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CLDN12 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS641922

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. More details

$880 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CLDN12, Monoclonal Antibody
Full Product Name
CLDN12 (Claudin-12, Claudin 12)
Product Gene Name
Product Synonym Names
Anti -CLDN12 (Claudin-12, Claudin 12)
Immunogen Sequence
MGCRDVHAAT VLSFLCGIAS VAGLFAGTLL PNWRKLRLIT FNRNEKNLTV YTGLWVKCAR YDGSSDCLMY DTTWYSSVDQ LDLRVLQFAL PLSMLIAMGA LLLCLIGMCN TAFRSSVPNI KLAKCLVNSA GCHLVAGLLF FLAGTVSLSP SIWVIFYNIH LNKKFEPVFS FDYAVYVTIA SAGGLFMTSL ILFIWYCTCK SLPSPFWQPL YSHPPSMHTY SQPYSARSRL SAIEIDIPVV SHTT
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
2D8
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human CLDN12.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
27,094 Da
Chromosome Location
Chromosome: 7; NC_000007.13 (90032648..90045268). Location: 7q21
3D Structure
ModBase 3D Structure for Q6FIF6
Immunogen
Full-length recombinant corresponding to aa1-244 from CLDN12 (AAH36754) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-CLDN12 antibody

Applications Tested/Suitable for anti-CLDN12 antibody
ELISA (EL/EIA)
Application Notes for anti-CLDN12 antibody
Suitable for use in ELISA.

Testing Data of anti-CLDN12 antibody

Detection limit for recombinant GST tagged CLDN12 is 0.3 ng/ml using MBS641922.
Mouse Anti-CLDN12 Monoclonal Antibody – Cat# MBS641922

Other Notes

Small volumes of anti-CLDN12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CLDN12 purchase

MBS641922 is an antibody targeting CLDN12. Also known as CLDN12 (Claudin-12, Claudin 12). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CLDN12. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
NCBI Official Full Name
CLDN12
NCBI Official Synonym Full Names
claudin 12
NCBI Official Symbol
CLDN12
UniProt Protein Name
Claudin
Protein Family
UniProt Gene Name
CLDN12
UniProt Entry Name
Q6FIF6_HUMAN
NCBI Protein Information
claudin-12

NCBI Summary for CLDN12

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in the inner ear and bladder epithelium, and it is over-expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, Sep 2011]
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UniProt Comments for CLDN12

Claudin-12: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Belongs to the claudin family.

Protein type: Membrane protein, multi-pass; Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q21

Cellular Component: tight junction; integral to membrane; lateral plasma membrane

Molecular Function: identical protein binding; structural molecule activity

Biological Process: intercellular junction assembly and maintenance; calcium-independent cell-cell adhesion
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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