Rabbit Anti-UBASH3A Polyclonal Antibody – Cat# MBS641469

UBASH3A Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the UBASH3A antibody detected the UBASH3A protein (arrow).

UBASH3A Antibody – Rabbit Polyclonal

Name: UBASH3A Antibody; Polyclonal; Rabbit; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS641469
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS641469

UBASH3A interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

UBASH3A, Polyclonal Antibody

Full Product Name

UBASH3A, ID (UBASH3A, STS2, Ubiquitin-associated and SH3 domain-containing protein A, Cbl-interacting protein 4, Suppressor of T-cell receptor signaling 2, T-cell ubiquitin ligand 1)

Product Gene Name

anti-UBASH3A antibody

Product Synonym Names

Anti -UBASH3A, ID (UBASH3A, STS2, Ubiquitin-associated and SH3 domain-containing protein A, Cbl-interacting protein 4, Suppressor of T-cell receptor signaling 2, T-cell ubiquitin ligand 1)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Mouse

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Mouse

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

74,123 Da

Chromosome Location

Chromosome: 21; NC_000021.8 (43823971..43867790). Location: 21q22.3

OMIM

605736

3D Structure

ModBase 3D Structure for P57075

Immunogen

UBASH3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 312-340 amino acids from the Central region of human UBASH3A.

Product Categories/Family for anti-UBASH3A antibody

Antibodies; Abs to Ubiquitin

Applications Tested/Suitable for anti-UBASH3A antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-UBASH3A antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-UBASH3A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for UBASH3A purchase

MBS641469 is an antibody targeting UBASH3A. Also known as UBASH3A, ID (UBASH3A, STS2, Ubiquitin-associated and SH3 domain-containing protein A, Cbl-interacting protein 4, Suppressor of T-cell receptor signaling 2, T-cell ubiquitin ligand 1). Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for UBASH3A. It may not necessarily be applicable to this product.

NCBI GI #

343478263

NCBI GeneID

53347

NCBI Accession #

NP_001230396.1

UniProt Primary Accession #

P57075

UniProt Secondary Accession #

Q6HA34; Q6HA35; Q6ISI6; Q6ISK3; Q6ISS9; G5E9E4

UniProt Related Accession #

P57075

GenBank Nucleotide #

NM_001243467.1

NCBI Official Full Name

ubiquitin-associated and SH3 domain-containing protein A isoform 3

NCBI Official Synonym Full Names

ubiquitin associated and SH3 domain containing A

NCBI Official Symbol

UBASH3A

NCBI Official Synonym Symbols

TULA; CLIP4; STS-2; TULA-1

UniProt Protein Name

Ubiquitin-associated and SH3 domain-containing protein A

UniProt Synonym Protein Names

Cbl-interacting protein 4; CLIP4; Suppressor of T-cell receptor signaling 2; STS-2; T-cell ubiquitin ligand 1

Protein Family

Ubiquitin-associated and SH3 domain-containing protein

UniProt Gene Name

UBASH3A

UniProt Synonym Gene Names

STS2; CLIP4; STS-2; TULA-1

UniProt Entry Name

UBS3A_HUMAN

NCBI Protein Information

ubiquitin-associated and SH3 domain-containing protein A; T-cell ubiquitin ligand 1; cbl-interacting protein 4; T-cell ubiquitin ligand protein; suppressor of T-cell receptor signaling 2

NCBI Summary for UBASH3A

This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

UniProt Comments for UBASH3A

STS2: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein phosphatase, tyrosine (non-receptor)

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: nucleus; cytosol

Biological Process: negative regulation of T cell receptor signaling pathway; regulation of cytokine production

Research Articles on UBASH3A

1. Results suggest that UBASH3a gene plays a role in the susceptibility to systemic lupus erythematosus and UBASH3a can be considered as a common genetic factor in autoimmune diseases.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-UBASH3A antibody

Reference Product	PubMed Publications
UBE2L3 antibody	>1 publications with UBASH3A and UBE2L3

Diseases associated with anti-UBASH3A antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>1 publications with UBASH3A and Nervous System Diseases
Neoplasms Antibodies	>1 publications with UBASH3A and Neoplasms

Organs/Tissues associated with anti-UBASH3A antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>6 publications with UBASH3A and Blood
Thyroid Antibodies	>1 publications with UBASH3A and Thyroid
Spleen Antibodies	>1 publications with UBASH3A and Spleen