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efnb2a Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS641653

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and… More details

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Product Overview

Online Datasheet in PDF
Product Name
EFNB2 (efnb2a), Polyclonal Antibody
Full Product Name
EFNB2, ID (EFNB2, EPLG5, HTKL, LERK5, Ephrin-B2, EPH-related receptor tyrosine kinase ligand 5, HTK ligand)
Product Gene Name
anti-efnb2a antibody
Product Synonym Names
Anti -EFNB2, ID (EFNB2, EPLG5, HTKL, LERK5, Ephrin-B2, EPH-related receptor tyrosine kinase ligand 5, HTK ligand)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
36,724 Da
Chromosome Location
Chromosome: 9; NC_007120.5 (27137159..27157051). Location: chromosome: 9
3D Structure
ModBase 3D Structure for O73874
Immunogen
EFNB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 164-194 amino acids from the Central region of human EFNB2.

Product Categories/Family for anti-efnb2a antibody

Antibodies; Abs to Protein Kinases
Applications Tested/Suitable for anti-efnb2a antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-efnb2a antibody
Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50
Immunofluorescence: 1:10-50

Immunohistochemistry (IHC) of anti-efnb2a antibody

EFNB2 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of EFNB2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-efnb2a Polyclonal Antibody – Cat# MBS641653

Western Blot (WB) of anti-efnb2a antibody

EFNB2 Antibody (Center) western blot analysis in Hela,293 cell line lysates (35ug/lane).This demonstrates the EFNB2 antibody detected the EFNB2 protein (arrow).
Rabbit Anti-efnb2a Polyclonal Antibody, Western Blot (WB) – Cat# MBS641653

Immunofluorescence (IF) of anti-efnb2a antibody

Confocal immunofluorescent analysis of EFNB2 Antibody (Center) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Rabbit Anti-efnb2a Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS641653

Other Notes

Small volumes of anti-efnb2a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for efnb2a purchase

MBS641653 is an antibody targeting efnb2a. Also known as EFNB2, ID (EFNB2, EPLG5, HTKL, LERK5, Ephrin-B2, EPH-related receptor tyrosine kinase ligand 5, HTK ligand). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for efnb2a. It may not necessarily be applicable to this product.

NCBI GI #
18858593
NCBI GeneID
30219
NCBI Accession #
NP_571098.1
UniProt Primary Accession #
O73874
UniProt Related Accession #
O73874
GenBank Nucleotide #
NM_131023.1
NCBI Official Full Name
ephrin-B2a
NCBI Official Synonym Full Names
ephrin B2a
NCBI Official Symbol
efnb2a
NCBI Official Synonym Symbols
efnb2; ephrin-B2a; id:ibd5072
UniProt Protein Name
Ephrin-B2a
Protein Family
Ephrin
UniProt Gene Name
efnb2a
UniProt Synonym Gene Names
efnb2
UniProt Entry Name
EFNB2_DANRE
NCBI Protein Information
ephrin-B2a

UniProt Comments for efnb2a

Function: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with ephb4 may play a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration

By similarity.

Subunit structure: Binds to the receptor tyrosine kinase ephb4.

Subcellular location: Membrane; Single-pass type I membrane protein.

Post-translational modification: Inducible phosphorylation of tyrosine residues in the cytoplasmic domain

By similarity.

Sequence similarities: Belongs to the ephrin family.Contains 1 ephrin RBD (ephrin receptor-binding) domain.
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Research Articles on efnb2a

1. We identified ephrinB2a as a target of hif1 pathway activation, showed that knock-down of ephrinB2a rescued the guidance errors, and showed that the receptor ephA4a is expressed in a pattern complementary to the misrouting axons

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-efnb2a antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >1 publications with efnb2a and Eye
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