GRM1 Antibody – Rabbit Polyclonal

mGluR1: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP. Belongs to the G-protein coupled receptor 3 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; GPCR, family 3; Membrane protein, multi-pass; Membrane protein, integral

Cellular Component: neuron projection; integral to plasma membrane; dendrite; postsynaptic density; dendritic spine; integral to membrane; cytosol; presynaptic membrane; postsynaptic membrane; cell soma; membrane; axon; plasma membrane; intracellular; nucleus

Molecular Function: G-protein coupled receptor activity; identical protein binding; signal transducer activity; protein binding; PLC activating metabotropic glutamate receptor activity; estrogen receptor binding; glutamate receptor activity

Biological Process: elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of synaptic transmission, glutamatergic; activation of MAPKK activity; activation of MAPK activity; calcium-mediated signaling; locomotory behavior; signal transduction; sensory perception of pain; G-protein coupled receptor protein signaling pathway; regulation of MAPKKK cascade; metabotropic glutamate receptor, phospholipase C activating pathway; protein kinase C activation; metabotropic glutamate receptor signaling pathway; regulation of sensory perception of pain