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CLEC14A Antibody – Mouse Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS641848

CLEC14A (C-type lectin domain family 14 member A; also EGFR5) is a 51kD (predicted) member of the C-type lectin domain family of proteins. It is a type I transmembrane protein, apparently expressed in brain and about which little is known. Mature human… More details

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Product Overview

Online Datasheet in PDF
Product Name
CLEC14A, Polyclonal Antibody
Full Product Name
CLEC14A (C-type Lectin Domain Family 14 Member A, Epidermal Growth Factor Receptor 5, EGFR-5, C14orf27, EGFR5, UNQ236/PRO269)
Product Gene Name
anti-CLEC14A antibody
Product Synonym Names
Anti -CLEC14A (C-type Lectin Domain Family 14 Member A, Epidermal Growth Factor Receptor 5, EGFR-5, C14orf27, EGFR5, UNQ236/PRO269)
Immunogen Sequence
MRPAFALCLL WQALWPGPGG GEHPTADRAG CSASGACYSL HHATMKRQAA EEACILRGGA LSTVRAGAEL RAVLALLRAG PGPGGGSKDL LFWVALERRR SHCTLENEPL RGFSWLSSDP GGLESDTLQW VEEPQRSCTA RRCAVLQATG GVEPAGWKEM RCHLRANGYL CKYQFEVLCP APRPGAASNL SYRAPFQLHS AALDFSPPGT EVSALCRGQL PISVTCIADE IGARWDKLSG DVLCPCPGRY LRAGKCAELP NCLDDLGGFA CECATGFELG KDGRSCVTSG EGQPTLGGTG VPTRRPPATA TSPVPQRTWP IRVDEKLGET PLVPEQDNSV TSIPEIPRWG SQSTMSTLQM SLQAESKATI TPSGSVISKF NSTTSSATPQ AFDSSSAVVF IFVSTAVVVL VILTMTVLGL VKLCFHESPS SQPRKESMGP PGLESDPEPA ALGSSSAHCT NNGVKVGDCD LRDRAEGALL AESPLGSSDA
Clonality
Polyclonal
Isotype
IgG
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human CLEC14A.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
51,636 Da
Chromosome Location
Chromosome: 14; NC_000014.8 (38723205..38725575, complement). Location: 14q21.1
3D Structure
ModBase 3D Structure for Q86T13
Immunogen
Full length human CLEC14A, aa1-490 (NP_778230.1).

Product Categories/Family for anti-CLEC14A antibody

Antibodies; Abs to Lectins
Applications Tested/Suitable for anti-CLEC14A antibody
Western Blot (WB)
Application Notes for anti-CLEC14A antibody
Suitable for use in Western Blot.

Western Blot (WB) of anti-CLEC14A antibody

CLEC14A polyclonal antibody. Western Blot analysis of CLEC14A expression in human liver.
Mouse Anti-CLEC14A Polyclonal Antibody – Cat# MBS641848

Western Blot (WB) of anti-CLEC14A antibody

CLEC14A polyclonal antibody. Western Blot analysis of CLEC14A expression in HepG2.
Mouse Anti-CLEC14A Polyclonal Antibody, Western Blot (WB) – Cat# MBS641848

Western Blot (WB) of anti-CLEC14A antibody

Western Blot analysis of CLEC14A expression in transfected 293T cell line by CLEC14A polyclonal antibody. Lane 1: CLEC14A transfected lysate (53.9kD). Lane 2: Non-transfected lysate.
Mouse Anti-CLEC14A Polyclonal Antibody, Western Blot (WB) – Cat# MBS641848

Other Notes

Small volumes of anti-CLEC14A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CLEC14A purchase

MBS641848 is an antibody targeting CLEC14A. Also known as CLEC14A (C-type Lectin Domain Family 14 Member A, Epidermal Growth Factor Receptor 5, EGFR-5, C14orf27, EGFR5, UNQ236/PRO269). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CLEC14A. It may not necessarily be applicable to this product.

NCBI GI #
28269707
NCBI GeneID
161198
NCBI Accession #
NP_778230.1
UniProt Primary Accession #
Q86T13
UniProt Secondary Accession #
Q695G9; Q6PWT6; Q8N5V5
UniProt Related Accession #
Q86T13
GenBank Nucleotide #
NM_175060.2
NCBI Official Full Name
C-type lectin domain family 14 member A
NCBI Official Synonym Full Names
C-type lectin domain family 14, member A
NCBI Official Symbol
CLEC14A
NCBI Official Synonym Symbols
CEG1; EGFR-5; C14orf27
UniProt Protein Name
C-type lectin domain family 14 member A
UniProt Synonym Protein Names
Epidermal growth factor receptor 5
Protein Family
C-type lectin domain family
UniProt Gene Name
CLEC14A
UniProt Synonym Gene Names
C14orf27; EGFR5; EGFR-5
UniProt Entry Name
CLC14_HUMAN
NCBI Protein Information
C-type lectin domain family 14 member A; epidermal growth factor receptor 5; ClECT and EGF-like domain containing protein

NCBI Summary for CLEC14A

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting. [provided by RefSeq, Jan 2012]
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UniProt Comments for CLEC14A

CLEC14A:

Protein type: Membrane protein, integral; Protease

Chromosomal Location of Human Ortholog: 14q21.1

Cellular Component: integral to membrane

Molecular Function: carbohydrate binding

Research Articles on CLEC14A

1. In this study, they identify and characterize a novel tumor endothelial marker, CLEC14A, which has properties that suggest it is a candidate for tumor vascular targeting and anti-angiogenic approaches.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-CLEC14A antibody

 Disease Name  Pubmed Publications
 Carcinoma, Hepatocellular Antibodies  >1 publications with CLEC14A and Carcinoma, Hepatocellular
 Neoplasms Antibodies  >1 publications with CLEC14A and Neoplasms
 Liver Diseases Antibodies  >1 publications with CLEC14A and Liver Diseases
 Liver Neoplasms Antibodies  >1 publications with CLEC14A and Liver Neoplasms

Organs/Tissues associated with anti-CLEC14A antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >3 publications with CLEC14A and Vascular
 Blood Antibodies  >1 publications with CLEC14A and Blood
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