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WIPI1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS641495

WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI… More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
WIPI1, Polyclonal Antibody
Full Product Name
WIPI1, NT (WIPI1, WIPI49, WD repeat domain phosphoinositide-interacting protein 1, Atg18 protein homolog, WD40 repeat protein interacting with phosphoinositides of 49kD)
Product Gene Name
anti-WIPI1 antibody
Product Synonym Names
Anti -WIPI1, NT (WIPI1, WIPI49, WD repeat domain phosphoinositide-interacting protein 1, Atg18 protein homolog, WD40 repeat protein interacting with phosphoinositides of 49kD)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Purified
Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
48,673 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (66417422..66453653, complement). Location: 17q24.2
OMIM
609224
3D Structure
ModBase 3D Structure for Q5MNZ9
Immunogen
WIPI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-59 amino acids from the N-terminal region of human WIPI1.

Product Categories/Family for anti-WIPI1 antibody

Antibodies; Abs to WD Repeat Proteins
Applications Tested/Suitable for anti-WIPI1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-WIPI1 antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Western Blot (WB) of anti-WIPI1 antibody

WIPI1 Antibody (N-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the WIPI1 antibody detected the WIPI1 protein (arrow).
Rabbit Anti-WIPI1 Polyclonal Antibody – Cat# MBS641495

Other Notes

Small volumes of anti-WIPI1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for WIPI1 purchase

MBS641495 is an antibody targeting WIPI1. Also known as WIPI1, NT (WIPI1, WIPI49, WD repeat domain phosphoinositide-interacting protein 1, Atg18 protein homolog, WD40 repeat protein interacting with phosphoinositides of 49kD). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for WIPI1. It may not necessarily be applicable to this product.

NCBI GI #
157388939
NCBI GeneID
55062
NCBI Accession #
NP_060453.3
UniProt Primary Accession #
Q5MNZ9
UniProt Secondary Accession #
Q8IXM5; Q9NWF8
UniProt Related Accession #
Q5MNZ9
GenBank Nucleotide #
NM_017983.5
NCBI Official Full Name
WD repeat domain phosphoinositide-interacting protein 1
NCBI Official Synonym Full Names
WD repeat domain, phosphoinositide interacting 1
NCBI Official Symbol
WIPI1
NCBI Official Synonym Symbols
ATG18; ATG18A; WIPI49
UniProt Protein Name
WD repeat domain phosphoinositide-interacting protein 1
UniProt Synonym Protein Names
Atg18 protein homolog; WD40 repeat protein interacting with phosphoinositides of 49 kDa
Protein Family
WD repeat domain phosphoinositide-interacting protein
UniProt Gene Name
WIPI1
UniProt Synonym Gene Names
WIPI49; WIPI-1; WIPI 49 kDa
UniProt Entry Name
WIPI1_HUMAN
NCBI Protein Information
WD repeat domain phosphoinositide-interacting protein 1; WIPI 49 kDa; WIPI-1 alpha; atg18 protein homolog; WD40 repeat protein Interacting with phosphoInositides of 49kDa; WD40 repeat protein interacting with phosphoinositides of 49 kDa

UniProt Comments for WIPI1

ATG18: May play a role in autophagy. May regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway. Probably interacts with androgen (AR) and the estrogen receptor (ER). Binds PtdIns3P and to a lesser extent, PtdIns3,5P2 and PtdIns5P in vitro. Interaction with PtdIns3P is required for recruitment to membranes. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Autophagy

Chromosomal Location of Human Ortholog: 17q24.2

Cellular Component: Golgi membrane; extrinsic to membrane; cytoskeleton; clathrin-coated vesicle; pre-autophagosomal structure membrane; cytoplasm; endosome membrane; trans-Golgi network; cytosol

Molecular Function: androgen receptor binding; estrogen receptor binding; phosphatidylinositol 3-phosphate binding; receptor binding

Biological Process: unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; unfolded protein response; protein amino acid lipidation; mitochondrion degradation; autophagy; cellular response to nitrogen starvation; autophagic vacuole formation; vesicle targeting, trans-Golgi to endosome
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Research Articles on WIPI1

1. Freeze-fracture replica immunolabelling reveals WD-repeat protein interacting with phosphoinositides 1 and 2 (WIPI-1 and WIPI-2) as membrane components of autophagosomes and the plasma membrane (PM).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-WIPI1 antibody

 Reference Product  PubMed Publications
 ULK1 antibody  >4 publications with WIPI1 and ULK1
 ATG7 antibody  >1 publications with WIPI1 and ATG7
 BECN1 antibody  >1 publications with WIPI1 and BECN1

Pathways associated with anti-WIPI1 antibody

 Products by Pathway  Pathway Diagram
 Activation Of Chaperone Genes By XBP1(S) Pathway antibodies  Activation Of Chaperone Genes By XBP1(S) Pathway Diagram
 Activation Of Chaperones By IRE1alpha Pathway antibodies  Activation Of Chaperones By IRE1alpha Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Unfolded Protein Response Pathway antibodies  Unfolded Protein Response Pathway Diagram

Diseases associated with anti-WIPI1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2 publications with WIPI1 and Neoplasms

Organs/Tissues associated with anti-WIPI1 antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >3 publications with WIPI1 and Heart
 Blood Antibodies  >1 publications with WIPI1 and Blood
 Eye Antibodies  >1 publications with WIPI1 and Eye
 Kidney Antibodies  >1 publications with WIPI1 and Kidney
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