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FSTL3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS641948

Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. More details

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Product Overview

Online Datasheet in PDF
Product Name
FSTL3, Polyclonal Antibody
Full Product Name
FSTL3, CT (FSTL3, FLRG, Follistatin-related protein 3, Follistatin-like protein 3, Follistatin-related gene protein)
Product Gene Name
anti-FSTL3 antibody
Product Synonym Names
Anti -FSTL3, CT (FSTL3, FLRG, Follistatin-related protein 3, Follistatin-like protein 3, Follistatin-related gene protein)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
27,663 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (676389..683392). Location: 19p13
OMIM
605343
3D Structure
ModBase 3D Structure for O95633
Immunogen
FSTL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 228-258 amino acids from the C-terminal region of human FSTL3.

Product Categories/Family for anti-FSTL3 antibody

Antibodies; Abs to Proteins
Applications Tested/Suitable for anti-FSTL3 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-FSTL3 antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Western Blot (WB) of anti-FSTL3 antibody

Western Blot analysis in CEM cell line lysates, using MBS641948 (35ug/lane). This demonstrates that MBS641948 detected the FSTL3 protein (arrow).
Rabbit Anti-FSTL3 Polyclonal Antibody – Cat# MBS641948

Western Blot (WB) of anti-FSTL3 antibody

Western Blot analysis in HepG2 whole cell lysate (20ug) using MBS641948 (1:2000). Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10,000. Predicted band size: 28kD. Blocking/Dilution buffer: 5% NFDM/TBST.
Rabbit Anti-FSTL3 Polyclonal Antibody, Western Blot (WB) – Cat# MBS641948

Western Blot (WB) of anti-FSTL3 antibody

Western Blot analysis in A431 whole cell lysate (20ug) using MBS641948 (1:1000). Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10,000. Predicted band size: 28kD. Blocking/Dilution buffer: 5% NFDM/TBST.
Rabbit Anti-FSTL3 Polyclonal Antibody, Western Blot (WB) – Cat# MBS641948

Immunohistochemistry (IHC) of anti-FSTL3 antibody

Immunohistochemistry staining FSTL3 in human testis tissue sectionsusing MBS641948. Tissue was fixed with formaldehyde and blocked with 3% BSA for 0.5 hrs at RT; antigen retrieval was by heat mediation with a citrate buffer (pH 6). Samples were incubated with MBS641948 (1:25) for 1 hr at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody.
Rabbit Anti-FSTL3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS641948

Other Notes

Small volumes of anti-FSTL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FSTL3 purchase

MBS641948 is an antibody targeting FSTL3. Also known as FSTL3, CT (FSTL3, FLRG, Follistatin-related protein 3, Follistatin-like protein 3, Follistatin-related gene protein). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FSTL3. It may not necessarily be applicable to this product.

NCBI GI #
5031701
NCBI GeneID
10272
NCBI Accession #
NP_005851.1
UniProt Primary Accession #
O95633
UniProt Secondary Accession #
A8K7E3
UniProt Related Accession #
O95633
GenBank Nucleotide #
NM_005860.2
NCBI Official Full Name
follistatin-related protein 3
NCBI Official Synonym Full Names
follistatin-like 3 (secreted glycoprotein)
NCBI Official Symbol
FSTL3
NCBI Official Synonym Symbols
FLRG; FSRP
UniProt Protein Name
Follistatin-related protein 3
UniProt Synonym Protein Names
Follistatin-like protein 3; Follistatin-related gene protein
Protein Family
Follistatin-related protein
UniProt Gene Name
FSTL3
UniProt Synonym Gene Names
FLRG
UniProt Entry Name
FSTL3_HUMAN
NCBI Protein Information
follistatin-related protein 3; follistatin-like protein 3; follistatin-related gene protein

UniProt Comments for FSTL3

FSTL3: Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10. A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1. 2 isoforms of the human protein are produced by alternative initiation.

Protein type: Secreted, signal peptide; Secreted; Oncoprotein

Chromosomal Location of Human Ortholog: 19p13

Cellular Component: nucleoplasm; Golgi apparatus; extracellular space; extracellular region; nucleus; secretory granule

Molecular Function: protein binding; fibronectin binding; activin binding

Biological Process: negative regulation of osteoclast differentiation; ossification; transcription, DNA-dependent; adrenal gland development; male gonad development; negative regulation of BMP signaling pathway; regulation of transcription from RNA polymerase II promoter; negative regulation of activin receptor signaling pathway; positive regulation of cell-cell adhesion; spermatogenesis; positive regulation of transcription from RNA polymerase II promoter; hemopoietic progenitor cell differentiation; kidney development; lung development
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Research Articles on FSTL3

1. Resistance exercise resulted in a significant downregulation of MSTN and FBXO32 mRNA expression and a significant upregulation in FSTL3 and SMURF1 mRNA expression, and carbohydrate and protein feeding have little influence on the these markers expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FSTL3 antibody

 Reference Product  PubMed Publications
 MSTN antibody  >21 publications with FSTL3 and MSTN
 INHBA antibody  >3 publications with FSTL3 and INHBA
 FN1 antibody  >1 publications with FSTL3 and FN1
 ADAM12 antibody  >1 publications with FSTL3 and ADAM12
 SMAD4 antibody  >1 publications with FSTL3 and SMAD4

Pathways associated with anti-FSTL3 antibody

 Products by Pathway  Pathway Diagram
 Antagonism Of Activin By Follistatin Pathway antibodies  Antagonism Of Activin By Follistatin Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Activin Pathway antibodies  Signaling By Activin Pathway Diagram

Diseases associated with anti-FSTL3 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >24 publications with FSTL3 and Neoplasms
 Musculoskeletal Diseases Antibodies  >20 publications with FSTL3 and Musculoskeletal Diseases
 Nervous System Diseases Antibodies  >17 publications with FSTL3 and Nervous System Diseases
 Inflammation Antibodies  >13 publications with FSTL3 and Inflammation
 Carcinoma Antibodies  >11 publications with FSTL3 and Carcinoma
 Hypertrophy Antibodies  >8 publications with FSTL3 and Hypertrophy
 Brain Diseases Antibodies  >7 publications with FSTL3 and Brain Diseases
 Hyperplasia Antibodies  >6 publications with FSTL3 and Hyperplasia
 Fibrosis Antibodies  >6 publications with FSTL3 and Fibrosis
 Liver Diseases Antibodies  >5 publications with FSTL3 and Liver Diseases

Organs/Tissues associated with anti-FSTL3 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >46 publications with FSTL3 and Muscle
 Bone Antibodies  >37 publications with FSTL3 and Bone
 Blood Antibodies  >35 publications with FSTL3 and Blood
 Heart Antibodies  >27 publications with FSTL3 and Heart
 Embryonic Tissue Antibodies  >25 publications with FSTL3 and Embryonic Tissue
 Brain Antibodies  >23 publications with FSTL3 and Brain
 Placenta Antibodies  >16 publications with FSTL3 and Placenta
 Lung Antibodies  >14 publications with FSTL3 and Lung
 Ovary Antibodies  >12 publications with FSTL3 and Ovary
 Testis Antibodies  >10 publications with FSTL3 and Testis
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