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TICAM2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS641994

TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030). More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TICAM2, Polyclonal Antibody
Full Product Name
TICAM2, NT (TICAM2, TIRAP3, TIRP, TRAM, TIR domain-containing adapter molecule 2, Putative NF-kappa-B-activating protein 502, TRIF-related adapter molecule, Toll-like receptor adaptor protein 3, Toll/interleukin-1 receptor domain-containing protein)
Product Gene Name
anti-TICAM2 antibody
Product Synonym Names
Anti -TICAM2, NT (TICAM2, TIRAP3, TIRP, TRAM, TIR domain-containing adapter molecule 2, Putative NF-kappa-B-activating protein 502, TRIF-related adapter molecule, Toll-like receptor adaptor protein 3, Toll/interleukin-1 receptor domain-containing protein)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
26,916 Da
Chromosome Location
Chromosome: 5; NC_000005.9 (114914339..114952142, complement). Location: 5q23.1
OMIM
608321
3D Structure
ModBase 3D Structure for Q86XR7
Immunogen
TICAM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-41 amino acids from the N-terminal region of human TICAM2.

Product Categories/Family for anti-TICAM2 antibody

Antibodies; Abs to Interleukin
Applications Tested/Suitable for anti-TICAM2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-TICAM2 antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Western Blot (WB) of anti-TICAM2 antibody

TICAM2 Antibody (N-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the TICAM2 antibody detected the TICAM2 protein (arrow).
Rabbit Anti-TICAM2 Polyclonal Antibody – Cat# MBS641994

Other Notes

Small volumes of anti-TICAM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TICAM2 purchase

MBS641994 is an antibody targeting TICAM2. Also known as TICAM2, NT (TICAM2, TIRAP3, TIRP, TRAM, TIR domain-containing adapter molecule 2, Putative NF-kappa-B-activating protein 502, TRIF-related adapter molecule, Toll-like receptor adaptor protein 3, Toll/interleukin-1 receptor domain-containing protein). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TICAM2. It may not necessarily be applicable to this product.

NCBI GI #
80479074
NCBI GeneID
353376
NCBI Accession #
AAI09266.1
UniProt Primary Accession #
Q86XR7
UniProt Secondary Accession #
Q6JUT2; B3Y698
UniProt Related Accession #
Q86XR7
NCBI Official Full Name
TICAM2 protein
NCBI Official Synonym Full Names
toll-like receptor adaptor molecule 2
NCBI Official Symbol
TICAM2
NCBI Official Synonym Symbols
TIRP; TRAM; TIRAP3; MyD88-4; TICAM-2
UniProt Protein Name
TIR domain-containing adapter molecule 2
UniProt Synonym Protein Names
Putative NF-kappa-B-activating protein 502; TRIF-related adapter molecule; Toll-like receptor adaptor protein 3; Toll/interleukin-1 receptor domain-containing protein
Protein Family
TIR domain-containing adapter molecule
UniProt Gene Name
TICAM2
UniProt Synonym Gene Names
TIRAP3; TIRP; TRAM; TICAM-2; MyD88-4
UniProt Entry Name
TCAM2_HUMAN
NCBI Protein Information
TIR domain-containing adapter molecule 2; cytoplasmic adaptor; TRIF-related adaptor molecule; NF-kappa-B-activating protein 502; toll-like receptor adaptor protein 3; putative NF-kappa-B-activating protein 502; toll/interleukin-1 receptor (TIR) domain-containing adapter protein

UniProt Comments for TICAM2

TICAM2: a toll-like receptor adapter that participates in induction of type 1 interferons. Transiently phosphorylated on serine-16 during LPS/Toll-like receptor 4 (TLR4) signaling. Activated TLR4 associates with four adapter proteins, MyD88, TIRAP, TICAM-1 (Trif), and TICAM-2.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 5q23.1

Cellular Component: Golgi apparatus; late endosome membrane; endoplasmic reticulum; early endosome membrane; late endosome; early endosome; plasma membrane; endosome membrane

Molecular Function: signal transducer activity; phospholipid binding

Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of interferon-gamma production; positive regulation of I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; negative regulation of toll-like receptor 4 signaling pathway; toll-like receptor signaling pathway; positive regulation of toll-like receptor 4 signaling pathway; positive regulation of interleukin-6 production; innate immune response; toll-like receptor 3 signaling pathway; inflammatory response; toll-like receptor 4 signaling pathway
Show more

Research Articles on TICAM2

1. induction of both IL-6 and IL-8 is associated with elevated TIRAP and reduced TRAM mRNA expression

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TICAM2 antibody

 Reference Product  PubMed Publications
 TLR4 antibody  >19 publications with TICAM2 and TLR4
 TICAM1 antibody  >18 publications with TICAM2 and TICAM1
 TIRAP antibody  >15 publications with TICAM2 and TIRAP
 TLR3 antibody  >6 publications with TICAM2 and TLR3
 TRAF6 antibody  >6 publications with TICAM2 and TRAF6
 IRF3 antibody  >5 publications with TICAM2 and IRF3
 LY96 antibody  >2 publications with TICAM2 and LY96
 IRAK1 antibody  >2 publications with TICAM2 and IRAK1
 IRAK4 antibody  >1 publications with TICAM2 and IRAK4
 IL1R1 antibody  >1 publications with TICAM2 and IL1R1

Pathways associated with anti-TICAM2 antibody

 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway antibodies  Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway Diagram
 Hepatitis B Pathway antibodies  Hepatitis B Pathway Diagram
 IKK Complex Recruitment Mediated By RIP1 Pathway antibodies  IKK Complex Recruitment Mediated By RIP1 Pathway Diagram
 IL1-mediated Signaling Events Pathway antibodies  IL1-mediated Signaling Events Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 MyD88-independent Cascade Pathway antibodies  MyD88-independent Cascade Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram

Organs/Tissues associated with anti-TICAM2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with TICAM2 and Blood
 Liver Antibodies  >2 publications with TICAM2 and Liver
 Brain Antibodies  >2 publications with TICAM2 and Brain
 Spleen Antibodies  >1 publications with TICAM2 and Spleen
 Thymus Antibodies  >1 publications with TICAM2 and Thymus
 Kidney Antibodies  >1 publications with TICAM2 and Kidney
 Intestine Antibodies  >1 publications with TICAM2 and Intestine
 Embryonic Tissue Antibodies  >1 publications with TICAM2 and Embryonic Tissue
 Uterus Antibodies  >1 publications with TICAM2 and Uterus
 Placenta Antibodies  >1 publications with TICAM2 and Placenta
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