP17, RICH1, Rho GTPase-activating protein 17, Rho-type GTPase-activating protein 17, RhoGAP interacting with CIP4 homologs protein 1)
Product Gene Name
anti-ARHGAP17 antibody
Product Synonym Names
Anti -ARHGAP17, NT (ARHGAP17, RICH1, Rho GTPase-activating protein 17, Rho-type GTPase-activating protein 17, RhoGAP interacting with CIP4 homologs protein 1)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
95,437 Da
Chromosome Location
Chromosome: 16; NC_000016.9 (24930710..25026695, complement). Location: 16p12.1
OMIM
608293
3D Structure
ModBase 3D Structure for Q68EM7
Immunogen
ARHGAP17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-74 amino acids from the N-terminal region of human ARHGAP17.

Product Categories/Family for anti-ARHGAP17 antibody

Antibodies; Abs to GTPase; Rab; Ras; Rho Proteins
Applications Tested/Suitable for anti-ARHGAP17 antibody
ELISA (EL/EIA), Western Blot (WB), Flow Cytometry (FC/FACS)
Application Notes for anti-ARHGAP17 antibody
Suitable for use in Western Blot, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Flow Cytometry: 1:10-50

Western Blot (WB) of anti-ARHGAP17 antibody

ARHGAP17 Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the ARHGAP17 antibody detected the ARHGAP17 protein (arrow).
Rabbit Anti-ARHGAP17 Polyclonal Antibody – Cat# MBS641384

Flow Cytometry (FC/FACS) of anti-ARHGAP17 antibody

ARHGAP17 Antibody (N-term) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-ARHGAP17 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS641384

Other Notes

Small volumes of anti-ARHGAP17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ARHGAP17 purchase

MBS641384 is an antibody targeting ARHGAP17. Also known as ARHGAP17, NT (ARHGAP17, RICH1, Rho GTPase-activating protein 17, Rho-type GTPase-activating protein 17, RhoGAP interacting with CIP4 homologs protein 1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ARHGAP17. It may not necessarily be applicable to this product.

NCBI GI #
12654797
NCBI GeneID
55114
NCBI Accession #
AAH01241.1
UniProt Primary Accession #
Q68EM7
UniProt Secondary Accession #
Q6ZUS4; Q7Z2F2; Q8NDG2; Q96KS2; Q96KS3; Q96SS8; Q9BVF6; Q9H8U5; Q9NW54; A8K6M6
UniProt Related Accession #
Q68EM7
NCBI Official Full Name
ARHGAP17 protein
NCBI Official Synonym Full Names
Rho GTPase activating protein 17
NCBI Official Symbol
ARHGAP17
NCBI Official Synonym Symbols
PP367; RICH1; WBP15; MST066; MST110; NADRIN; PP4534; RICH1B; MSTP038; MSTP066; MSTP110
UniProt Protein Name
Rho GTPase-activating protein 17
UniProt Synonym Protein Names
Rho-type GTPase-activating protein 17; RhoGAP interacting with CIP4 homologs protein 1
Protein Family
Rho GTPase-activating protein
UniProt Gene Name
ARHGAP17
UniProt Synonym Gene Names
RICH1; RICH-1
UniProt Entry Name
RHG17_HUMAN
NCBI Protein Information
rho GTPase-activating protein 17; RICH-1; rho-type GTPase-activating protein 17; RhoGAP interacting with CIP4 homologs 1; rhoGAP interacting with CIP4 homologs protein 1; neuron-associated developmentally regulated protein

NCBI Summary for ARHGAP17

RICH1 is a GTPase-activating protein (GAP). GAPs stimulate the intrinsic GTP hydrolysis of small G proteins, such as RHOA (MIM 165390), RAC1 (MIM 602048), and CDC42 (MIM 116952).[supplied by OMIM, Apr 2004]

UniProt Comments for ARHGAP17

ARHGAP17: Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activitor in vitro for RAC1. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs; GAPs, Rac/Rho

Chromosomal Location of Human Ortholog: 16p12.1

Cellular Component: tight junction; plasma membrane; cytosol

Molecular Function: protein binding; SH3 domain binding; GTPase activator activity

Biological Process: regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; positive regulation of GTPase activity
Show more

Research Articles on ARHGAP17

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ARHGAP17 antibody

 Products by Pathway  Pathway Diagram
 Regulation Of CDC42 Activity Pathway antibodies  Regulation Of CDC42 Activity Pathway Diagram
 Regulation Of RAC1 Activity Pathway antibodies  Regulation Of RAC1 Activity Pathway Diagram
 Rho GTPase Cycle Pathway antibodies  Rho GTPase Cycle Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Rho GTPases Pathway antibodies  Signaling By Rho GTPases Pathway Diagram

Diseases associated with anti-ARHGAP17 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1 publications with ARHGAP17 and Neoplasms

Organs/Tissues associated with anti-ARHGAP17 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with ARHGAP17 and Brain
 Nerve Antibodies  >3 publications with ARHGAP17 and Nerve
 Embryonic Tissue Antibodies  >2 publications with ARHGAP17 and Embryonic Tissue
 Blood Antibodies  >1 publications with ARHGAP17 and Blood
 Spleen Antibodies  >1 publications with ARHGAP17 and Spleen
 Kidney Antibodies  >1 publications with ARHGAP17 and Kidney
 Lung Antibodies  >1 publications with ARHGAP17 and Lung
 Placenta Antibodies  >1 publications with ARHGAP17 and Placenta
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