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IKBKAP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS641497

Its function is not clear, but it has been demonstrated that the human Elongator facilitates transcription by RNA polymerase II in a chromatin- and acetyl-CoA-dependent manner. IKBKAP. IKBKAP was originally described as a scaffold protein of the IKK complex… More details

$915 / 0.05 mg +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
ELP1 (IKBKAP), Polyclonal Antibody
Full Product Name
ELP1, CT (Elongator Complex Protein 1, IkappaB Kinase Complex-associated Protein, IKK Complex-associated Protein, IKBKAP, IKAP, p150)
Product Gene Name
anti-IKBKAP antibody
Product Synonym Names
Anti -ELP1, CT (Elongator Complex Protein 1, IkappaB Kinase Complex-associated Protein, IKK Complex-associated Protein, IKBKAP, IKAP, p150)
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.02% sodium azide.
Purity/Purification
Purified
Purified
Specificity
Recognizes human IKBKAP. Species sequence homology: Mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
150,254 Da
Chromosome Location
Chromosome: 9; NC_000009.11 (111629800..111696608, complement). Location: 9q31
OMIM
223900
3D Structure
ModBase 3D Structure for O95163
Immunogen
Synthetic peptide corresponding to 16aa from human IKBKAP at C-terminal (KLH).

Product Categories/Family for anti-IKBKAP antibody

Antibodies; Abs to Protein Kinases
Applications Tested/Suitable for anti-IKBKAP antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
Application Notes for anti-IKBKAP antibody
Suitable for use in Western Blot, Immunocytochemistry and Immunohistochemistry.
Dilution: Western Blot: 0.5-1ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 2.5ug/ml

Immunohistochemistry (IHC) of anti-IKBKAP antibody

Human Prostate (formalin-fixed, paraffin-embedded) stained with IKBKAP antibody a 2.5ug/ml followed by biotinylated goat rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.
Rabbit Anti-IKBKAP Polyclonal Antibody – Cat# MBS641497

Immunohistochemistry (IHC) of anti-IKBKAP antibody

Human Testis (formalin-fixed, paraffin-embedded) stained with IKBKAP antibody at 2.5ug/ml followed by biotinylated goat rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.
Rabbit Anti-IKBKAP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS641497

Other Notes

Small volumes of anti-IKBKAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IKBKAP purchase

MBS641497 is an antibody targeting IKBKAP. Also known as ELP1, CT (Elongator Complex Protein 1, IkappaB Kinase Complex-associated Protein, IKK Complex-associated Protein, IKBKAP, IKAP, p150). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IKBKAP. It may not necessarily be applicable to this product.

NCBI GI #
38569394
NCBI GeneID
8518
NCBI Accession #
NP_003631.2
UniProt Primary Accession #
O95163
UniProt Secondary Accession #
Q5JSV2; Q9H327; Q9UG87
UniProt Related Accession #
O95163
GenBank Nucleotide #
NM_003640.3
NCBI Official Full Name
elongator complex protein 1
NCBI Official Synonym Full Names
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
NCBI Official Symbol
IKBKAP
NCBI Official Synonym Symbols
FD; DYS; ELP1; IKAP; IKI3; TOT1
UniProt Protein Name
Elongator complex protein 1
UniProt Synonym Protein Names
IkappaB kinase complex-associated protein; IKK complex-associated protein; p150
Protein Family
Putative elongator complex protein
UniProt Gene Name
IKBKAP
UniProt Synonym Gene Names
ELP1; IKAP; ELP1
UniProt Entry Name
ELP1_HUMAN
NCBI Protein Information
elongator complex protein 1; p150; IKK complex-associated protein; ikappaB kinase complex-associated protein; elongator acetyltransferase complex subunit 1

NCBI Summary for IKBKAP

The protein encoded by this gene is a scaffold protein and a regulator for 3 different kinases involved in proinflammatory signaling. This encoded protein can bind NF-kappa-B-inducing kinase (NIK) and IKKs through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. [provided by RefSeq, Jul 2008]
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UniProt Comments for IKBKAP

IKBKAP: May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK). Interacts preferentially with MAP3K14/NIK followed by IKK-alpha and IKK-beta. Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, and two yet unidentified proteins, p30 and p38. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit. Interacts with ELP3. Belongs to the ELP1/IKA1 family.

Protein type: Protein kinase, regulatory subunit; Transcription regulation

Chromosomal Location of Human Ortholog: 9q31

Cellular Component: transcription elongation factor complex; Elongator holoenzyme complex; cytoplasm; nucleolus; histone acetyltransferase complex

Molecular Function: protein binding; signal transducer activity; phosphorylase kinase regulator activity

Biological Process: regulation of transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; RNA elongation from RNA polymerase II promoter; immune response; protein complex assembly; regulation of protein kinase activity; signal transduction; protein amino acid phosphorylation; positive regulation of cell migration

Disease: Neuropathy, Hereditary Sensory And Autonomic, Type Iii
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Research Articles on IKBKAP

1. Digoxin-mediated repression of SRSF3 expression plays a role in the digoxin-mediated inclusion of exon 20 in the IKBKAP transcript generated from the familial dysautonomia mutant allele.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IKBKAP antibody

 Reference Product  PubMed Publications
 ELP3 antibody  >3 publications with IKBKAP and ELP3
 ELP2 antibody  >1 publications with IKBKAP and ELP2

Pathways associated with anti-IKBKAP antibody

 Products by Pathway  Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram

Diseases associated with anti-IKBKAP antibody

 Disease Name  Pubmed Publications
 Dysautonomia, Familial Antibodies  >65 publications with IKBKAP and Dysautonomia, Familial
 Nervous System Diseases Antibodies  >60 publications with IKBKAP and Nervous System Diseases
 Congenital Abnormalities Antibodies  >57 publications with IKBKAP and Congenital Abnormalities
 Autoimmune Diseases Antibodies  >57 publications with IKBKAP and Autoimmune Diseases
 Death Antibodies  >9 publications with IKBKAP and Death
 Necrosis Antibodies  >8 publications with IKBKAP and Necrosis
 Cardiovascular Diseases Antibodies  >7 publications with IKBKAP and Cardiovascular Diseases
 Inflammation Antibodies  >5 publications with IKBKAP and Inflammation
 Disease Models, Animal Antibodies  >3 publications with IKBKAP and Disease Models, Animal
 Movement Disorders Antibodies  >3 publications with IKBKAP and Movement Disorders

Organs/Tissues associated with anti-IKBKAP antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >14 publications with IKBKAP and Blood
 Brain Antibodies  >13 publications with IKBKAP and Brain
 Muscle Antibodies  >5 publications with IKBKAP and Muscle
 Heart Antibodies  >4 publications with IKBKAP and Heart
 Embryonic Tissue Antibodies  >4 publications with IKBKAP and Embryonic Tissue
 Liver Antibodies  >2 publications with IKBKAP and Liver
 Skin Antibodies  >2 publications with IKBKAP and Skin
 Kidney Antibodies  >2 publications with IKBKAP and Kidney
 Mouth Antibodies  >2 publications with IKBKAP and Mouth
 Prostate Antibodies  >1 publications with IKBKAP and Prostate
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