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STAMBP Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS641857

MBS641857 is an antibody targeting STAMBP. Also known as STAMBP (STAM-binding Protein, Associated Molecule with the SH3 Domain of STAM, AMSH, Endosome-associated Ubiquitin Isopeptidase). Reactive in Human. Host: Mouse. More details

$880 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
STAMBP, Monoclonal Antibody
Full Product Name
STAMBP (STAM-binding Protein, Associated Molecule with the SH3 Domain of STAM, AMSH, Endosome-associated Ubiquitin Isopeptidase)
Product Gene Name
anti-STAMBP antibody
Product Synonym Names
Anti -STAMBP (STAM-binding Protein, Associated Molecule with the SH3 Domain of STAM, AMSH, Endosome-associated Ubiquitin Isopeptidase)
Immunogen Sequence
MSDHGDVSLP PEDRVRALSQ LGSAVEVNED IPPRRYFRSG VEIIRMASIY SEEGNIEHAF ILYNKYITLF IEKLPKHRDY KSAVIPEKKD TVKKLKEIAF PKAEELKAEL LKRYTKEYTE YNEEKKKEAE ELARNMAIQQ ELEKEKQRVA QQKQQQLEQE QFHAFEEMIR NQELEKERLK IVQEFGKVDP GLGGPLVPDL EKPSLDVFPT LTVSSIQPSD CHTTVRPAKP PVVDRSLKPG ALSNSESIPT IDGLRHVVVP GRLCPQFLQL ASANTARGVE TCGILCGKLM RNEFTITHVL IPKQSAGSDY CNTENEEELF LIQDQQGLIT LGWIHTHPTQ TAFLSSVDLH THCSYQMMLP ESVAIVCSPK FQETGFFKLT DHGLEEISSC RQKGFHPHSK DPPLFCSCSH VTVVDRAVTI TDLR
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
1A8
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human STAMBP.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
48,077 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (74056043..74100783). Location: 2p13.1
OMIM
606247
3D Structure
ModBase 3D Structure for O95630
Immunogen
Full length recombinant corresponding to aa1-424 from STAMBP (AAH65574) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-STAMBP antibody

Antibodies; Abs to Ubiquitin
Applications Tested/Suitable for anti-STAMBP antibody
ELISA (EL/EIA), Immunofluorescence (IF)
Application Notes for anti-STAMBP antibody
Suitable for use in Immunofluorescence and ELISA.
Dilution: Immunofluorescence: 10ug/ml

Immunofluorescence (IF) of anti-STAMBP antibody

Immunofluorescence of monoclonal antibody to STAMBP on HeLa cell . [antibody concentration 10ug/ml]
Mouse Anti-STAMBP Monoclonal Antibody – Cat# MBS641857

Testing Data of anti-STAMBP antibody

Detection limit for recombinant GST tagged STAMBP is ~0.3ng/ml as a capture antibody.
Mouse Anti-STAMBP Monoclonal Antibody, Testing Data – Cat# MBS641857

Other Notes

Small volumes of anti-STAMBP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for STAMBP. It may not necessarily be applicable to this product.

NCBI GI #
47132534
NCBI GeneID
10617
NCBI Accession #
NP_998787.1
UniProt Primary Accession #
O95630
UniProt Secondary Accession #
Q3MJE7; D6W5H7
UniProt Related Accession #
O95630
GenBank Nucleotide #
NM_213622.2
NCBI Official Full Name
STAM-binding protein
NCBI Official Synonym Full Names
STAM binding protein
NCBI Official Symbol
STAMBP
NCBI Official Synonym Symbols
AMSH; MICCAP
UniProt Protein Name
STAM-binding protein
UniProt Synonym Protein Names
Associated molecule with the SH3 domain of STAM; Endosome-associated ubiquitin isopeptidase
Protein Family
STAM-binding protein
UniProt Gene Name
STAMBP
UniProt Synonym Gene Names
AMSH
UniProt Entry Name
STABP_HUMAN
NCBI Protein Information
STAM-binding protein; endosome-associated ubiquitin isopeptidase; associated molecule with the SH3 domain of STAM

NCBI Summary for STAMBP

Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for STAMBP

AMSH: an adaptor protein involved in cytokine signal transduction the JAK-STAT cascade. Binds to the SH3 domain of the signal-transducing adaptor molecule STAM (signal transducing adaptor molecule). May play a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression.

Protein type: EC 3.4.19.-; Protease; Ubiquitin-specific protease; EC 3.1.2.15

Chromosomal Location of Human Ortholog: 2p13.1

Cellular Component: nucleoplasm; early endosome; cytoplasm; plasma membrane; nucleus; cleavage furrow

Molecular Function: protein domain specific binding; protein binding; metallopeptidase activity; metal ion binding; ubiquitin-specific protease activity

Biological Process: protein deubiquitination; cytokinesis after mitosis; positive regulation of cell proliferation; negative regulation of Ras protein signal transduction; negative regulation of neuron apoptosis; proteolysis; JAK-STAT cascade; negative regulation of phosphoinositide 3-kinase cascade

Disease: Microcephaly-capillary Malformation Syndrome
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Research Articles on STAMBP

1. Mutations in STAMBP, encoding a deubiquitinating enzyme, cause microcephaly-capillary malformation syndrome.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-STAMBP antibody

 Reference Product  PubMed Publications
 STAM antibody  >17 publications with STAMBP and STAM
 EGFR antibody  >4 publications with STAMBP and EGFR
 CHMP1A antibody  >3 publications with STAMBP and CHMP1A
 GRB2 antibody  >2 publications with STAMBP and GRB2
 VPS24 antibody  >2 publications with STAMBP and VPS24
 SMURF2 antibody  >1 publications with STAMBP and SMURF2
 RNF11 antibody  >1 publications with STAMBP and RNF11
 STAM2 antibody  >1 publications with STAMBP and STAM2

Pathways associated with anti-STAMBP antibody

 Products by Pathway  Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Internalization Of ErbB1 Pathway antibodies  Internalization Of ErbB1 Pathway Diagram

Diseases associated with anti-STAMBP antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >2 publications with STAMBP and Brain Diseases
 Developmental Disabilities Antibodies  >1 publications with STAMBP and Developmental Disabilities
 Epilepsy Antibodies  >1 publications with STAMBP and Epilepsy
 Microcephaly Antibodies  >1 publications with STAMBP and Microcephaly

Organs/Tissues associated with anti-STAMBP antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with STAMBP and Brain
 Parathyroid Antibodies  >1 publications with STAMBP and Parathyroid
 Vascular Antibodies  >1 publications with STAMBP and Vascular
 Testis Antibodies  >1 publications with STAMBP and Testis
 Embryonic Tissue Antibodies  >1 publications with STAMBP and Embryonic Tissue
 Skin Antibodies  >1 publications with STAMBP and Skin
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