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PTN Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS641573

Pleiotrophin or Neurite Growth-promoting Factor 1 (NEGF1), also called Heparin Affin Regulatory Peptide (HARP) or Heparin Binding Growth associated molecule (HB-GAM) is an 18-kD growth factor that has a high affinity for heparin. It is structurally related to… More details

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Product Overview

Online Datasheet in PDF
Product Name
PTN, Polyclonal Antibody
Full Product Name
PTN, NT (Pleiotrophin, Heparin-binding Growth-associated Molecule, HB-GAM, Heparin-binding Growth Factor 8, HBGF-8, Osteoblast-specific Factor 1, OSF-1, Heparin-binding Neurite Outgrowth-promoting Factor 1, HBNF-1, Heparin-binding Brain Mitogen, HBBM, HBN
Product Gene Name
anti-PTN antibody
Product Synonym Names
Anti -PTN, NT (Pleiotrophin, Heparin-binding Growth-associated Molecule, HB-GAM, Heparin-binding Growth Factor 8, HBGF-8, Osteoblast-specific Factor 1, OSF-1, Heparin-binding Neurite Outgrowth-promoting Factor 1, HBNF-1, Heparin-binding Brain Mitogen, HBBM, HBN
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human PTN at ~19kD.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
18,942 Da
Chromosome Location
Chromosome: 7; NC_000007.13 (136912088..137028606, complement). Location: 7q33
OMIM
162095
3D Structure
ModBase 3D Structure for P21246
Immunogen
Synthetic peptide corresponding to aa25-55 at the N-terminal region of human PTN, conjugated to KLH. Species Sequence Homology: bovine, mouse, porcine and rat

Product Categories/Family for anti-PTN antibody

Antibodies; Abs to Neurotrophins
Applications Tested/Suitable for anti-PTN antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PTN antibody
Suitable for use in Western Blot and Immunohistochemistry.
Dilution: Immunohistochemistry: 1:10-1:50
Western Blot: 1:50-1:100

Western Blot (WB) of anti-PTN antibody

PTN Antibody (N-term) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the PTN antibody detected the PTN protein (arrow).
Rabbit Anti-PTN Polyclonal Antibody – Cat# MBS641573

Immunohistochemistry (IHC) of anti-PTN antibody

PTN Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PTN Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-PTN Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS641573

Other Notes

Small volumes of anti-PTN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PTN purchase

MBS641573 is an antibody targeting PTN. Also known as PTN, NT (Pleiotrophin, Heparin-binding Growth-associated Molecule, HB-GAM, Heparin-binding Growth Factor 8, HBGF-8, Osteoblast-specific Factor 1, OSF-1, Heparin-binding Neurite Outgrowth-promoting Factor 1, HBNF-1, Heparin-binding Brain Mitogen, HBBM, HBN. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PTN. It may not necessarily be applicable to this product.

NCBI GI #
4506281
NCBI GeneID
5764
NCBI Accession #
NP_002816.1
UniProt Primary Accession #
P21246
UniProt Secondary Accession #
Q5U0B0; Q6ICQ5; Q9UCC6
UniProt Related Accession #
P21246
GenBank Nucleotide #
NM_002825.5
NCBI Official Full Name
pleiotrophin
NCBI Official Synonym Full Names
pleiotrophin
NCBI Official Symbol
PTN
NCBI Official Synonym Symbols
HARP; HBNF; HBGF8; NEGF1
UniProt Protein Name
Pleiotrophin
UniProt Synonym Protein Names
Heparin-binding brain mitogen; HBBM; Heparin-binding growth factor 8; HBGF-8; Heparin-binding growth-associated molecule; HB-GAM; Heparin-binding neurite outgrowth-promoting factor 1; HBNF-1; Osteoblast-specific factor 1
Protein Family
Pleiotrophin
UniProt Gene Name
PTN
UniProt Synonym Gene Names
HBNF1; NEGF1; PTN; HBBM; HBGF-8; HB-GAM; HBNF-1; OSF-1
UniProt Entry Name
PTN_HUMAN
NCBI Protein Information
pleiotrophin; HBBM; OSF-1; HB-GAM; HBGF-8; HBNF-1; osteoblast-specific factor 1; heparin-binding brain mitogen; heparin binding growth factor 8; heparin-binding growth factor 8; heparin affin regulatory protein; neurite growth-promoting factor 1; heparin-binding growth-associated molecule; heparin-binding neurite outgrowth-promoting factor 1; pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)

UniProt Comments for PTN

PTN: Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti- apoptotic signaling of PTN and regulation of cell proliferation. Belongs to the pleiotrophin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7q33

Cellular Component: extracellular space; endoplasmic reticulum

Molecular Function: heparin binding; growth factor activity; protein phosphatase inhibitor activity

Biological Process: nervous system development; positive regulation of cell division; negative regulation of catalytic activity; positive regulation of cell proliferation; learning; transmembrane receptor protein tyrosine phosphatase signaling pathway; bone mineralization
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Research Articles on PTN

1. PTN is able to induce ex vivo angiogenesis during aging.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PTN antibody

 Reference Product  PubMed Publications
 ALK antibody  >23 publications with PTN and ALK
 PTPRZ1 antibody  >18 publications with PTN and PTPRZ1
 SDC3 antibody  >7 publications with PTN and SDC3
 VEGFA antibody  >6 publications with PTN and VEGFA
 SRC antibody  >4 publications with PTN and SRC
 PTEN antibody  >3 publications with PTN and PTEN
 SDC1 antibody  >3 publications with PTN and SDC1
 KDR antibody  >2 publications with PTN and KDR

Pathways associated with anti-PTN antibody

 Products by Pathway  Pathway Diagram
 Syndecan-3-mediated Signaling Events Pathway antibodies  Syndecan-3-mediated Signaling Events Pathway Diagram

Diseases associated with anti-PTN antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >62 publications with PTN and Carcinoma
 Brain Diseases Antibodies  >40 publications with PTN and Brain Diseases
 Cardiovascular Diseases Antibodies  >26 publications with PTN and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >24 publications with PTN and Breast Neoplasms
 Lung Neoplasms Antibodies  >20 publications with PTN and Lung Neoplasms
 Inflammation Antibodies  >12 publications with PTN and Inflammation
 Necrosis Antibodies  >12 publications with PTN and Necrosis
 Neoplasms, Experimental Antibodies  >12 publications with PTN and Neoplasms, Experimental
 Carcinoma, Squamous Cell Antibodies  >11 publications with PTN and Carcinoma, Squamous Cell
 Liver Diseases Antibodies  >7 publications with PTN and Liver Diseases

Organs/Tissues associated with anti-PTN antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >174 publications with PTN and Brain
 Bone Antibodies  >64 publications with PTN and Bone
 Vascular Antibodies  >59 publications with PTN and Vascular
 Muscle Antibodies  >55 publications with PTN and Muscle
 Embryonic Tissue Antibodies  >33 publications with PTN and Embryonic Tissue
 Lung Antibodies  >24 publications with PTN and Lung
 Heart Antibodies  >20 publications with PTN and Heart
 Skin Antibodies  >17 publications with PTN and Skin
 Connective Tissue Antibodies  >17 publications with PTN and Connective Tissue
 Liver Antibodies  >15 publications with PTN and Liver
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