Rabbit Anti-SLC5A8 Polyclonal Antibody – Cat# MBS641819

Mouse Slc5a8 Antibody (C-term) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the Mouse Slc5a8 antibody detected the Mouse Slc5a8 protein (arrow).

SLC5A8 Antibody – Rabbit Polyclonal

Name: SLC5A8 Antibody; Polyclonal; Rabbit; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS641819
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS641819

Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate),… More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Slc5a8, Polyclonal Antibody

Full Product Name

Slc5a8, CT (Slc5a8, Smct, Smct1, Sodium-coupled monocarboxylate transporter 1, Electrogenic sodium monocarboxylate cotransporter, Solute carrier family 5 member 8)

Product Gene Name

anti-SLC5A8 antibody

Product Synonym Names

Anti -Slc5a8, CT (Slc5a8, Smct, Smct1, Sodium-coupled monocarboxylate transporter 1, Electrogenic sodium monocarboxylate cotransporter, Solute carrier family 5 member 8)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Mouse

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Mouse

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

66,578 Da

Chromosome Location

Chromosome: 12; NC_000012.11 (101549994..101604016, complement). Location: 12q23.1

OMIM

608044

3D Structure

ModBase 3D Structure for Q8N695

Immunogen

Mouse Slc5a8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 548-574 amino acids from the C-terminal region of mouse Slc5a8.

Product Categories/Family for anti-SLC5A8 antibody

Antibodies; Abs to Monocarboxylate Transporter

Applications Tested/Suitable for anti-SLC5A8 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-SLC5A8 antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-SLC5A8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SLC5A8 purchase

MBS641819 is an antibody targeting SLC5A8. Also known as Slc5a8, CT (Slc5a8, Smct, Smct1, Sodium-coupled monocarboxylate transporter 1, Electrogenic sodium monocarboxylate cotransporter, Solute carrier family 5 member 8). Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC5A8. It may not necessarily be applicable to this product.

NCBI GI #

167466278

NCBI GeneID

160728

NCBI Accession #

NP_666018.3

UniProt Primary Accession #

Q8N695

UniProt Secondary Accession #

Q2TB99; Q7Z2H9

UniProt Related Accession #

Q8N695

GenBank Nucleotide #

NM_145913.3

NCBI Official Full Name

sodium-coupled monocarboxylate transporter 1

NCBI Official Synonym Full Names

solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8

NCBI Official Symbol

SLC5A8

NCBI Official Synonym Symbols

AIT; SMCT; SMCT1

UniProt Protein Name

Sodium-coupled monocarboxylate transporter 1

UniProt Synonym Protein Names

Apical iodide transporter; Electrogenic sodium monocarboxylate cotransporter; Sodium iodide-related cotransporter; Solute carrier family 5 member 8

Protein Family

Sodium-coupled monocarboxylate transporter

UniProt Gene Name

SLC5A8

UniProt Synonym Gene Names

AIT; SMCT; SMCT1

UniProt Entry Name

SC5A8_HUMAN

NCBI Protein Information

sodium-coupled monocarboxylate transporter 1; apical iodide transporter; solute carrier family 5 member 8; sodium iodide-related cotransporter; electrogenic sodium monocarboxylate cotransporter; solute carrier family 5 (iodide transporter), member 8

NCBI Summary for SLC5A8

SLC5A8 has been shown to transport iodide by a passive mechanism (Rodriguez et al., 2002 [PubMed 12107270]) and monocarboxylates and short-chain fatty acids by a sodium-coupled mechanism (Gopal et al., 2004 [PubMed 15322102]). In kidney, SLC5A8 functions as a high-affinity sodium-coupled lactate transporter involved in reabsorption of lactate and maintenance of blood lactate levels (Thangaraju et al., 2006 [PubMed 16873376]).[supplied by OMIM, Dec 2008]

UniProt Comments for SLC5A8

SLC5A8: Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D- hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D- lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.

Protein type: Apoptosis; Transporter, SLC family; Tumor suppressor; Membrane protein, multi-pass; Membrane protein, integral; Transporter

Chromosomal Location of Human Ortholog: 12q23.1

Cellular Component: apical plasma membrane; integral to membrane; plasma membrane

Molecular Function: symporter activity

Biological Process: apoptosis; sodium ion transport; ion transport; transmembrane transport

Research Articles on SLC5A8

1. These results suggest that DNA methylation in the SLC5A8 promoter region may suppress the expression of SLC5A8 in lung tumor.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SLC5A8 antibody

Reference Product	PubMed Publications
SLC22A12 antibody	>4 publications with SLC5A8 and SLC22A12
SLC5A5 antibody	>1 publications with SLC5A8 and SLC5A5

Pathways associated with anti-SLC5A8 antibody

Products by Pathway	Pathway Diagram
Organic Anion Transporters Pathway antibodies	Organic Anion Transporters Pathway Diagram
SLC-mediated Transmembrane Transport Pathway antibodies	SLC-mediated Transmembrane Transport Pathway Diagram
Transmembrane Transport Of Small Molecules Pathway antibodies	Transmembrane Transport Of Small Molecules Pathway Diagram
Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway antibodies	Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway Diagram

Diseases associated with anti-SLC5A8 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>37 publications with SLC5A8 and Neoplasms
Colonic Neoplasms Antibodies	>11 publications with SLC5A8 and Colonic Neoplasms
Thyroid Neoplasms Antibodies	>9 publications with SLC5A8 and Thyroid Neoplasms
Disease Models, Animal Antibodies	>4 publications with SLC5A8 and Disease Models, Animal
Adenocarcinoma Antibodies	>3 publications with SLC5A8 and Adenocarcinoma
Brain Diseases Antibodies	>2 publications with SLC5A8 and Brain Diseases
Fatty Liver Antibodies	>2 publications with SLC5A8 and Fatty Liver
Necrosis Antibodies	>2 publications with SLC5A8 and Necrosis
Hyperuricemia Antibodies	>2 publications with SLC5A8 and Hyperuricemia
Respiratory Tract Diseases Antibodies	>1 publications with SLC5A8 and Respiratory Tract Diseases

Organs/Tissues associated with anti-SLC5A8 antibody

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>20 publications with SLC5A8 and Kidney
Thyroid Antibodies	>16 publications with SLC5A8 and Thyroid
Eye Antibodies	>9 publications with SLC5A8 and Eye
Brain Antibodies	>6 publications with SLC5A8 and Brain
Prostate Antibodies	>3 publications with SLC5A8 and Prostate
Lung Antibodies	>2 publications with SLC5A8 and Lung
Connective Tissue Antibodies	>1 publications with SLC5A8 and Connective Tissue