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DUSP1 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS641390

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has… More details

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Product Overview

Online Datasheet in PDF
Product Name
DUSP1, Polyclonal Antibody
Full Product Name
DUSP1, CT (Dual Specificity Protein Phosphatase 1, CL100, Dual Specificity Protein Phosphatase hVH1, HVH1, Mitogen-activated Protein Kinase Phosphatase 1, MAP Kinase Phosphatase 1, MKP1, MKP-1, Protein-tyrosine Phosphatase CL100, PTPN10, VH1)
Product Gene Name
anti-DUSP1 antibody
Product Synonym Names
Anti -DUSP1, CT (Dual Specificity Protein Phosphatase 1, CL100, Dual Specificity Protein Phosphatase hVH1, HVH1, Mitogen-activated Protein Kinase Phosphatase 1, MAP Kinase Phosphatase 1, MKP1, MKP-1, Protein-tyrosine Phosphatase CL100, PTPN10, VH1)
Clonality
Polyclonal
Host
Goat
Species Reactivity
Human
Form/Format
Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human DUSP1. Species sequence homology: mouse and rat
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
39,298 Da
Chromosome Location
Chromosome: 5; NC_000005.9 (172195093..172198203, complement). Location: 5q34
OMIM
600714
3D Structure
ModBase 3D Structure for P28562
Immunogen
Synthetic peptide corresponding to SYLQSPITTSPSC from the C-terminal of human DUSP1.

Product Categories/Family for anti-DUSP1 antibody

Antibodies; Abs to Enzymes; Phosphatase
Applications Tested/Suitable for anti-DUSP1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-DUSP1 antibody
Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: ELISA: 1:32,000
Western Blot: 0.3-1ug/ml
Immunohistochemistry (Formalin-fixed, paraffin-embedded): 3.75ug/ml

Immunohistochemistry (IHC) of anti-DUSP1 antibody

Human Prostate (formalin-fixed, paraffin-embedded) stained with DUSP1 antibody at 3.75ug/ml followed by biotinylated goat IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.
Goat Anti-DUSP1 Polyclonal Antibody – Cat# MBS641390

Chemiluminescence of anti-DUSP1 antibody

Antibody (0.3ug/ml) staining of HeLa lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-DUSP1 Polyclonal Antibody, Chemiluminescence – Cat# MBS641390

Other Notes

Small volumes of anti-DUSP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DUSP1 purchase

MBS641390 is an antibody targeting DUSP1. Also known as DUSP1, CT (Dual Specificity Protein Phosphatase 1, CL100, Dual Specificity Protein Phosphatase hVH1, HVH1, Mitogen-activated Protein Kinase Phosphatase 1, MAP Kinase Phosphatase 1, MKP1, MKP-1, Protein-tyrosine Phosphatase CL100, PTPN10, VH1). Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for DUSP1. It may not necessarily be applicable to this product.

NCBI GI #
4758204
NCBI GeneID
1843
NCBI Accession #
NP_004408.1
UniProt Primary Accession #
P28562
UniProt Secondary Accession #
Q2V508; D3DQL9
UniProt Related Accession #
P28562
GenBank Nucleotide #
NM_004417.3
NCBI Official Full Name
dual specificity protein phosphatase 1
NCBI Official Synonym Full Names
dual specificity phosphatase 1
NCBI Official Symbol
DUSP1
NCBI Official Synonym Symbols
HVH1; MKP1; CL100; MKP-1; PTPN10
UniProt Protein Name
Dual specificity protein phosphatase 1
UniProt Synonym Protein Names
Dual specificity protein phosphatase hVH1; Mitogen-activated protein kinase phosphatase 1; MAP kinase phosphatase 1; MKP-1; Protein-tyrosine phosphatase CL100
Protein Family
Dual specificity protein phosphatase
UniProt Gene Name
DUSP1
UniProt Synonym Gene Names
CL100; MKP1; PTPN10; VH1; MAP kinase phosphatase 1; MKP-1
UniProt Entry Name
DUS1_HUMAN
NCBI Protein Information
dual specificity protein phosphatase 1; MAP kinase phosphatase 1; protein-tyrosine phosphatase CL100; dual specificity protein phosphatase hVH1; serine/threonine specific protein phosphatase; mitogen-activated protein kinase phosphatase 1

UniProt Comments for DUSP1

MKP-1: a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP1 specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation. It is induced in human skin fibroblasts by oxidative/heat stress and growth factors. Contains 1 rhodanese domain.

