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PRAME Antibody – Mouse Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS641754

PRAME is a 509aa protein belonging to the PRAME family consisting of 7 LRR (leucine-rich) repeats. It is a tumor antigen expressed in human melanomas and is recognized by cytolytic T lymphocytes. It's overexpression frequently observed in human cancers… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PRAME, Polyclonal Antibody
Full Product Name
PRAME (Preferentially Expressed Antigen of Melanoma, Melanoma Antigen Preferentially Expressed in Tumors, MAPE, CT130, OPA Interacting Protein 4, OPA-interacting Protein 4, Opa-interacting Protein OIP4, OIP4)
Product Gene Name
anti-PRAME antibody
Product Synonym Names
Anti -PRAME (Preferentially Expressed Antigen of Melanoma, Melanoma Antigen Preferentially Expressed in Tumors, MAPE, CT130, OPA Interacting Protein 4, OPA-interacting Protein 4, Opa-interacting Protein OIP4, OIP4)
Immunogen Sequence
MERRRLWGSI QSRYISMSVW TSPRRLVELA GQSLLKDEAL AIAALELLPR ELFPPLFMAA FDGRHSQTLK AMVQAWPFTC LPLGVLMKGQ HLHLETFKAV LDGLDVLLAQ EVRPRRWKLQ VLDLRKNSHQ DFWTVWSGNR ASLYSFPEPE AAQPMTKKRK VDGLSTEAEQ PFIPVEVLVD LFLKEGACDE LFSYLIEKVK RKKNVLRLCC KKLKIFAMPM QDIKMILKMV QLDSIEDLEV TCTWKLPTLA KFSPYLGQMI NLRRLLLSHI HASSYISPEK EEQYIAQFTS QFLSLQCLQA LYVDSLFFLR GRLDQLLRHV MNPLETLSIT NCRLSEGDVM HLSQSPSVSQ LSVLSLSGVM LTDVSPEPLQ ALLERASATL QDLVFDECGI TDDQLLALLP SLSHCSQLTT LSFYGNSISI SALQSLLQHL IGLSNLTHVL YPVPLESYED IHGTLHLERL AYLHARLREL LCELGRPSMV WLSANPCPHC GDRTFYDPEP ILCPCFMPN
Clonality
Polyclonal
Isotype
IgG
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human PRAME.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
57,890 Da
OMIM
606021
3D Structure
ModBase 3D Structure for P78395
Immunogen
Full length human PRAME, aa1-509 (NP_006106.1).

Product Categories/Family for anti-PRAME antibody

Antibodies; Abs to PRAME Proteins
Applications Tested/Suitable for anti-PRAME antibody
Western Blot (WB)
Application Notes for anti-PRAME antibody
Suitable for use in Western Blot.

Western Blot (WB) of anti-PRAME antibody

PRAME polyclonal antibody. Western Blot analysis of PRAME expression in HeLa.
Mouse Anti-PRAME Polyclonal Antibody – Cat# MBS641754

Western Blot (WB) of anti-PRAME antibody

Western Blot analysis of PRAME expression in transfected 293T cell line by PRAME polyclonal antibody. Lane 1: PRAME transfected lysate (55.99kD). Lane 2: Non-transfected lysate.
Mouse Anti-PRAME Polyclonal Antibody, Western Blot (WB) – Cat# MBS641754

Other Notes

Small volumes of anti-PRAME antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRAME purchase

MBS641754 is an antibody targeting PRAME. Also known as PRAME (Preferentially Expressed Antigen of Melanoma, Melanoma Antigen Preferentially Expressed in Tumors, MAPE, CT130, OPA Interacting Protein 4, OPA-interacting Protein 4, Opa-interacting Protein OIP4, OIP4). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for PRAME. It may not necessarily be applicable to this product.

NCBI GI #
47678629
NCBI Accession #
CAG30435.1
UniProt Primary Accession #
P78395
UniProt Secondary Accession #
O43481; Q8IXN8; B2R6Y7
NCBI Official Full Name
PRAME
UniProt Protein Name
Melanoma antigen preferentially expressed in tumors
UniProt Synonym Protein Names
Opa-interacting protein 4; OIP-4; Preferentially expressed antigen of melanoma
Protein Family
Melanoma antigen
UniProt Gene Name
PRAME
UniProt Synonym Gene Names
MAPE; OIP4; OIP-4
UniProt Entry Name
PRAME_HUMAN

UniProt Comments for PRAME

PRAME: Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. Belongs to the PRAME family.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Cancer Testis Antigen (CTA)

Chromosomal Location of Human Ortholog: 22q11.22

Cellular Component: plasma membrane; nucleus

Molecular Function: protein binding; retinoic acid receptor binding

Biological Process: negative regulation of retinoic acid receptor signaling pathway; negative regulation of cell differentiation; transcription, DNA-dependent; apoptosis; regulation of growth; positive regulation of cell proliferation; cell differentiation; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PRAME antibody

 Reference Product  PubMed Publications
 CUL2 antibody  >2 publications with PRAME and CUL2

Diseases associated with anti-PRAME antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >131 publications with PRAME and Neoplasms
 Leukemia Antibodies  >81 publications with PRAME and Leukemia
 Melanoma Antibodies  >78 publications with PRAME and Melanoma
 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Antibodies  >17 publications with PRAME and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
 Sarcoma Antibodies  >9 publications with PRAME and Sarcoma
 Multiple Myeloma Antibodies  >6 publications with PRAME and Multiple Myeloma
 Carcinoma, Renal Cell Antibodies  >5 publications with PRAME and Carcinoma, Renal Cell
 Lung Diseases Antibodies  >4 publications with PRAME and Lung Diseases
 Breast Neoplasms Antibodies  >4 publications with PRAME and Breast Neoplasms
 Ovarian Neoplasms Antibodies  >4 publications with PRAME and Ovarian Neoplasms

Organs/Tissues associated with anti-PRAME antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >60 publications with PRAME and Blood
 Testis Antibodies  >36 publications with PRAME and Testis
 Bone Marrow Antibodies  >26 publications with PRAME and Bone Marrow
 Lung Antibodies  >10 publications with PRAME and Lung
 Brain Antibodies  >8 publications with PRAME and Brain
 Skin Antibodies  >8 publications with PRAME and Skin
 Eye Antibodies  >7 publications with PRAME and Eye
 Kidney Antibodies  >6 publications with PRAME and Kidney
 Lymph Antibodies  >5 publications with PRAME and Lymph
 Connective Tissue Antibodies  >4 publications with PRAME and Connective Tissue
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