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DUSP5 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS641635

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate… More details

$880 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DUSP5, Monoclonal Antibody
Full Product Name
DUSP5 (Dual Specificity Protein Phosphatase 5, Dual Specificity Protein Phosphatase hVH3, VH3)
Product Gene Name
anti-DUSP5 antibody
Product Synonym Names
Anti -DUSP5 (Dual Specificity Protein Phosphatase 5, Dual Specificity Protein Phosphatase hVH3, VH3)
Immunogen Sequence
LKEAFDYIKQ RRSMVSPNFG FMGQLLQYES EILPSTPNPQ PPSCQGEAAG SSLIGHLQTL SPDMQGAYCT FPASVLAPVP THSTVSELSR SPVATATSC
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
4C8
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human DUSP5.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
42,047 Da
Chromosome Location
Chromosome: 10; NC_000010.10 (112257625..112271302). Location: 10q25
OMIM
603069
3D Structure
ModBase 3D Structure for Q16690
Immunogen
Partial recombinant corresponding to aa286-384 from human DUSP5 (NP_004410) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-DUSP5 antibody

Antibodies; Abs to Enzymes; Phosphatase
Applications Tested/Suitable for anti-DUSP5 antibody
ELISA (EL/EIA), Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-DUSP5 antibody
Suitable for use in Immunofluorescence, ELISA and Western Blot.
Dilution: Immunofluorescence: 10ug/ml

Western Blot (WB) of anti-DUSP5 antibody

Western Blot detection against Immunogen (36.63kD).
Mouse Anti-DUSP5 Monoclonal Antibody – Cat# MBS641635

Western Blot (WB) of anti-DUSP5 antibody

DUSP5 monoclonal antibody, Western Blot analysis of DUSP5 expression in K-562.
Mouse Anti-DUSP5 Monoclonal Antibody, Western Blot (WB) – Cat# MBS641635

Immunofluorescence (IF) of anti-DUSP5 antibody

Immunofluorescence of monoclonal antibody to DUSP5 on HeLa cell. [antibody concentration 10ug/ml].
Mouse Anti-DUSP5 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS641635

Testing Data of anti-DUSP5 antibody

Detection limit for recombinant GST tagged DUSP5 is ~0.3ng/ml as a capture antibody.
Mouse Anti-DUSP5 Monoclonal Antibody, Testing Data – Cat# MBS641635

Other Notes

Small volumes of anti-DUSP5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DUSP5 purchase

MBS641635 is an antibody targeting DUSP5. Also known as DUSP5 (Dual Specificity Protein Phosphatase 5, Dual Specificity Protein Phosphatase hVH3, VH3). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for DUSP5. It may not necessarily be applicable to this product.

NCBI GI #
62865890
NCBI GeneID
1847
NCBI Accession #
NP_004410.3
UniProt Primary Accession #
Q16690
UniProt Secondary Accession #
Q12997; Q5T603
UniProt Related Accession #
Q16690
GenBank Nucleotide #
NM_004419.3
NCBI Official Full Name
dual specificity protein phosphatase 5
NCBI Official Synonym Full Names
dual specificity phosphatase 5
NCBI Official Symbol
DUSP5
NCBI Official Synonym Symbols
DUSP; HVH3
UniProt Protein Name
Dual specificity protein phosphatase 5
UniProt Synonym Protein Names
Dual specificity protein phosphatase hVH3
Protein Family
Dual specificity protein phosphatase
UniProt Gene Name
DUSP5
UniProt Synonym Gene Names
VH3
UniProt Entry Name
DUS5_HUMAN
NCBI Protein Information
dual specificity protein phosphatase 5; VH1-like phosphatase 3; dual specificity protein phosphatase hVH3; serine/threonine specific protein phosphatase

UniProt Comments for DUSP5

DUSP5: a dual-specificity protein phosphatase containing one Rhodanese domain. Is a direct transcriptional target of p53. Targets include phosphorylated MAP kinases. Overexpression suppresses the growth of several types of human cancer cells. Induced by IL-2, IL-7, and IL-15 but not IL-4 in T cells.

Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; EC 3.1.3.16; Protein phosphatase, dual-specificity

Chromosomal Location of Human Ortholog: 10q25

Cellular Component: nucleus

Molecular Function: protein binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity

Biological Process: endoderm formation; protein amino acid dephosphorylation; inactivation of MAPK activity
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Research Articles on DUSP5

1. DUSP5 methylation may serve as a prognostic marker for gastric cancer (GC), but this requires validation in a larger set of GC samples.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DUSP5 antibody

 Reference Product  PubMed Publications
 MAPK3 antibody  >12 publications with DUSP5 and MAPK3
 MAPK1 antibody  >12 publications with DUSP5 and MAPK1
 SNRK antibody  >1 publications with DUSP5 and SNRK
 MAPK8 antibody  >1 publications with DUSP5 and MAPK8
 TP53 antibody  >1 publications with DUSP5 and TP53

Pathways associated with anti-DUSP5 antibody

 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram

Diseases associated with anti-DUSP5 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >14 publications with DUSP5 and Neoplasms
 Necrosis Antibodies  >4 publications with DUSP5 and Necrosis
 Cardiovascular Diseases Antibodies  >3 publications with DUSP5 and Cardiovascular Diseases
 Inflammation Antibodies  >3 publications with DUSP5 and Inflammation
 Nervous System Diseases Antibodies  >2 publications with DUSP5 and Nervous System Diseases
 Kidney Diseases Antibodies  >2 publications with DUSP5 and Kidney Diseases
 Neoplasms, Experimental Antibodies  >2 publications with DUSP5 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >2 publications with DUSP5 and Breast Neoplasms
 Hyperplasia Antibodies  >2 publications with DUSP5 and Hyperplasia
 Brain Diseases Antibodies  >2 publications with DUSP5 and Brain Diseases

Organs/Tissues associated with anti-DUSP5 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >14 publications with DUSP5 and Blood
 Brain Antibodies  >8 publications with DUSP5 and Brain
 Kidney Antibodies  >5 publications with DUSP5 and Kidney
 Nerve Antibodies  >3 publications with DUSP5 and Nerve
 Embryonic Tissue Antibodies  >3 publications with DUSP5 and Embryonic Tissue
 Liver Antibodies  >3 publications with DUSP5 and Liver
 Eye Antibodies  >2 publications with DUSP5 and Eye
 Lung Antibodies  >2 publications with DUSP5 and Lung
 Thyroid Antibodies  >2 publications with DUSP5 and Thyroid
 Muscle Antibodies  >2 publications with DUSP5 and Muscle
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