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JHDM1D Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS641591

MBS641591 is an antibody targeting JHDM1D. Also known as JHDM1D, ID (JHDM1D, KDM7, KIAA1718, Lysine-specific demethylase 7, JmjC domain-containing histone demethylation protein 1D). Reactive in Human. Host: Rabbit. More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
JHDM1D, Polyclonal Antibody
Full Product Name
JHDM1D, ID (JHDM1D, KDM7, KIAA1718, Lysine-specific demethylase 7, JmjC domain-containing histone demethylation protein 1D)
Product Gene Name
anti-JHDM1D antibody
Product Synonym Names
Anti -JHDM1D, ID (JHDM1D, KDM7, KIAA1718, Lysine-specific demethylase 7, JmjC domain-containing histone demethylation protein 1D)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
106,557 Da
Chromosome Location
Chromosome: 7; NC_000007.13 (139784546..139876741, complement). Location: 7q34
3D Structure
ModBase 3D Structure for Q6ZMT4
Immunogen
JHDM1D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 295-325 amino acids from the Central region of human JHDM1D.

Product Categories/Family for anti-JHDM1D antibody

Antibodies; Abs to Histones
Applications Tested/Suitable for anti-JHDM1D antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-JHDM1D antibody
Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100
Flow Cytometry: 1:10-50

Western Blot (WB) of anti-JHDM1D antibody

Western blot analysis of JHDM1D Antibody (Center) in 293 cell line lysates (35ug/lane).JHDM1D (arrow) was detected using the purified Pab.
Rabbit Anti-JHDM1D Polyclonal Antibody – Cat# MBS641591

Immunohistochemistry (IHC) of anti-JHDM1D antibody

JHDM1D Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the JHDM1D Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-JHDM1D Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS641591

Flow Cytometry (FC/FACS) of anti-JHDM1D antibody

JHDM1D Antibody (Center) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-JHDM1D Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS641591

Other Notes

Small volumes of anti-JHDM1D antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for JHDM1D. It may not necessarily be applicable to this product.

NCBI GI #
117558014
NCBI GeneID
80853
NCBI Accession #
AAI27008.1
UniProt Primary Accession #
Q6ZMT4
UniProt Secondary Accession #
Q6MZL8; Q9C0E5; A4D1S9; C9JJH9; C9JQU2
UniProt Related Accession #
Q6ZMT4
NCBI Official Full Name
JHDM1D protein
NCBI Official Synonym Full Names
jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae)
NCBI Official Symbol
JHDM1D
NCBI Official Synonym Symbols
KDM7A
UniProt Protein Name
Lysine-specific demethylase 7
UniProt Synonym Protein Names
JmjC domain-containing histone demethylation protein 1D
UniProt Gene Name
JHDM1D
UniProt Synonym Gene Names
KDM7; KIAA1718
UniProt Entry Name
KDM7_HUMAN
NCBI Protein Information
lysine-specific demethylase 7; histone lysine demethylase JHDM1D; jmjC domain-containing histone demethylation protein 1D; jumonji C domain-containing histone demethylase 1 homolog D

UniProt Comments for JHDM1D

JHDM1D: Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate. Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.11.-

Chromosomal Location of Human Ortholog: 7q34

Cellular Component: nucleoplasm; nucleolus; nucleus

Molecular Function: zinc ion binding; histone demethylase activity (H3-K36 specific); iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; histone demethylase activity (H3-K9 specific); methylated histone residue binding

Biological Process: establishment and/or maintenance of chromatin architecture; histone H3-K9 demethylation; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; midbrain development
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Research Articles on JHDM1D

1. increased JHDM1D expression suppresses tumor growth by down-regulating angiogenesis under nutrient starvation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-JHDM1D antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2 publications with JHDM1D and Neoplasms
 Neovascularization, Pathologic Antibodies  >1 publications with JHDM1D and Neovascularization, Pathologic
 Neoplasm Invasiveness Antibodies  >1 publications with JHDM1D and Neoplasm Invasiveness
 Neoplasms, Experimental Antibodies  >1 publications with JHDM1D and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >1 publications with JHDM1D and Breast Neoplasms

Organs/Tissues associated with anti-JHDM1D antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1 publications with JHDM1D and Blood
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