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MPZL1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS641607

PZR (Protein zero related) is an immunoglobulin superfamily protein that specifically binds the tyrosine phosphatase SHP-2 through its intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIMs). PZR is phosphorylated by c-Src, c-Fyn, c-Lyn, Csk,… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PZR (MPZL1), Polyclonal Antibody
Full Product Name
PZR (Myelin Protein Zero-like Protein 1, Protein Zero-related, MPZL1, UNQ849/PRO1787)
Product Gene Name
anti-MPZL1 antibody
Product Synonym Names
Anti -PZR (Myelin Protein Zero-like Protein 1, Protein Zero-related, MPZL1, UNQ849/PRO1787)
Immunogen Sequence
MAASAGAGAV IAAPDSRRWL WSVLAAALGL LTAGVSALEV YTPKEIFVAN GTQGKLTCKF KSTSTTGGLT SVSWSFQPEG ADTTVSFFHY SQGQVYLGNY PPFKDRISWA GDLDKKDASI NIENMQFIHN GTYICDVKNP PDIVVQPGHI RLYVVEKENL PVFPVWVVVG IVTAVVLGLT LLISMILAVL YRRKNSKRDY TGCSTSESLS PVKQAPRKSP SDTEGLVKSL PSGSHQGPVI YAQLDHSGGH HSDKINKSES VVYADIRKN
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid.
Purity/Purification
Serum
Serum
Specificity
Recognizes human MPZL1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
29,082 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (167691187..167761156). Location: 1q24.2
OMIM
604376
3D Structure
ModBase 3D Structure for O95297
Immunogen
Full length human MPZL1, aa1-269 (NP_003944.1).

Product Categories/Family for anti-MPZL1 antibody

Antibodies; Abs to Tyrosine Kinases
Applications Tested/Suitable for anti-MPZL1 antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-MPZL1 antibody
Suitable for use in Immunoprecipitation and Western Blot.

Western Blot (WB) of anti-MPZL1 antibody

Western Blot analysis of MPZL1 expression in transfected 293T cell line by MPZL1 polyclonal antibody. Lane 1: MPZL1 transfected lysate (29.1kD). Lane 2: Non-transfected lysate.
Rabbit Anti-MPZL1 Polyclonal Antibody – Cat# MBS641607

Immunoprecipitation (IP) of anti-MPZL1 antibody

Immunoprecipitation of MPZL1 transfected lysate using MPZL1 rabbit polyclonal antibody and Protein A Magnetic Bead and immunoblotted with MPZL1 mouse polyclonal antibody
Rabbit Anti-MPZL1 Polyclonal Antibody, Immunoprecipitation (IP) – Cat# MBS641607

Other Notes

Small volumes of anti-MPZL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MPZL1 purchase

MBS641607 is an antibody targeting MPZL1. Also known as PZR (Myelin Protein Zero-like Protein 1, Protein Zero-related, MPZL1, UNQ849/PRO1787). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MPZL1. It may not necessarily be applicable to this product.

NCBI GI #
3851145
NCBI GeneID
9019
NCBI Accession #
AAC72231.1
UniProt Primary Accession #
O95297
UniProt Secondary Accession #
Q5R332; Q8IX11; Q9BWZ3; Q9NYK4; Q9UL20; B2REB9; B2REC0
UniProt Related Accession #
O95297
NCBI Official Full Name
protein zero related protein
NCBI Official Synonym Full Names
myelin protein zero-like 1
NCBI Official Symbol
MPZL1
NCBI Official Synonym Symbols
PZR; PZRa; PZRb; PZR1b; MPZL1b
UniProt Protein Name
Myelin protein zero-like protein 1
UniProt Synonym Protein Names
Protein zero-related
Protein Family
Myelin protein zero-like protein
UniProt Gene Name
MPZL1
UniProt Synonym Gene Names
PZR
UniProt Entry Name
MPZL1_HUMAN
NCBI Protein Information
myelin protein zero-like protein 1; protein zero related; protein zero-related; immunoglobulin family transmembrane protein

UniProt Comments for MPZL1

PZR: an immunoglobulin superfamily cell surface protein. Contains two tyrosine-based inhibition motifs (ITIMs) responsible for binding of SHP-2. When phosphorylated, it can specifically bind SHP-2, blocking its translocation, and interupting its function. Treatment of several cell lines with ConA caused tyrosine phosphorylation of PZR. Two alternatively spliced isoforms have been reported. One isoform, PZR1b, lacks the ITIMs and has a dominant negative effect upon full-length PZR and its recruitment of SHP-2.

Protein type: Adaptor/scaffold; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q24.2

Cellular Component: cell surface; focal adhesion; integral to plasma membrane

Molecular Function: protein binding; structural molecule activity

Biological Process: cell-cell signaling; transmembrane receptor protein tyrosine kinase signaling pathway
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Research Articles on MPZL1

1. Clinico-electrophysiological features and MRI findings are described in leg musculature from three patients belonging to a CMT2J pedigree due to MPZ Thr124Met mutation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MPZL1 antibody

 Reference Product  PubMed Publications
 PTPN11 antibody  >5 publications with MPZL1 and PTPN11
 SRC antibody  >3 publications with MPZL1 and SRC
 PTPN6 antibody  >2 publications with MPZL1 and PTPN6

Pathways associated with anti-MPZL1 antibody

 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram

Diseases associated with anti-MPZL1 antibody

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >6 publications with MPZL1 and Congenital Abnormalities
 Neurodegenerative Diseases Antibodies  >5 publications with MPZL1 and Neurodegenerative Diseases
 Disease Models, Animal Antibodies  >1 publications with MPZL1 and Disease Models, Animal
 Heart Defects, Congenital Antibodies  >1 publications with MPZL1 and Heart Defects, Congenital

Organs/Tissues associated with anti-MPZL1 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >3 publications with MPZL1 and Nerve
 Blood Antibodies  >2 publications with MPZL1 and Blood
 Muscle Antibodies  >2 publications with MPZL1 and Muscle
 Embryonic Tissue Antibodies  >2 publications with MPZL1 and Embryonic Tissue
 Kidney Antibodies  >1 publications with MPZL1 and Kidney
 Eye Antibodies  >1 publications with MPZL1 and Eye
 Vascular Antibodies  >1 publications with MPZL1 and Vascular
 Pancreas Antibodies  >1 publications with MPZL1 and Pancreas
 Placenta Antibodies  >1 publications with MPZL1 and Placenta
 Heart Antibodies  >1 publications with MPZL1 and Heart
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