Protein type: Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, dual-specificity; EC 3.1.3.16

Chromosomal Location of Human Ortholog: 5q34

Cellular Component: cytoplasm; nucleus

Molecular Function: protein tyrosine/threonine phosphatase activity; protein binding; non-membrane spanning protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity

Biological Process: negative regulation of MAP kinase activity; response to light stimulus; response to cAMP; response to retinoic acid; negative regulation of MAPKKK cascade; positive regulation of apoptosis; response to glucocorticoid stimulus; negative regulation of meiotic cell cycle; response to testosterone stimulus; protein amino acid dephosphorylation; response to estradiol stimulus; cellular response to hormone stimulus; regulation of apoptosis; response to hydrogen peroxide; endoderm formation; response to oxidative stress; response to calcium ion; inactivation of MAPK activity; negative regulation of apoptosis
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Research Articles on DUSP1

1. In lesional psoriatic skin, the p38 MAPK negative feedback mechanism provided by DUSP1 seems to be inhibited and downregulation of DUSP1 may contribute to the sustained inflammatory response seen in psoriasis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DUSP1 antibody

 Reference Product  PubMed Publications
 JUN antibody  >190 publications with DUSP1 and JUN
 MAPK1 antibody  >115 publications with DUSP1 and MAPK1
 MAPK3 antibody  >96 publications with DUSP1 and MAPK3
 FOS antibody  >48 publications with DUSP1 and FOS
 EGR1 antibody  >10 publications with DUSP1 and EGR1
 MAPK8 antibody  >6 publications with DUSP1 and MAPK8
 MAPK14 antibody  >5 publications with DUSP1 and MAPK14
 MAPK9 antibody  >2 publications with DUSP1 and MAPK9
 MAPK12 antibody  >1 publications with DUSP1 and MAPK12

Pathways associated with anti-DUSP1 antibody

 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 ErbB1 Downstream Signaling Pathway antibodies  ErbB1 Downstream Signaling Pathway Diagram
 Fc-epsilon Receptor I Signaling In Mast Cells Pathway antibodies  Fc-epsilon Receptor I Signaling In Mast Cells Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Regulation Of P38-alpha And P38-beta Pathway antibodies  Regulation Of P38-alpha And P38-beta Pathway Diagram
 Serotonergic Synapse Pathway antibodies  Serotonergic Synapse Pathway Diagram

Diseases associated with anti-DUSP1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >145 publications with DUSP1 and Neoplasms
 Inflammation Antibodies  >85 publications with DUSP1 and Inflammation
 Necrosis Antibodies  >79 publications with DUSP1 and Necrosis
 Cardiovascular Diseases Antibodies  >33 publications with DUSP1 and Cardiovascular Diseases
 Lung Diseases Antibodies  >32 publications with DUSP1 and Lung Diseases
 Nervous System Diseases Antibodies  >28 publications with DUSP1 and Nervous System Diseases
 Breast Neoplasms Antibodies  >27 publications with DUSP1 and Breast Neoplasms
 Liver Diseases Antibodies  >27 publications with DUSP1 and Liver Diseases
 Neoplasms, Experimental Antibodies  >22 publications with DUSP1 and Neoplasms, Experimental
 Hypertension Antibodies  >22 publications with DUSP1 and Hypertension

Organs/Tissues associated with anti-DUSP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >82 publications with DUSP1 and Blood
 Muscle Antibodies  >81 publications with DUSP1 and Muscle
 Vascular Antibodies  >67 publications with DUSP1 and Vascular
 Brain Antibodies  >65 publications with DUSP1 and Brain
 Lung Antibodies  >51 publications with DUSP1 and Lung
 Liver Antibodies  >47 publications with DUSP1 and Liver
 Bone Antibodies  >41 publications with DUSP1 and Bone
 Heart Antibodies  >39 publications with DUSP1 and Heart
 Nerve Antibodies  >28 publications with DUSP1 and Nerve
 Kidney Antibodies  >27 publications with DUSP1 and Kidney
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